Results 51 to 60 of about 3,215 (191)

RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro

Drug Design, Development and Therapy, 2020
Xinying Yu, 1 Fan Yang, 2 Hong Jiang, 3 Ling Fan 1 1Second Pediatric Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China; 2Third Neonatal Ward, Shengjing Hospital of ...
Yu X, Yang F, Jiang H, Fan L
doaj  

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Microbiota-derived metabolite promotes HDAC3 activity in the gut [PDF]

Nature, 2020
The coevolution of mammalian hosts and their beneficial commensal microbes has led to development of symbiotic host-microbiota relationships1. Epigenetic machinery permits mammalian cells to integrate environmental signals2; however, how these pathways are fine-tuned by diverse cues from commensal bacteria is not well understood.
Shu-en Wu, Seika Hashimoto-Hill, Vivienne Woo, Emily M. Eshleman, Jordan Whitt, Laura Engleman, Rebekah Karns, Lee A. Denson, David B. Haslam, Theresa Alenghat   +9 more
openaire   +2 more sources

Hdac3 mRNA and protein expression in Hdac3+/− heterozygous mouse brain.

, 2012
(A) Hdac3 mRNA expression levels in 15 week old mouse cortex, cerebellum and striatum are shown as a relative expression ratio to the WT level. Hdac3+/− (red) and Dbl (purple) mice express the mRNA at 50% of the WT (blue) and R6/2 (green) levels in all ...
Gillian P. Bates (135712), Lara Moumné (139215), David Howland (108842), Yingbin Ouyang (185028), Ken Campbell (185020)   +4 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Structure of HDAC3 bound to co-repressor and inositol tetraphosphate [PDF]

Nature, 2012
Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate gene expression by removing acetyl groups from lysine residues in histone tails, resulting in chromatin condensation. The enzymatic activity of most class I HDACs requires recruitment into multi-subunit co-repressor complexes, which are in turn recruited to chromatin by
Watson, PJ, Fairall, L, Santos, GM, Schwabe, JW   +3 more
openaire   +3 more sources

Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression [PDF]

, 2021
Inhibition or targeted deletion of histone deacetylase 3 (HDAC3) is neuroprotective in a variety neurodegenerative conditions, including retinal ganglion cells (RGCs) after acute optic nerve damage.
Maes, Margaret E ; https://orcid.org/, Nickells, Robert W., Schlamp, Cassandra L., Guo, Lian Wang, Pelzel, Heather R., Fehrman, Rachel L., Yang, Huan, Schmitt, Heather M., Huan Yang, Heather R. Pelzel, Rachel L. Fehrman, Lian-Wang Guo, Heather M. Schmitt, Margaret E. Maes, Cassandra L. Schlamp, Robert W. Nickells   +15 more
core   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat.

PLoS ONE, 2010
Histone deacetylase (Hdac)3 is a nuclear enzyme that contributes to epigenetic programming and is required for embryonic development. To determine the role of Hdac3 in bone formation, we crossed mice harboring loxP sites around exon 7 of Hdac3 with mice ...
David F Razidlo, Tiffany J Whitney, Michelle E Casper, Meghan E McGee-Lawrence, Bridget A Stensgard, Xiaodong Li, Frank J Secreto, Sarah K Knutson, Scott W Hiebert, Jennifer J Westendorf   +9 more
doaj   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source