Results 11 to 20 of about 24,258 (228)

PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation [PDF]

Cell Death & Disease, 2018
AbstractHDAC3 is involved in deacetylation of histone and non-histone proteins, having a key role in the regulation of gene transcription and also in the process of tumorgenesis. However, how HDAC3 is regulated in cancer remains largely unclear. Here, we showed that PIWIL2 can interact with HDAC3, leading to stabilization of HDAC3 from ubiquitin ...
Zhang, Yingying, Zheng, Xulei, Tan, Hao, Lu, Yilu, Tao, Dachang, Liu, Yunqiang, Ma, Yongxin   +6 more
openaire   +2 more sources

Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]

, 2020
Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
core   +1 more source

Endocardial HDAC3 is required for myocardial trabeculation

Nature Communications, 2023
Abstract Failure of proper ventricular trabeculation is often associated with congenital heart disease. Support from endocardial cells, including the secretion of extracellular matrix and growth factors is critical for trabeculation.
Jihyun Jang, Mette Bentsen, Ye Jun Kim, Erick Kim, Vidu Garg, Chen-Leng Cai, Mario Looso, Deqiang Li   +7 more
openaire   +5 more sources

Hdac3 regulates lymphovenous and lymphatic valve formation [PDF]

Journal of Clinical Investigation, 2017
Lymphedema, the most common lymphatic anomaly, involves defective lymphatic valve development; yet the epigenetic modifiers underlying lymphatic valve morphogenesis remain elusive. Here, we showed that during mouse development, the histone-modifying enzyme histone deacetylase 3 (Hdac3) regulates the formation of both lymphovenous valves, which maintain
Janardhan, Harish P., Milstone, Zachary J., Shin, Masahiro, Lawson, Nathan D., Keaney, John F. Jr., Trivedi, Chinmay M   +5 more
openaire   +3 more sources

Characterization of a human RPD3 ortholog, HDAC3 [PDF]

Proceedings of the National Academy of Sciences, 1998
Histone acetylation levels in cells result from a dynamic equilibrium between competing histone acetylases and deacetylases. Changes in histone acetylation levels occur during both transcriptional activation and silencing. Cloning of the cDNA for a human histone deacetylase (HDAC1) has shown that it represents a human ortholog of the yeast
Emiliani, Serena, Fischle, W, Van Lint, Carine, Al-Abed, Y, Verdin, Eric   +4 more
openaire   +3 more sources

Coordinated silencing of the Sp1-mediated long noncoding RNA MEG3 by EZH2 and HDAC3 as a prognostic factor in pancreatic ductal adenocarcinoma

Cancer Biology & Medicine, 2020
Objective: Pancreatic ductal adenocarcinoma (PDAC) is a disease with high mortality. Many so-called “junk” noncoding RNAs need to be discovered in PDAC.
Ting Han, Meng Zhuo, Cuncun Yuan, Xiuying Xiao, Jiujie Cui, Guangrong Qin, Liwei Wang, Feng Jiao   +7 more
doaj   +1 more source

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]

, 2012
The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Grez, Manuel, Katryniok, Careen, Metzner, Julia, Pufahl, Laura, Schnur, Nicole, Sorg, Bernd Lothar, Steinhilber, Dieter   +6 more
core   +1 more source

HDAC3 and the molecular brake pad hypothesis [PDF]

Neurobiology of Learning and Memory, 2011
Successful transcription of specific genes required for long-term memory processes involves the orchestrated effort of not only transcription factors, but also very specific enzymatic protein complexes that modify chromatin structure. Chromatin modification has been identified as a pivotal molecular mechanism underlying certain forms of synaptic ...
Susan C, McQuown, Marcelo A, Wood
openaire   +2 more sources

SERPINA3-ANKRD11-HDAC3 pathway induced aromatase inhibitor resistance in breast cancer can be reversed by HDAC3 inhibition

Communications Biology, 2023
AbstractEndocrine resistance is a major challenge for breast cancer therapy. To identify the genes pivotal for endocrine-resistance progression, we screened five datasets and found 7 commonly dysregulated genes in endocrine-resistant breast cancer cells.
Jing Zhou, Mengdi Zhu, Qi Wang, Yiyuan Deng, Nianqiu Liu, Yujie Liu, Qiang Liu   +6 more
openaire   +3 more sources