Results 41 to 50 of about 46,167 (292)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Prozone phenomenon in pretransplant testing: An interesting conundrum involving solid-phase and cell-based assays

Asian Journal of Transfusion Science, 2022
BACKGROUND: Human leukocyte antigen (HLA) is a major determinant in deciding upon solid organ histocompatibility. Donor-specific anti-HLA antibodies (Donor-specific anti-HLA antibodies (DSAs)) are always a contraindication for solid organ transplantation,
Parvind Singh, Aseem Kumar Tiwari, Vikash Chandra Mishra, Trupti Vimlakar Deshpande, Pranav Dorwal, Amit Kr Bhardwaj, Sneha Kumari, Vimarsh Raina   +7 more
doaj   +1 more source

Definitions of histocompatibility typing terms

, 2011
Histocompatibility testing for stem cell and solid organ transplantation has become increasingly complex as newly discovered HLA alleles are described.
Wagenknecht, Dawn R, Cynthia Taves, Carolyn Katovich Hurley, Fernandez-Vina, Marcelo, Heslop, Helen, Noreen, Harriet, Helen Heslop, Marcelo Fernandez-Vina, Eduardo Nunes, Dawn R. Wagenknecht, Sacchi, Nicoletta, Eisenbrey, A Bradley, Harriet Noreen, Kay Poulton, Nunes, Eduardo, Gottfried Fischer, Nicoletta Sacchi, Taves, Cynthia, Fischer, Gottfried, Hurley, Carolyn Katovich, Wacker, Kara, Kara Wacker, Poulton, Kay, A. Bradley Eisenbrey   +23 more
core   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Mechanism of remodeling and local effects in vivo of a new injectable cosmetic filler

Scientific Reports, 2023
By studying the local effects of a new type of injectable cosmetic filler implanted into the animal to explore the mechanism of remodeling and cosmetic effect of this kind of product.
Likui Sun, Xiaoxia Sun, Wenting Ruan, Guoxi Che, Fuyu Zhu, Chenghu Liu, Min Wan   +6 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

An Interesting Case of Renal Transplantation: Resolving Discrepancies in Histocompatibility Testing

Indian Journal of Transplantation
Histocompatibility testing plays an important role in the success of renal transplantation outcome by ensuring optimal donor recipient compatibility. Developments in testing methods have increased transplant success, but discrepancies between different ...
Vikash Chandra Mishra, Dinesh Chandra, Ritu Sharma, Vimarsh Raina   +3 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Intermediate steroid withdrawal after renal transplantation and anti-HLA antibodies (HLA-Abs) development

Nefrología (English Edition), 2017
Introduction: Steroid withdrawal in renal transplantation is desirable to avoid their adverse effects. However, by decreasing the immunosuppression, could lead to an increased risk for the development of HLA-Abs.
Elena Monfá, David San Segundo, Juan Carlos Ruiz San Millán, Judith Sanabria, Zoila Albines, Emilio Rodrigo, Iñigo Romón, Esther Asensio, Manuel Arias, Marcos López-Hoyos   +9 more
doaj   +3 more sources

Proficiency testing within Eurotransplant

Frontiers in Genetics
Eurotransplant is responsible for the international allocation of organs between eight countries in Europe. All HLA laboratories affiliated to Eurotransplant must be EFI or ASHI-accredited and must participate in the Eurotransplant external proficiency ...
Yvonne M. Zoet, Sebastiaan Heidt, Marissa J. H. van der Linden-van Oevelen, Geert W. Haasnoot, Frans H. J. Claas   +4 more
doaj   +1 more source