Results 1 to 10 of about 24,258 (228)

Myeloid HDAC3 deletion protects against traumatic optic injury [PDF]

Cell Death Discovery
Traumatic optic neuropathy (TON) occurs due to trauma to the optic nerve, resulting in blindness. Current management focuses primarily on supportive care, highlighting an urgent need to identify novel treatment targets.
Rami A. Shahror, Carol A. Morris, Ashlynn Cunningham, Piyanan Chuesiang, Abdelrahman Y. Fouda   +4 more
doaj   +2 more sources

HDAC3 Regulates Transcriptional Networks Governing Decidualization. [PDF]

FASEB J
HDAC3 orchestrates transcriptional programs essential for uterine decidualization. Loss of HDAC3 disrupts cytoskeletal organization, metabolic signaling, and oxidative stress responses, impairing stromal cell differentiation and decidualization. These alterations compromise uterine receptivity and result in failed embryo implantation.
Nguyen LTK, Tran DN, Nahar S, Kim TH, Jeong JW, Yoo JY.   +5 more
europepmc   +2 more sources

HDAC3 Preserves the primordial follicle reserve by epigenetically suppressing ferroptosis in pregranulosa cells [PDF]

Cellular and Molecular Life Sciences
The non-renewable primordial follicle (PF) pool underlies female reproductive longevity, yet PF numbers decline sharply before puberty for reasons that remain unclear.
Ziqi Chen, Jiantao Guo, Meng Gao, Huarong Wang, Han Cai, Qingfeng Yang, Xinyu Yang, Yi Lin, Zijian Zhu, Shaogang Qin, Yibing Bao, Ting Zhao, Longping Liu, Tengteng Wang, Bo Zhou, Hua Zhang, Jianbin Wang, Hua Guo, Guoliang Xia, Chao Wang   +19 more
doaj   +2 more sources

HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression

Redox Biology, 2023
Acute kidney injury (AKI) progression to chronic kidney disease (CKD) represents a unique renal disease setting characterized by early renal cellular injury and regulated cell death, and later renal fibrosis, of which the critical role and nature of ...
Lijun Zhang, Fang Chen, Jian Dong, Rong Wang, Guangyu Bi, Daoliang Xu, Yingwei Zhang, Yijun Deng, Wenjun Lin, Zhongzhou Yang, Wangsen Cao   +10 more
doaj   +3 more sources

Inositol hexaphosphate promotes intestinal adaptation in short bowel syndrome via an HDAC3-mediated epigenetic pathway

Food & Nutrition Research, 2023
Background: Short bowel syndrome (SBS) has high morbidity and mortality rates, and promoting intestinal adaptation of the residual intestine is a critical treatment.
Weipeng Wang, Ying Wang, Ying Lu, Xinbei Tian, Shanshan Chen, Bo Wu, Jun Du, Yongtao Xiao, Wei Cai   +8 more
doaj   +1 more source

Histone deacetylase 3 regulates microglial function through histone deacetylation

Epigenetics, 2023
As the primary innate immune cells of the brain, microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules.
Laura Meleady, Morgan Towriss, Jennifer Kim, Vince Bacarac, Vivien Dang, Megan E. Rowland, Annie Vogel Ciernia   +6 more
doaj   +1 more source

Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Clinical Epigenetics, 2023
Background Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates protein stability by modulating the ...
Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu, Zhaoyu Hu, Bo Hao, Ning Li, Qing Geng   +7 more
doaj   +1 more source

HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control

Redox Biology, 2023
Sepsis is one common cause of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which is closely associated with high mortality in intensive care units (ICU). Histone deacetylase 3 (HDAC3) serves as an important epigenetic modifying
Ning Li, Bohao Liu, Rui Xiong, Guorui Li, Bo Wang, Qing Geng   +5 more
doaj   +1 more source

Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2

BMC Cancer, 2023
Background Hepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens and higher circumstantial levels of interleukin-6 (IL-6) produced by resident hepatic macrophages. Methods
Yahong Xu, Yongjie Zhu, Zhenru Wu, Shengfu Li, Mingyang Shao, Qing Tao, Qing Xu, Yuwei Chen, Yuke Shu, Menglin Chen, Yongjie Zhou, Yujun Shi   +11 more
doaj   +1 more source

HDAC3 promotes macrophage pyroptosis via regulating histone deacetylation in acute lung injury

iScience, 2023
Summary: Activated inflammation and pyroptosis in macrophage are closely associated with acute lung injury (ALI). Histone deacetylase 3 (HDAC3) serves as an important enzyme that could repress gene expression by mediating chromatin remodeling.
Ning Li, Bohao Liu, Ruyuan He, Guorui Li, Rui Xiong, Tinglv Fu, Donghang Li, Chenzhen Xu, Bo Wang, Qing Geng   +9 more
doaj   +1 more source