Results 51 to 60 of about 46,167 (292)

The history and evolution of HLA typing external proficiency testing schemes in UK NEQAS for H&I

Frontiers in Genetics, 2023
The UK National External Quality Assessment Service (NEQAS) provide an external proficiency testing (EPT) service for clinical laboratories. UK NEQAS for Histocompatibility and Immunogenetics (H&I) has been providing EPT schemes for over 45 years and
A. De’Ath, M. T. Rees, D. Pritchard
doaj   +1 more source

Histocompatibility testing in patients with carcinoma of the bladder [PDF]

Cancer, 1983
A number of disease states have been found to have a positive association with certain HLA antigens. Weak associations have been described for a number of cancers. Seventy patients with transitional cell carcinoma of the bladder underwent serotyping for HLA, A, B, C, and DR antigens. There were 54 men and 16 women patients with a mean age of 65.3 years.
B, Lytton, C, O'Toole, R, Tiptaft, H, Festenstein, J R, Batchelor   +4 more
openaire   +2 more sources

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Combination Testing Using a Single MSH5 Variant alongside HLA Haplotypes Improves the Sensitivity of Predicting Coeliac Disease Risk in the Polish Population. [PDF]

PLoS ONE, 2015
Assessment of non-HLA variants alongside standard HLA testing was previously shown to improve the identification of potential coeliac disease (CD) patients.
Agnieszka Paziewska, Bozena Cukrowska, Michalina Dabrowska, Krzysztof Goryca, Magdalena Piatkowska, Anna Kluska, Michal Mikula, Jakub Karczmarski, Beata Oralewska, Anna Rybak, Jerzy Socha, Aneta Balabas, Natalia Zeber-Lubecka, Filip Ambrozkiewicz, Ewa Konopka, Ilona Trojanowska, Malgorzata Zagroba, Malgorzata Szperl, Jerzy Ostrowski   +18 more
doaj   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Tipificación molecular de los antígenos leucocitarios humanos, Estado del arte y perspectivas para los transplantes de células madre en Costa Rica Molecular typing of Human Leukocyte Antigens, State-of-theart and Perspectives for Stem cell Transplantation in Costa Rica

Acta Médica Costarricense, 2010
El sistema de antígenos leucocitarios (Human Leukocyte Antigen) es el más polimórfico en el ser humano. Su función la realiza regulando la respuesta inmune mediante su unión a moléculas como el receptor de células T, participando en la presentación de ...
Esteban Arrieta-Bolaños, Lizbeth Salazar-Sánchez   +1 more
doaj  

Application of flow cytometry in transfusion medicine

Global Journal of Transfusion Medicine, 2019
Flow cytometry-based testing approaches have no longer remained restricted to the research laboratories. With widening of its horizons in the field of diagnostics in oncology and transplantation medicine, the flow cytometer-based testing approach is now ...
Rajesh B Sawant
doaj   +1 more source

Cell Squeeze: driving more effective CD8 T-cell activation through cytosolic antigen delivery

Immuno-Oncology and Technology, 2022
Cell Squeeze is a novel technology that relies on temporarily disrupting the cell membrane to deliver cargo directly into the cytosol. This approach is applicable to a broad range of cell types (peripheral blood mononuclear cells, red blood cells ...
J.C. Park, H. Bernstein, S. Loughhead, R. Zwirtes, J. Jennings, V. Nicolini, C. Klein, L.C. Deak, P. Umana, C. Trumpfheller, A. Sharei   +10 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source