Results 71 to 80 of about 976,058 (304)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Monte Carlo Integration with Subtraction

, 2012
This paper investigates a class of algorithms for numerical integration of a function in d dimensions over a compact domain by Monte Carlo methods. We construct a histogram approximation to the function using a partition of the integration domain into a ...
Arthur, Rudy, Kennedy, A. D.
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

A Convex Model for Edge-Histogram Specification with Applications to Edge-preserving Smoothing

, 2018
The goal of edge-histogram specification is to find an image whose edge image has a histogram that matches a given edge-histogram as much as possible. Mignotte has proposed a non-convex model for the problem [M. Mignotte.
Chan, Kelvin C. K., Chan, Raymond H., Nikolova, Mila   +2 more
core   +1 more source

Morphological geodesic active contour algorithm for the segmentation of the histogram‐equalized welding bead image edges [PDF]

, 2022
John Mlyahilu, Nunna Joseph Mlyahilu, Jae Eun Lee, Young Bong Kim, Jong Nam Kim   +4 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Identification of the Structure of Liquid–Gas Flow in a Horizontal Pipeline Using the Gamma-Ray Absorption and a Convolutional Neural Network

Applied Sciences
Knowledge of the liquid–gas flow regime is important for the proper control of many industrial processes (e.g., in the mining, nuclear, petrochemical, and environmental industries).
Robert Hanus, Marcin Zych, Piotr Ochał, Małgorzata Augustyn   +3 more
doaj   +1 more source

Renkli Görüntüler İçin Tek Boyutlu Histogram

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2018
Histogramsayısal görüntülerdeki piksellerin dağılımını gösteren önemli bir bilgi temsilyöntemidir. Gri seviyeli görüntülerde tek boyutlu dizi işlenirken, renkligörüntülerde üç boyutlu dizinin analizinin yapılması gereklidir.
Mahmut Kılıçaslan, Ufuk Tanyeri, Recep Demirci   +2 more
doaj   +1 more source

Better than counting: Density profiles from force sampling

, 2018
Calculating one-body density profiles in equilibrium via particle-based simulation methods involves counting of events of particle occurrences at (histogram-resolved) space points.
Heras, Daniel de las, Schmidt, Matthias
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source