Results 41 to 50 of about 24,258 (228)
HDAC3 mediates smoking-induced pancreatic cancer
Oncotarget, 2016 Smoking is a major risk factor for developing pancreatic adenocarcinoma (PDAC); however, little is known about the mechanisms involved. Here we employed a genetic animal model of early stages of PDAC that overexpresses oncogenic Kras in the pancreas to investigate the mechanisms of smoking-induced promotion of the disease in vivo.
Edderkaoui, Mouad +13 more
openaire +5 more sources
HDAC3 Is a Master Regulator of mTEC Development [PDF]
Cell Reports, 2016 The thymus provides a unique microenvironment enabling development and selection of T lymphocytes. Medullary thymic epithelial cells (mTECs) play a pivotal role in this process by facilitating negative selection of self-reactive thymocytes and the generation of Foxp3(+) regulatory T cells.
Yael Goldfarb +7 more
openaire +3 more sources
Scientific Reports, 2020 Previous studies examining the role of the histone deacetylase Hdac3 within myeloid cells demonstrated that Hdac3 promotes M2 activation and tissue healing in inflammatory conditions. Since myeloid lineage cells are required for proper bone formation and
David H. H. Molstad +5 more
doaj +1 more source
The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-kappaB [PDF]
, 2012 Histone deacetylase (HDAC) 3, as a cofactor in co-repressor complexes containing silencing mediator for retinoid or thyroid-hormone receptors (SMRT) and nuclear receptor co-repressor (N-CoR), has been shown to repress gene transcription in a variety of ...
Bhaskara, Srividya +17 more
core +1 more source
Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction [PDF]
, 2010 Abnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance.
Adenuga +33 more
core +1 more source
The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
Cell Death and Disease, 2021 Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and ...
Li Ning, Xiong Rui, Wang Bo, Geng Qing
doaj +1 more source
Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior [PDF]
, 2017 Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2 R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is ...
Cheng, Jemmie +11 more
core +1 more source
The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions [PDF]
, 2016 STAT5 interacts with other factors to control transcription, and the mechanism of regulation is of interest as constitutive active STAT5 has been reported in malignancies. Here, LSD1 and HDAC3 were identified as novel STAT5a interacting partners in pro-B
Demmers, J.A.A. (Jeroen) +7 more
core +3 more sources
The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation [PDF]
Frontiers in Immunology, 2015 We previously reported the anti-allergic effect of high molecular weight form of hyaluronic acid (HMW-HA). In doing so, HA targets CD44 and inhibits FcεRI signaling and cross-talk between epidermal growth factor receptor (EGFR) and FcεRI. We previously reported the role of histone deacetylases (HDACs) in allergic inflammation and allergic inflammation ...
Kim, Youngmi +4 more
openaire +3 more sources
Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs
Chemical Communications, 2020 Potent and histone deacetylase 3 (HDAC3)-specific PROTAC XZ9002 is reported here.
Yufeng Xiao +6 more
openaire +3 more sources