Results 91 to 100 of about 207,989 (291)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Ameliorating Effects of Vitamin E on Morphological and Histological Alterations and Oxidative Stress Factors Assessment Against Titanium Dioxide Nanoparticle-Induced in Mice Testis [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objectives: Nano titanium dioxide particles (TiO2) are chemical compounds that are widely used in industrial and foodstuff such as cosmetics, toothpaste, colored materials, and non-fat milk whitening.
ramin jahangirfard, ahmad reza raji, Amir moghaddam jafari, Hossein Nourani   +3 more
doaj  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Growth, age and size of the Jurassic pachycormid Leedsichthys problematicus (Osteichthyes: Actinopterygii) [PDF]

, 2013
The Jurassic pachycormid osteichthyan Leedsichthys problematicus is renowned for having been able to achieve prodigious size for a bony fish. Building on work of MARTILL (1986a), a thorough examination of all known material was conducted in order to ...
Adams, C., Challands, T., Liston, J., Newbrey, M.   +3 more
core  

Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND) [PDF]

, 2018
A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology.
Ball, G, Edwards, A D, Jones, M, So, P-W, Stolp, H B, Thornton, C, Tournier, J-D   +6 more
core   +6 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Clinical parameters, histological analysis, and laser Doppler flowmetry of different subepithelial connective tissue grafts

Journal of Indian Society of Periodontology, 2018
Subepithelial connective tissue graft (SCTG) presents favorable outcomes. However, the harvesting technique can influence the anatomical and histological composition of the SCTG.
Ricardo Rabelo Eustachio, Rafael Ferreira, Nair Cristina Margarida Brondino, Carla Andreotti Damante, Maria Lucia Rubo De Rezende, Adriana Campos Passanezi Sant'ana, Sebastião Luiz Aguiar Greghi, Mariana Schutzer Ragghianti Zangrando   +7 more
doaj   +1 more source

Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age [PDF]

, 2018
Cortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply.
A Goring, AA Pitsillides, B Javaheri, CE Clarkin, D Gomez-Nicola, E Hesse, H Razi, JA Núñez, null null, P Schneider, PJ Thurner   +10 more
core   +5 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis

Scientific Reports
Detecting breast tissue alterations is essential for cancer diagnosis. However, inherent bidimensionality limits histological procedures’ effectiveness in identifying these changes.
Sandro Donato, Lucia Mariel Arana Peña, Fulvia Arfelli, Luca Brombal, Luisella Colmo, Renata Longo, Fulvia Martellani, Giuliana Tromba, Fabrizio Zanconati, Deborah Bonazza   +9 more
doaj   +1 more source