Results 41 to 50 of about 1,657,839 (363)

Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy

Nature Biomedical Engineering, 2017
Conventional methods for intraoperative histopathologic diagnosis are labour- and time-intensive, and may delay decision-making during brain-tumour surgery.
D. Orringer, B. Pandian, Y. Niknafs, Todd C. Hollon, J. Boyle, Spencer Lewis, Mia Garrard, S. Hervey-Jumper, H. Garton, C. Maher, J. Heth, O. Sagher, D. Wilkinson, M. Snuderl, S. Venneti, S. Ramkissoon, K. McFadden, Amanda O. Fisher-Hubbard, A. Lieberman, T. Johnson, X. Xie, J. Trautman, C. Freudiger, S. Camelo-Piragua   +23 more
semanticscholar   +1 more source

Atrial Lesions in a Pedigree With PRKAG2 Cardiomyopathy: Involvement of Disrupted AMP-Activated Protein Kinase Signaling

Frontiers in Cardiovascular Medicine, 2022
PRKAG2 cardiomyopathy is a rare progressive disease characterized by increased ventricular wall thickness and preexcitation. Dysfunction of the protein 5′-AMP-activated protein kinase (AMPK) plays a decisive role in the progression of ventricular lesions.
Shaojie Chen, Yongping Lin, Yue Zhu, Le Geng, Chang Cui, Zhaomin Li, Hailei Liu, Hongwu Chen, Weizhu Ju, Minglong Chen   +9 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Deep weakly-supervised learning methods for classification and localization in histology images: a survey [PDF]

Machine Learning for Biomedical Imaging, 2019
Using state-of-the-art deep learning (DL) models to diagnose cancer from histology data presents several challenges related to the nature and availability of labeled histology images, including image size, stain variations, and label ambiguity.
Jérôme Rony, Soufiane Belharbi, J. Dolz, Ismail Ben Ayed, Luke McCaffrey, Eric Granger   +5 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Multi-class texture analysis in colorectal cancer histology

Scientific Reports, 2016
Automatic recognition of different tissue types in histological images is an essential part in the digital pathology toolbox. Texture analysis is commonly used to address this problem; mainly in the context of estimating the tumour/stroma ratio on ...
Jakob Nikolas Kather, Cleo-Aron Weis, F. Bianconi, Susanne Melchers, L. Schad, T. Gaiser, A. Marx, F. Zöllner   +7 more
semanticscholar   +1 more source

Antihyperglycemic and histological effects on the pancreas of the aqueous leaves extract of Annona squamosa L. in normal and diabetic rats [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2009
The purposes of our present study were to investigate the antihyperglycemic effect of aqueous leaves extract ofAnnona squamosa L. at different doses and histology of the pancreas in normal and diabetic rats after receiving the extract.
Pornrut Rabintossaporn, Suphaket Saenthaweesuk, Amornnat Thuppia, Seewaboon Sireeratawong, Kornkanok Ingkaninan   +4 more
doaj  

The Essentials of Histology [PDF]

Nature, 1885
THIS will prove a useful book for students. It is arranged in forty-two lessons and appendix. Each lesson commences with a short statement of methods for the microscopic examination of the tissue described in the lesson. All simple tissues and organs are thus passed in review, and their most essential characters are succinctly described and illustrated.
openaire   +2 more sources

Brain histology

Practical Neurology, 2008
In this article we summarise nervous system histology in health and disease and acquaint the reader with developments in the staining techniques that are in current use, particularly immunostains. Although clinicians do not need to know the details of stain appearances, some familiarity with these aspects of neuropathology is invaluable in interpreting
Jeans, A, Esiri, M
openaire   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source