Results 81 to 90 of about 24,258 (228)

Thyroid hormone receptors and ligand, tissue distribution and sexual behavior [PDF]

, 2018
The thyroid hormones (THs) triiodothyronine (T3) and tetraiodothyronine, or thyroxine (T4), not only dramatically impact on development and differentiation, but also on the sexual and reproductive function.
Carosa, E, Jannini, Ea, Lenzi, A
core   +1 more source

HDAC3: A Multifaceted Modulator in Immunotherapy Sensitization

Vaccines
Histone deacetylase 3 (HDAC3) has emerged as a critical epigenetic regulator in tumor progression and immune modulation, positioning it as a promising target for enhancing cancer immunotherapy. This work comprehensively explores HDAC3’s multifaceted roles, focusing on its regulation of key immune-modulatory pathways such as cGAS-STING, ferroptosis, and
Rui Han, Yujun Luo, Jingdong Gao, Huiling Zhou, Yuqian Wang, Jiaojiao Chen, Guoyin Zheng, Changquan Ling   +7 more
openaire   +3 more sources

Enzyme-independent functions of HDAC3 in the adult heart

Acta Pharmaceutica Sinica B
The cardioprotective effects of histone deacetylase (HDAC) inhibitors (HDIs) are at odds with the deleterious effects of HDAC depletion. Here, we use HDAC3 as a prototype HDAC to address this contradiction.
Sichong Qian, Chen Zhang, Wenbo Li, Shiyang Song, Guanqiao Lin, Zixiu Cheng, Wenjun Zhou, Huiqi Yin, Yueli Wang, Haiyang Li, Ying H. Shen, Zheng Sun   +11 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

HDAC3 inhibition ameliorates spinal cord injury by immunomodulation

Scientific Reports, 2017
AbstractFollowing spinal cord injury (SCI), the innate immune response of microglia and infiltrating macrophages clears up cellular debris and promotes tissue repair, but it also inflicts secondary injury from inflammatory responses. Immunomodulation aimed at maximizing the beneficial effects while minimizing the detrimental roles of the innate ...
Tomoharu Kuboyama, Shalaka Wahane, Yong Huang, Xiang Zhou, Jamie K. Wong, Andrew Koemeter-Cox, Michael Martini, Roland H. Friedel, Hongyan Zou   +8 more
openaire   +3 more sources

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

EMBO Molecular Medicine, 2014
Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management.
Marten A Hoeksema, Marion JJ Gijbels, Jan Van den Bossche, Saskia van der Velden, Ayestha Sijm, Annette E Neele, Tom Seijkens, J Lauran Stöger, Svenja Meiler, Marieke CS Boshuizen, Geesje M Dallinga‐Thie, Johannes HM Levels, Louis Boon, Shannon E Mullican, Nathanael J Spann, Jack P Cleutjens, Chris K Glass, Mitchell A Lazar, Carlie JM de Vries, Erik AL Biessen, Mat JAP Daemen, Esther Lutgens, Menno PJ de Winther   +22 more
doaj   +1 more source

Altered cytoskeletal integrity underlies impaired platelet shape change and defective thrombus formation in ETV6‐related thrombocytopenia

British Journal of Haematology, EarlyView.
Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov, Julia‐Jessica D. Korobkin, Daria V. Fedorova, Sofia V. Galkina, Maria M. Golomysova, Sergei I. Obydennyi, Anastasia A. Ignatova, Ekaterina‐Iva A. Adamanskaya, Eugenia V. Yushkova, Anna V. Pavlova, Pavel A. Zharkov, Igor I. Kireev, Galina A. Novichkova, Viktor G. Zgoda, Mikhail A. Panteleev, Anastasia N. Sveshnikova   +15 more
wiley   +1 more source

Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation [PDF]

, 2018
Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many of these breeds do not excel in important traits but are adapted to local environments.
A Talenti, A Yurchenko, A Zrhidri, AGT Pereira, AK Lindholm-Perry, AR Boyko, AS Wilkins, B Cannon, B Dorshorst, B Grisart, B Haase, B Loureiro, B Loureiro, B Loureiro, BG Oliver, BS Weir, CB Kaelin, D Boruszewska, D Wright, D Yang, DR Schrider, EA Ostrander, EM Ibeagha-Awemu, F Li, F Schlamp, F Tajima, FB Axelrod, G Valverde, H Li, H Li, H Mannen, H Pausch, H Yamada, H Zhang, HD Daetwyler, HD Daetwyler, HP Jedema, I Kurth, I Mathieson, I Naka, I Urbinati, J Kim, J Martin-Tereso, J Queiros, JD Jensen, JD Storey, JE Decker, JJ Simoni Gouveia de, JK Pickrell, K Kim, K Konczol, K Soini, K Wimmers, KC Wollenberg Valero, KE Lotterhos, L Ma, LA Raven, M Cohen-Zinder, M Knoll, M Nei, M Nizon, M Saatchi, MI Fariello, MJ Emmett, MN Weedon, MR Upadhyay, MRS Fortes, NA Mandal, O Delaneau, O Tange, P Danecek, P Scheet, Q Qiu, QL Meng, R Verity, R Weikard, R Xiang, RL Minster, RR Mota, S Boitard, S Bolormaa, S Bongiorni, S Fan, S Makvandi-Nejad, S Moon, S Purcell, S Roth, S Roy, S Sasaki, S Wu, SD Berry, SH Carroll, SJ Yue, SR Grossman, T Iso-Touru, T Nishimaki, TY Yeh, W Barendse, X Zheng, X Zheng, XL Wang, Y Gao, Y Gao, Y Liu, Y Ma, Y Qin, Y Wang, YT Utsunomiya, Z Gu   +108 more
core   +5 more sources

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas [PDF]

Cancer Discovery, 2017
Abstract Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates the development of germinal center (GC)–derived lymphomas in mice. In both human and murine lymphomas, CREBBP loss-of-function resulted in focal depletion of enhancer H3K27 acetylation and aberrant transcriptional ...
Jiang, Yanwen, Ortega-Molina, Ana, Geng, Huimin, Ying, Hsia-Yuan, Hatzi, Katerina, Parsa, Sara, McNally, Dylan, Wang, Ling, Doane, Ashley S, Agirre, Xabier, Teater, Matt, Meydan, Cem, Li, Zhuoning, Poloway, David, Wang, Shenqiu, Ennishi, Daisuke, Scott, David W, Stengel, Kristy R, Kranz, Janice E, Holson, Edward, Sharma, Sneh, Young, James W, Chu, Chi-Shuen, Roeder, Robert G, Shaknovich, Rita, Hiebert, Scott W, Gascoyne, Randy D, Tam, Wayne, Elemento, Olivier, Wendel, Hans-Guido, Melnick, Ari M   +30 more
openaire   +4 more sources