Results 1 to 10 of about 3,215 (191)
EGFR–c-Src-Mediated HDAC3 Phosphorylation Exacerbates Invasion of Breast Cancer Cells [PDF]
Cells, 2019 Breast cancer is one of the leading causes of morbidity and mortality among women. Epidermal growth factor receptor (EGFR) and proto-oncogene tyrosine-protein kinase Src (c-Src) are critical components of the signaling pathways that are associated with ...
Seung-Hyun Lee +2 more
exaly +4 more sources
RGFP966 exerts neuroprotective effect via HDAC3/Nrf2 pathway after surgical brain injury in rats
Heliyon, 2023 Background: Histone deacetylase 3 (HDAC3) restores chromatin nucleosomes to a transcriptional repression state, thereby inhibiting gene expression. Studies have found that HDAC3 expression is upregulated in a variety of pathological states of the central
Mu-Yao Wu, Bao-Qi Dang
exaly +4 more sources
BMC Cancer, 2023 Background Hepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens and higher circumstantial levels of interleukin-6 (IL-6) produced by resident hepatic macrophages. Methods
Yahong Xu +11 more
doaj +2 more sources
HDAC3 promotes macrophage pyroptosis via regulating histone deacetylation in acute lung injury
iScience, 2023 Summary: Activated inflammation and pyroptosis in macrophage are closely associated with acute lung injury (ALI). Histone deacetylase 3 (HDAC3) serves as an important enzyme that could repress gene expression by mediating chromatin remodeling.
Ning Li +9 more
doaj +2 more sources
Hepatic HDAC3 Regulates Systemic Iron Homeostasis and Ferroptosis via the Hippo Signaling Pathway
Research, 2023 Histone deacetylases (HDACs) are epigenetic regulators that play an important role in determining cell fate and maintaining cellular homeostasis. However, whether and how HDACs regulate iron metabolism and ferroptosis (an iron-dependent form of cell ...
Hongen Meng +7 more
doaj +2 more sources
An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
Nature Communications, 2017 HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver. Here, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interacts with PROX1, and show that HDAC3 and PROX1 control ...
Sean M. Armour +7 more
doaj +2 more sources
Journal of Cellular Physiology, 2019 The role of histone deacetylase 3 (HDAC3) is to repress the expression of various genes by eliminating acetyl group from histone. Thus, the regulation of HDAC3 activity is essential to maintain cellular homeostasis.
Kyung-Chul Choi +2 more
exaly +2 more sources
Cell Reports, 2018 Summary: Primordial germ cells (PGCs) are fate determined from pluripotent epiblasts. Signaling pathways and transcriptional regulators involved in PGC formation have been identified, but detailed molecular mechanisms of PGC fate determination remains ...
Kentaro Mochizuki +10 more
doaj +2 more sources
Food & Nutrition Research, 2023 Background: Short bowel syndrome (SBS) has high morbidity and mortality rates, and promoting intestinal adaptation of the residual intestine is a critical treatment.
Weipeng Wang +8 more
doaj +1 more source
Histone deacetylase 3 regulates microglial function through histone deacetylation
Epigenetics, 2023 As the primary innate immune cells of the brain, microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules.
Laura Meleady +6 more
doaj +1 more source