Results 171 to 180 of about 476,173 (298)

H2B.W2, a Spermatocytes-specific Histone Variant, disrupts nucleosome stability and reduces chromatin compaction [PDF]

Thi Thuy Nguyen, Dongbo Ding, Xingpeng Bai, Matthew Yu Hin Pang, Mingxi Deng, Yue Liu, Ting Jin, Xu Zhichun, Yingyi Zhang, Yuanliang Zhai, Yan Yan, Toyotaka Ishibashi   +11 more
openalex   +1 more source

Decision letter: Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

, 2020
Amber L. Southwell
openalex   +1 more source

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Histone Lactylation Participates in Psoriasis Progression by Regulating the Adiponectin Expression

Clinical, Cosmetic and Investigational Dermatology
Sicheng Zhao, Tingyan Wu, Mingjing Fu, Zhe Zhang Department of Dermatology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, People’s Republic of ChinaCorrespondence: Sicheng Zhao, Department of Dermatology, Suzhou ...
Zhao S, Wu T, Fu M, Zhang Z
doaj  

Histone lactylation modification and its role in cerebral ischemia-reperfusion injury (Review). [PDF]

Biomed Rep
Tao J, Xu J, Zhou L.
europepmc   +1 more source

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis [PDF]

, 2018
William B. Tu, Yu-Jia Shiah, Corey Lourenco, Peter J. Mullen, Dharmendra Dingar, Cornelia Redel, Aaliya Tamachi, Wail Ba-Alawi, Asma M. Aman, Rima Al‐awar, David W. Cescon, Benjamin Haibe‐Kains, C.H. Arrowsmith, Brian Raught, Paul C. Boutros, Linda Z. Penn   +15 more
openalex   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Lack of preclinical support for the efficacy of histone deacetylase inhibitors in the treatment of psoriasis

, 2015
Anna‐Karin Ekman, Charlotta Enerbäck
openalex   +2 more sources

Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition [PDF]

, 2013
José P. López‐Atalaya, Satomi Ito, Luis M. Valor, Eva Benito, Ángel Barco   +4 more
openalex   +1 more source