Results 91 to 100 of about 24,258 (228)

Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation.

PLoS ONE, 2014
Malignant melanoma is an aggressive and deadly form of skin cancer, and despite recent advances in available therapies, is still lacking in completely effective treatments. Rg3, a monomer extracted from ginseng roots, has been attempted for the treatment
Xiu Shan, Yuan-Shan Fu, Faisal Aziz, Xiao-Qi Wang, Qiu Yan, Ji-Wei Liu   +5 more
doaj   +1 more source

Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination

Cell Reports, 2018
Summary: Primordial germ cells (PGCs) are fate determined from pluripotent epiblasts. Signaling pathways and transcriptional regulators involved in PGC formation have been identified, but detailed molecular mechanisms of PGC fate determination remains ...
Kentaro Mochizuki, Yohei Hayashi, Tamotsu Sekinaka, Kei Otsuka, Yumi Ito-Matsuoka, Hisato Kobayashi, Shinya Oki, Asuka Takehara, Tomohiro Kono, Noriko Osumi, Yasuhisa Matsui   +10 more
doaj   +1 more source

Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1

Cancer Cell International, 2022
Background Deacetylation of histones by histone deacetylase 3 (HDAC3) acts importantly in modulating apoptosis, DNA damage and cellular progression. Herein, we aimed to unravel the functional role of HDAC3 in a lethal disease, esophageal squamous cell ...
Yang Yang, Yuan Zhang, Zongxiang Lin, Kai Wu, Zhanfeng He, Dengyan Zhu, Jia Zhao, Chunyang Zhang, Yuxia Fan   +8 more
doaj   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB [PDF]

, 2016
Histone deacetylase (HDAC) 3, as a cofactor in co-repressor complexes containing silencing mediator for retinoid or thyroid-hormone receptors (SMRT) and nuclear receptor co-repressor (N-CoR), has been shown to repress gene transcription in a variety of ...
Bhaskara, Srividya, Burstein, Ezra, Dittrich-Breiholz, Oliver, Hiebert, Scott W., Hottiger, Michael O., Jurida, Liane, Kettner-Buhrow, Daniela, Kracht, Michael, Kronich, Petra, Li, Haiying, Müller, Helmut, Newel, Doris, Schmitz, M. Lienhard, Schneider, Heike, Soelch, Johanna, Weber, Axel, Wittwer, Tobias, Ziesché, Elisabeth   +17 more
core  

Funktionelle Charakterisierung der SANT-Domänen des Korepressors N-CoR [PDF]

, 2003
Der Korepressor N-CoR vermittelt die Repression von nukleären Hormonrezptoren in Abwesenheit ihrer Liganden und ist darber hinaus für die embryonale Entwicklung von Säugern entscheidend. N-CoR ist in der Zelle mit Histondeacetylasen (HDACs) komplexiert.
Tiefenbach, Jens
core   +1 more source

HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

Journal of Neuroinflammation, 2019
Background Type 2 diabetes mellitus (T2DM) is a chronic metabolic dysfunction characterized by progressive insulin resistance and hyperglycaemia. Increased blood-brain barrier (BBB) permeability is a critical neurovascular complication of T2DM that ...
Qiuchen Zhao, Fang Zhang, Zhanyang Yu, Shuzhen Guo, Ning Liu, Yinghua Jiang, Eng H. Lo, Yun Xu, Xiaoying Wang   +8 more
doaj   +1 more source

Roles of HDAC3-orchestrated circadian clock gene oscillations in diabetic rats following myocardial ischaemia/reperfusion injury

Cell Death and Disease, 2021
The circadian clock is closely related to the development of diabetes mellitus and cardiovascular disease, and disruption of the circadian clock exacerbates myocardial ischaemia/reperfusion injury (MI/RI).
Zhen Qiu, Hao Ming, Shaoqing Lei, Bin Zhou, Bo Zhao, Yanli Yu, Rui Xue, Zhongyuan Xia   +7 more
doaj   +1 more source

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, EarlyView.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

Circadian Epigenomic Remodeling and Hepatic Lipogenesis: Lessons from HDAC3 [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2011
Circadian rhythms have evolved to anticipate metabolic needs across the 24-h light/dark cycle. This is accomplished by circadian expression of metabolic genes orchestrated by transcription factors through chromatin remodeling and histone modifications. Our recent genome-wide study on histone deacetylase 3 (HDAC3) in mouse liver provides novel insights ...
Z, Sun, D, Feng, L J, Everett, A, Bugge, M A, Lazar   +4 more
openaire   +2 more sources