Results 51 to 60 of about 18,122 (224)

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Angewandte Chemie, EarlyView.
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim   +10 more
wiley   +2 more sources

An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

Nature Communications, 2017
HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver. Here, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interacts with PROX1, and show that HDAC3 and PROX1 control ...
Sean M. Armour, Jarrett R. Remsberg, Manashree Damle, Simone Sidoli, Wesley Y. Ho, Zhenghui Li, Benjamin A. Garcia, Mitchell A. Lazar   +7 more
doaj   +1 more source

20191109 LC3 HDAC3 manuscript_sup.ppt

, 2020
the potential role of LC3B and HDAC3 in hepatic lipid accumulation in both in vivo and in vitro ...
Yuan-Xiang Pan (8025575)
core   +1 more source

Dissecting HDAC3-mediated tumor progression [PDF]

Cancer Biology & Therapy, 2008
Commentary to:HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signalingCassandra A. Godman, Rashmi Joshi, Brendan R. Tierney, Emily Greenspan, Theodore P. Rasmussen, Hsin-wei Wang, Dong-Guk Shin, Daniel W.
openaire   +2 more sources

20200107 LC3 HDAC3 manuscript_sup.ppt

, 2020
The potential role of LC3B and HDAC3 in hepatic lipid accumulation in both in vivo and in vitro ...
Yuan-Xiang Pan (8025575)
core   +1 more source

SERPINA3-ANKRD11-HDAC3 pathway induced aromatase inhibitor resistance in breast cancer can be reversed by HDAC3 inhibition

Communications Biology, 2023
AbstractEndocrine resistance is a major challenge for breast cancer therapy. To identify the genes pivotal for endocrine-resistance progression, we screened five datasets and found 7 commonly dysregulated genes in endocrine-resistant breast cancer cells.
Jing Zhou, Mengdi Zhu, Qi Wang, Yiyuan Deng, Nianqiu Liu, Yujie Liu, Qiang Liu   +6 more
openaire   +3 more sources

HDAC3 deacetylates and activates PGK1.

, 2015
(A, B) PGK1 interacts with HDAC3. Flag-tagged PGK1 was overexpressed in HEK293T cells together with the individual HA-tagged HDAC as indicated. PGK1 protein was purified by IP with Flag beads, following western blot to detect HDACs with a human influenza
Dan Ye (180080), Tengfei Zhang (794004), Leilei Chen (214607), Lixia Liu (447585), Yukun Xia (794008), Yue Xiong (794009), Yi Wang (32470), Kun-Liang Guan (794010), Huaipeng Lin (794006), Lisha Zhou (794007), Yiping Wang (1484218), Chen Yang (207381), Shiwen Wang (132242), Xiufei Chen (794005), Bowen Jiang (794003)   +14 more
core   +1 more source

HDAC3 acts as a negative regulator of angiogenesis

BMB Reports, 2014
Histone deacetylase-3 (HDAC3) is involved in cellular proliferation, apoptosis and transcriptional repression. However, the role of HDAC3 in angiogenesis remains unknown. HDAC3 negatively regulated the expression of angiogenic factors, such as VEGF and plasminogen activator inhibitor-1 (PAI-1). HDAC3 showed binding to promoter sequences of PAI-1. HDAC3
Park, Deokbum, Park, Hyunmi, Kim, Youngmi, Kim, Hyuna, Jeoung, Dooil   +4 more
openaire   +4 more sources

The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression

BMC Neuroscience, 2019
Background Histone deacetylase-3 (HDAC3) promotes neurodegeneration in various cell culture and in vivo models of neurodegeneration but the mechanism by which HDAC3 exerts neurotoxicity is not known.
Anto Sam Crosslee Louis Sam Titus, Dharmendra Sharma, Min Soo Kim, Santosh R. D’Mello   +3 more
doaj   +1 more source

Dynamic monitoring of cognitive impairment and prognostic recurrence risk in patients with stroke by serum HDAC3 and FOXO1: A potential diagnostic approach [PDF]

Journal of Medical Biochemistry
Background: To evaluate the clinical value of dynamically monitoring serum histone deacetylase 3 (HDAC3) and forkhead box protein O1 (FOXO1) levels in evaluating cognitive impairment (CI) in cerebral stroke (CS) patients, to enable early identification ...
Liu Xintong, Wang Lulu, Xiao Bin, Liu Zhengkun, Dou Yue   +4 more
doaj   +1 more source