Results 51 to 60 of about 24,258 (228)

An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

Nature Communications, 2017
HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver. Here, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interacts with PROX1, and show that HDAC3 and PROX1 control ...
Sean M. Armour, Jarrett R. Remsberg, Manashree Damle, Simone Sidoli, Wesley Y. Ho, Zhenghui Li, Benjamin A. Garcia, Mitchell A. Lazar   +7 more
doaj   +1 more source

The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages [PDF]

, 2018
The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, but our understanding remains limited regarding the molecular determinants of repression.
Bacsó, Zsolt, Bankó, Csaba, Benkő, Szilvia, Czimmerer, Zsolt, Daniel, B., Horvath, Attila, Nagy, Béla, Nagy, Gergely, Nagy, László, Póliska, Szilárd, Ruckerl, Dominik   +10 more
core   +1 more source

Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy. [PDF]

, 2017
BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle (SV) heart disease ...
A Cevik, A Correa-Villasenor, A deAlmeida, A Granger, A Kulkarni, AP Vlahos, C Scholz, Carlin S Long, CL Antos, D Sedmera, DD Lemon, DJ Cao, Douglas D Lemon, J Lu, JP Cardinale, JW Newburger, JW Rossano, JW Rossano, Karin Nunley, Katharina M Lutter, KB Schuetze, Kimberly M Demos-Davies, KM Demos-Davies, M Tanno, MA Cavasin, MA Cavasin, Maria A Cavasin, MP Gupta, OA O'Connor, PA Marks, PC Frommelt, Q Yang, R Kirk, RG Ohye, S Chen, Sam Payne, SD Miyamoto, SD Miyamoto, SD Miyamoto, Shelley D Miyamoto, SJ Nakano, SK Mani, SM Williams, TA McKinsey, TG Gillette, Timothy A McKinsey, VM Klimek, Weston W Blakeslee, WJ Kowalski, WW Blakeslee   +49 more
core   +1 more source

HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment

eLife, 2019
CD4 and CD8 T cells are vital components of the immune system. We found that histone deacetylase 3 (HDAC3) is critical for the development of CD4 T cells, as HDAC3-deficient DP thymocytes generate only CD8SP thymocytes in mice.
Rachael Laura Philips, Jeong-Heon Lee, Krutika Gaonkar, Pritha Chanana, Ji Young Chung, Sinibaldo R Romero Arocha, Aaron Schwab, Tamas Ordog, Virginia Smith Shapiro   +8 more
doaj   +1 more source

Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis [PDF]

, 2009
OBJECTIVE: We have recently shown a significant reduction in cytokine-induced transcription of type I collagen and fibronectin in systemic sclerosis (SSc) skin fibroblasts upon treatment with trichostatin A (TSA).
Brentano, F, Distler, J H W, Distler, O, Gay, R E, Gay, S, Hemmatazad, H, Huber, L C, Jüngel, A, Maciejewska Rodrigues, H, Maurer, B, Michel, B A, Pileckyte, M   +11 more
core   +1 more source

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR. [PDF]

, 2020
Despite reductions in mortality from the use of highly active antiretroviral therapy (HAART), the presence of latent or transcriptionally silent proviruses prevents HIV cure/eradication.
Bukrinsky, Michael, Dubrovsky, Larisa, Jada, Tejaswi, Ochem, Alex, Sahu, Geetaram, Sharma, Adhikarimayum Lakhikumar, Simon, Gary, Sun, Lin, Tyagi, Mudit, Yue, Han, Zicari, Sonia   +10 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro

Drug Design, Development and Therapy, 2020
Xinying Yu, 1 Fan Yang, 2 Hong Jiang, 3 Ling Fan 1 1Second Pediatric Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China; 2Third Neonatal Ward, Shengjing Hospital of ...
Yu X, Yang F, Jiang H, Fan L
doaj  

Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection

Cell & Bioscience, 2022
Background As important enzymes regulating acetylation, histone deacetylases (HDACs) participate in a series of cell physiological process. However, the mechanisms responsible for individual HDAC family members in regulating innate immunity remained to ...
Liping Yang, Shengchuan Chen, Jingyan Xia, Ying Zhou, Linan Peng, Huimin Fan, Yu Han, Lihua Duan, Genhong Cheng, Heng Yang, Feng Xu   +10 more
doaj   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source