Enzyme-independent functions of HDAC3 in the adult heart
Acta Pharmaceutica Sinica BThe cardioprotective effects of histone deacetylase (HDAC) inhibitors (HDIs) are at odds with the deleterious effects of HDAC depletion. Here, we use HDAC3 as a prototype HDAC to address this contradiction.
Sichong Qian +11 more
doaj +6 more sources
EGFR–c-Src-Mediated HDAC3 Phosphorylation Exacerbates Invasion of Breast Cancer Cells [PDF]
Cells, 2019 Breast cancer is one of the leading causes of morbidity and mortality among women. Epidermal growth factor receptor (EGFR) and proto-oncogene tyrosine-protein kinase Src (c-Src) are critical components of the signaling pathways that are associated with ...
Seung-Hyun Lee +2 more
exaly +5 more sources
PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation [PDF]
Cell Death & Disease, 2018 HDAC3 is involved in deacetylation of histone and non-histone proteins, having a key role in the regulation of gene transcription and also in the process of tumorgenesis. However, how HDAC3 is regulated in cancer remains largely unclear.
Xulei Zheng +6 more
core +3 more sources
Differential effect of HDAC3 on cytoplasmic and nuclear huntingtin aggregates.
PLoS ONE, 2014 Histone deacetylases (HDACs) are potential therapeutic targets of polyglutamine (pQ) diseases including Huntington's disease (HD) that may function to correct aberrant transcriptional deactivation caused by mutant pQ proteins.
Tatsuo Mano +3 more
doaj +2 more sources
HDAC3 (histone deacetylase 3) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008 Review on HDAC3 (histone deacetylase 3), with data on DNA, on the protein encoded, and where the gene is ...
Escaffit, F
core +3 more sources
Hdac3 regulates lymphovenous and lymphatic valve formation [PDF]
Journal of Clinical Investigation, 2017 Lymphedema, the most common lymphatic anomaly, involves defective lymphatic valve development; yet the epigenetic modifiers underlying lymphatic valve morphogenesis remain elusive.
Shin, Masahiro +5 more
core +5 more sources
Myeloid HDAC3 deletion protects against traumatic optic injury [PDF]
Cell Death DiscoveryTraumatic optic neuropathy (TON) occurs due to trauma to the optic nerve, resulting in blindness. Current management focuses primarily on supportive care, highlighting an urgent need to identify novel treatment targets.
Rami A. Shahror +4 more
doaj +2 more sources
HDAC3: A Multifaceted Modulator in Immunotherapy Sensitization
VaccinesHistone deacetylase 3 (HDAC3) has emerged as a critical epigenetic regulator in tumor progression and immune modulation, positioning it as a promising target for enhancing cancer immunotherapy.
Yujun Luo +7 more
core +4 more sources
HDAC3 Is a Master Regulator of mTEC Development [PDF]
Cell Reports, 2016 SummaryThe thymus provides a unique microenvironment enabling development and selection of T lymphocytes. Medullary thymic epithelial cells (mTECs) play a pivotal role in this process by facilitating negative selection of self-reactive thymocytes and the
Jakub Abramson +15 more
core +5 more sources
HDAC3 as an Immunometabolic Rheostat: Molecular Mechanisms of Deacylation Plasticity, Lactylation Dynamics, and Spatiotemporal Regulation [PDF]
BiomoleculesHistone deacetylase 3 (HDAC3) is a key node linking immunometabolism, chromatin regulation, and inflammatory transcriptional programs. Rather than functioning simply as a nuclear deacetylase, HDAC3 output is jointly shaped by corepressor-complex assembly,
Yifan Bu +5 more
doaj +2 more sources