Results 11 to 20 of about 3,215 (191)

PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation [PDF]

Cell Death & Disease, 2018
HDAC3 is involved in deacetylation of histone and non-histone proteins, having a key role in the regulation of gene transcription and also in the process of tumorgenesis. However, how HDAC3 is regulated in cancer remains largely unclear.
Xulei Zheng, Yongxin Ma, Yingying Zhang, Hao Tan, Dachang Tao, Yunqiang Liu, Yilu Lu   +6 more
core   +3 more sources

HDAC3 (histone deacetylase 3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008
Review on HDAC3 (histone deacetylase 3), with data on DNA, on the protein encoded, and where the gene is ...
Escaffit, F
core   +3 more sources

Enzyme-independent functions of HDAC3 in the adult heart

Acta Pharmaceutica Sinica B
The cardioprotective effects of histone deacetylase (HDAC) inhibitors (HDIs) are at odds with the deleterious effects of HDAC depletion. Here, we use HDAC3 as a prototype HDAC to address this contradiction.
Sichong Qian, Chen Zhang, Wenbo Li, Shiyang Song, Guanqiao Lin, Zixiu Cheng, Wenjun Zhou, Huiqi Yin, Yueli Wang, Haiyang Li, Ying H. Shen, Zheng Sun   +11 more
doaj   +5 more sources

Hdac3 regulates lymphovenous and lymphatic valve formation [PDF]

Journal of Clinical Investigation, 2017
Lymphedema, the most common lymphatic anomaly, involves defective lymphatic valve development; yet the epigenetic modifiers underlying lymphatic valve morphogenesis remain elusive.
Shin, Masahiro, Keaney, John F. Jr., Trivedi, Chinmay M, Milstone, Zachary J., Lawson, Nathan D., Janardhan, Harish P.   +5 more
core   +5 more sources

HDAC3 and HDAC8 are required for cilia assembly and elongation

Biology Open, 2019
Cilia are extended from mother centrioles in quiescent G0/G1 cells and retracted in dividing cells. Diverse post-translational modifications play roles in the assembly and disassembly of the cilium.
Park, Seon-ah, Yoo, Hyunjeong, Rhee, Kunsoo, Seol, Jae Hong   +3 more
core   +4 more sources

HDAC3: A Multifaceted Modulator in Immunotherapy Sensitization

Vaccines
Histone deacetylase 3 (HDAC3) has emerged as a critical epigenetic regulator in tumor progression and immune modulation, positioning it as a promising target for enhancing cancer immunotherapy.
Yujun Luo, Huiling Zhou, Yuqian Wang, Jiaojiao Chen, Rui Han, Jingdong Gao, Guoyin Zheng, Changquan Ling   +7 more
core   +4 more sources

HDAC3 Is a Master Regulator of mTEC Development [PDF]

Cell Reports, 2016
SummaryThe thymus provides a unique microenvironment enabling development and selection of T lymphocytes. Medullary thymic epithelial cells (mTECs) play a pivotal role in this process by facilitating negative selection of self-reactive thymocytes and the
Jakub Abramson, Ronald N. Cohen, Asaf Sela, Yonatan Herzig, Noam Kadouri, Anthony N. Hollenberg, Yael Goldfarb, Ben Levi   +7 more
core   +4 more sources

Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Clinical Epigenetics, 2023
Background Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates protein stability by modulating the ...
Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu, Zhaoyu Hu, Bo Hao, Ning Li, Qing Geng   +7 more
doaj   +1 more source

HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control

Redox Biology, 2023
Sepsis is one common cause of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which is closely associated with high mortality in intensive care units (ICU). Histone deacetylase 3 (HDAC3) serves as an important epigenetic modifying
Ning Li, Bohao Liu, Rui Xiong, Guorui Li, Bo Wang, Qing Geng   +5 more
doaj   +1 more source

HDAC3 and the molecular brake pad hypothesis [PDF]

Neurobiology of Learning and Memory, 2011
Successful transcription of specific genes required for long-term memory processes involves the orchestrated effort of not only transcription factors, but also very specific enzymatic protein complexes that modify chromatin structure. Chromatin modification has been identified as a pivotal molecular mechanism underlying certain forms of synaptic ...
Susan C, McQuown, Marcelo A, Wood
openaire   +2 more sources