Results 71 to 80 of about 18,122 (224)

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Rg3 decreases HDAC3 expression.

, 2014
(A) Analysis of HDAC3 level by Western blotting in A375 and C8161 cells after cells treated with Rg3 (0, 25, 50 µg/mL) for 72 h. (B) HDAC3 expression level in cells treated with Rg3 (50 µg/mL) for 0, 24, 48 or 72 h. GAPDH was used as an internal control.
Xiu Shan (62157), Yuan-Shan Fu (676596), Qiu Yan (597586), Xiao-Qi Wang (2745565), Faisal Aziz (676597), Ji-Wei Liu (676598)   +5 more
core   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

HDAC3 as a Molecular Chaperone for Shuttling Phosphorylated TR2 to PML: A Novel Deacetylase Activity-Independent Function of HDAC3

PLoS ONE, 2009
TR2 is an orphan nuclear receptor specifically expressed in early embryos (Wei and Hsu, 1994), and a transcription factor for transcriptional regulation of important genes in stem cells including the gate keeper Oct4 (Park et al. 2007). TR2 is known to function as an activator (Wei et al.
Pawan Gupta, Ping-Chih Ho, Sung Gil Ha, Yi-Wei Lin, Li-Na Wei   +4 more
openaire   +4 more sources

HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment

eLife, 2019
CD4 and CD8 T cells are vital components of the immune system. We found that histone deacetylase 3 (HDAC3) is critical for the development of CD4 T cells, as HDAC3-deficient DP thymocytes generate only CD8SP thymocytes in mice.
Rachael Laura Philips, Jeong-Heon Lee, Krutika Gaonkar, Pritha Chanana, Ji Young Chung, Sinibaldo R Romero Arocha, Aaron Schwab, Tamas Ordog, Virginia Smith Shapiro   +8 more
doaj   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.

, 2015
Deciphering the molecular basis of neuronal cell death is a central issue in the etiology of neurodegenerative diseases, such as Parkinson's and Alzheimer's. Dysregulation of p53 levels has been implicated in neuronal apoptosis.
Choi, Y, Kim, YJ, Yoon, HG, Choi, HK, Moon, J, Joe, EH, Choi, I, Kang, H, Lim, EJ, Choi, KC, Park, JM, Lee, HS, Park, SY   +12 more
core   +2 more sources

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

HDAC3 is essential for DNA replication in hematopoietic progenitor cells [PDF]

, 2013
Histone deacetylase 3 (HDAC3) contributes to the regulation of gene expression, chromatin structure, and genomic stability. Because HDAC3 associates with oncoproteins that drive leukemia and lymphoma, we engineered a conditional deletion allele in mice ...
Christina E. Wells, Summers, Alyssa R, Fischer, Melissa A, Chen, Xi, Jonathan F. Kaiser, Srividya Bhaskara, Shilpa Sampathi, Hunt, Aubrey, Jessica W. Luzwick, Mary Ann Thompson, Scott W. Hiebert, Yue Zhao, Zhao, Yue, Kristy R. Stengel, Xi Chen, David Cortez, Wells, Christina E, Stengel, Kristy R, Kaiser, Jonathan F, Melissa A. Fischer, Luzwick, Jessica W, Sampathi, Shilpa, Hiebert, Scott W, Aubrey Hunt, Alyssa R. Summers, Cortez, David, Bhaskara, Srividya, Thompson, Mary Ann   +27 more
core   +1 more source

Epicardial HDAC3 Promotes Myocardial Growth Through a Novel MicroRNA Pathway

, 2022
Background: Establishment of the myocardial wall requires proper growth cues from nonmyocardial tissues. During heart development, the epicardium and epicardium-derived cells instruct myocardial growth by secreting essential factors including FGF ...
Li, Qinshan, Cai, Chen-Leng, Kaushal, Sunjay, Pettit, Sarah M., Li, Deqiang, Song, Guang, Jang, Jihyun, Song, Xiaosu   +7 more
core   +1 more source