Results 81 to 90 of about 18,122 (224)

The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation [PDF]

Frontiers in Immunology, 2015
We previously reported the anti-allergic effect of high molecular weight form of hyaluronic acid (HMW-HA). In doing so, HA targets CD44 and inhibits FcεRI signaling and cross-talk between epidermal growth factor receptor (EGFR) and FcεRI. We previously reported the role of histone deacetylases (HDACs) in allergic inflammation and allergic inflammation ...
Kim, Youngmi, Eom, Sangkyung, Park, Deokbum, Kim, Hyuna, Jeoung, Dooil   +4 more
openaire   +3 more sources

Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion

Molecular Metabolism, 2017
Objective: Histone deacetylases are epigenetic regulators known to control gene transcription in various tissues. A member of this family, histone deacetylase 3 (HDAC3), has been shown to regulate metabolic genes.
Jarrett R. Remsberg, Benjamin N. Ediger, Wesley Y. Ho, Manashree Damle, Zhenghui Li, Christopher Teng, Cristina Lanzillotta, Doris A. Stoffers, Mitchell A. Lazar   +8 more
doaj   +1 more source

Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1

Cancer Cell International, 2022
Background Deacetylation of histones by histone deacetylase 3 (HDAC3) acts importantly in modulating apoptosis, DNA damage and cellular progression. Herein, we aimed to unravel the functional role of HDAC3 in a lethal disease, esophageal squamous cell ...
Yang Yang, Yuan Zhang, Zongxiang Lin, Kai Wu, Zhanfeng He, Dengyan Zhu, Jia Zhao, Chunyang Zhang, Yuxia Fan   +8 more
doaj   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis [PDF]

Journal of Dental Research, 2019
Histone deacetylases (HDACs) are important regulators of gene expression that are aberrantly regulated in several inflammatory and infectious diseases. HDAC inhibitors (HDACi) suppress inflammatory activation of various cell types through epigenetic and non-epigenetic mechanisms, and ameliorate pathology in a mouse model of periodontitis. Activation of
K.B. Lagosz, A. Bysiek, J.M. Macina, G.P. Bereta, M. Kantorowicz, W. Lipska, M. Sochalska, K. Gawron, T. Kaczmarzyk, M. Chomyszyn-Gajewska, G. Fossati, J. Potempa, A.M. Grabiec   +12 more
openaire   +3 more sources

Intestinal Epithelial Memory: From Inflammatory Imprinting to Metabolite‐Shaped Immune Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Intestinal epithelial cells are rapidly renewing barrier cells that maintain compartmentalization between the luminal environment and the mucosal immune system through epithelial transport, antimicrobial defense, secretory programs, and cytokine‐mediated communication.
Wenjing Yang, Tianming Yu, Yingzi Cong
wiley   +1 more source

Histone Deacetylase 3-Mediated Inhibition of microRNA-19a-3p Facilitates the Development of Rheumatoid Arthritis-Associated Interstitial Lung Disease

Frontiers in Physiology, 2020
Histone deacetylase (HDAC) has been implicated in rheumatoid arthritis (RA) progression. We investigated the roles of histone deacetylase 3 (HDAC3) involved in RA-associated interstitial lung disease (ILD) fibrosis. Firstly, we measured the expression of
Hui Yuan, Li Jiao, Nan Yu, Haifeng Duan, Yong Yu, Yanrong Bai   +5 more
doaj   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation.

PLoS ONE, 2014
Malignant melanoma is an aggressive and deadly form of skin cancer, and despite recent advances in available therapies, is still lacking in completely effective treatments. Rg3, a monomer extracted from ginseng roots, has been attempted for the treatment
Xiu Shan, Yuan-Shan Fu, Faisal Aziz, Xiao-Qi Wang, Qiu Yan, Ji-Wei Liu   +5 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source