Results 271 to 280 of about 157,390 (295)

Therapeutic potential of selective histone deacetylase 3 inhibition

European Journal of Medicinal Chemistry, 2019
Histone deacetylases (HDACs) are closely related to the occurrence and development of a variety of diseases, such as tumor, inflammation, diabetes mellitus, cardiovascular and neurodegenerative diseases. Inhibition of HDACs by developing HDAC inhibitors has achieved significant progress in the treatment of diseases caused by epigenetic abnormalities ...
Lihui, Zhang, Yiming, Chen, Qixiao, Jiang, Weiguo, Song, Lei, Zhang   +4 more
openaire   +2 more sources

Integrative function of histone deacetylase 3 in inflammation

Molecular Biology Reports
Inflammation is a complex biological response triggered when an organism encounters internal or external stimuli. These triggers activate various signaling pathways, leading to the release of numerous inflammatory mediators aimed at the affected tissue.
Junjie Li, Yiyuan Zhai, Min Tang
openaire   +2 more sources

Histone deacetylase 3 (HDAC3) inhibitors as anticancer agents: A review

European Journal of Medicinal Chemistry, 2020
Among different Histone deacetylases (HDACs), histone deacetylase 3 (HDAC3) is an epigenetic drug target which is currently marked as a potential therapeutic strategy to combat various cancers. HDAC3 inhibitors are effective for the treatment of cancers, different neurodegenerative disorders, diabetes mellitus, cardiac diseases, HIV, inflammatory ...
Rajat, Sarkar, Suvankar, Banerjee, Sk Abdul, Amin, Nilanjan, Adhikari, Tarun, Jha   +4 more
openaire   +2 more sources

14-3-3 regulates the nuclear import of class IIa histone deacetylases

Biochemical and Biophysical Research Communications, 2008
Class IIa histone deacetylases (HDACs) form complexes with a class of transcriptional repressors in the nucleus. While screening for compounds that could block the association of HDAC4 with the BTB domain-containing transcriptional repressor Bach2, we discovered that phorbol 12-myristate 13-acetate (PMA) induced the cytoplasmic retention of HDAC4 ...
Tomonori G, Nishino, Masaya, Miyazaki, Hideto, Hoshino, Yoshihiro, Miwa, Sueharu, Horinouchi, Minoru, Yoshida   +5 more
openaire   +2 more sources

HDAC3_VS_assistant: cheminformatics-driven discovery of histone deacetylase 3 inhibitors

Molecular Diversity
Histone deacetylase 3 (HDAC3) inhibitors keep significant therapeutic promise for treating oncological, neurodegenerative, and inflammatory diseases. In this work, we developed robust QSAR regression models for HDAC3 inhibitory activity and acute toxicity (LD50, intravenous administration in mice).
Oleg V, Tinkov, Veniamin Y, Grigorev
openaire   +2 more sources

Histone deacetylases 1, 2 and 3 in nervous system development

Current Opinion in Pharmacology, 2020
Although histone acetylases (HDACS) were initially believed to render chromatin in a transcriptionally repressed state by deacetylating histones, it is now known that they both repress and activate transcription. Moreover, HDACs regulate the activity and/or function of a large number of other cellular proteins localized in the nucleus and cytoplasm ...
openaire   +2 more sources

Anticancer activities of histone deacetylase inhibitors

Nature Reviews Drug Discovery, 2006
Ricky w Johnstone
exaly  

Integrative regulation of physiology by histone deacetylase 3

Nature Reviews Molecular Cell Biology, 2018
Matthew J Emmett, Mitchell A Lazar
exaly  

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

Nature Reviews Cancer, 2006
Saverio Minucci
exaly  

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

Science, 2011
Tao Liu, Zheng Sun, Anne Bugge
exaly