Results 211 to 220 of about 753,787 (333)

SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

Advanced Science, EarlyView.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian   +13 more
wiley   +1 more source

A histone acetylation-based predictive model for immunotherapy response and combinatorial targeting in cervical cancer. [PDF]

Medicine (Baltimore)
Zhang X, Li M, Wang K, Sun Z, Mao J, Zhang L, Ji R.   +6 more
europepmc   +1 more source

Fractionation of the Histones of the Walker 256 Carcinosarcoma by Combined Chemical and Chromatographic Techniques

, 1963
Lubomir S. Hnilica, Harris Busch, Charles W. Taylor   +2 more
openalex   +1 more source

Effect of Histones and Protamine on the Infectivity of Semliki Forest Virus and its Ribonucleic Acid [PDF]

, 1966
Joanne Connolly
openalex   +1 more source

Compilation analysis of histones and histone genes

Nucleic Acids Research, 1986
openaire   +4 more sources

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Epigenetic regulation espeically histone modifications in breast cancer: A viable and emerging targeted therapeutic strategy. [PDF]

J Cancer
Zhou Y, Liu H, Hong W, Su H, Mu Y, Cheng Y, Wu C, Meng X, Qian D.   +8 more
europepmc   +1 more source

The role of lysine-rich histone in the maintenance of chromatin structure in metaphase chromosomes.

, 1968
A. E. Mirsky, Carolyn J. Burdick, Eric H. Davidson, Virginia C. Littau   +3 more
openalex   +1 more source

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

Impact of lactylation on the pathogenesis of cancer and its clinical application potential (Review). [PDF]

Mol Med Rep
Wang X, Chen J, Wang B, Li Y, Zhou X, Song Y, Miao C, Huang Y.   +7 more
europepmc   +1 more source