Results 41 to 50 of about 18,122 (224)
Scientific Reports, 2020 Previous studies examining the role of the histone deacetylase Hdac3 within myeloid cells demonstrated that Hdac3 promotes M2 activation and tissue healing in inflammatory conditions. Since myeloid lineage cells are required for proper bone formation and
David H. H. Molstad +5 more
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Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Histone deacetylase 3 (HDAC3) can acetylate histones, negatively regulating Neuronal Per-Arnt-Sim domain protein 4 (Npas4) and participating in various pathological processes of central nervous system lesions.
Haiping Gu +7 more
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Journal of Neuroinflammation, 2022 Background Histone deacetylases (HDACs) are believed to exacerbate traumatic brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform responsible for the detrimental effects and the cell types involved remain unknown ...
Yongfang Zhao +9 more
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The Nuclear Envelope Protein Emerin Binds Directly to Histone Deacetylase 3 (HDAC3) and Activates HDAC3 Activity [PDF]
Journal of Biological Chemistry, 2012 Organization of the genome is critical for maintaining cell-specific gene expression, ensuring proper cell function. It is well established that the nuclear lamina preferentially associates with repressed chromatin. However, the molecular mechanisms underlying repressive chromatin formation and maintenance at the nuclear lamina remain poorly understood.
Justin, Demmerle +2 more
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Cancer Biology & Medicine, 2020 Objective: Pancreatic ductal adenocarcinoma (PDAC) is a disease with high mortality. Many so-called “junk” noncoding RNAs need to be discovered in PDAC.
Ting Han +7 more
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Interactions among STAT3, HDAC3 and PP2A [PDF]
, 2009 Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors, and has been reported to be involved in the pathogenesis of various human ...
Ikeda, Osamu +6 more
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HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1 [PDF]
Journal of Biological Chemistry, 2010 HDAC3 is a member of the class I histone deacetylase family that regulates gene expression by deacetylation of histones and non-histone proteins. HDAC3 activity has been shown to be modulated by interaction with the co-repressors NCoR and SMRT. Here, we present evidence that the nuclear protein DBC1 is an endogenous inhibitor of HDAC3.
Claudia C S, Chini +3 more
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Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease
Translational Neuroscience, 2020 Amyloid-beta (Aβ) plaque deposits and neurofibrillary tangles containing tau proteins are the key pathognomonic manifestations of Alzheimer’s disease (AD). Lack of holistic drugs for AD has reinvigorated enthusiasm in the natural product-based therapies.
Li Zhengyu +4 more
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RGFP966 exerts neuroprotective effect via HDAC3/Nrf2 pathway after surgical brain injury in rats
Heliyon, 2023 Background: Histone deacetylase 3 (HDAC3) restores chromatin nucleosomes to a transcriptional repression state, thereby inhibiting gene expression. Studies have found that HDAC3 expression is upregulated in a variety of pathological states of the central
Hai-Ping Gu +7 more
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The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury
Cell Death and Disease, 2021 Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and ...
Li Ning, Xiong Rui, Wang Bo, Geng Qing
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