Results 91 to 100 of about 18,122 (224)

HDAC3 preferably binds to nuclear Htt with long Qs.

, 2014
A: GST-HDAC3 binds directly to either cytoplasmic or nuclear Htt-ex1. GST pull-down assay of E1, E2, E3 (cytoplasm), and N1, N2, N3 (nuclear) HeLa cell lysates is shown. Pulled-down fraction was analyzed by anti-GFP or GST antibodies. *Non-specific band.
Takayoshi Suzuki (172609), Shoji Tsuji (236687), Atsushi Iwata (236689), Tatsuo Mano (656328)   +3 more
core   +1 more source

Bone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification

Drug Design, Development and Therapy, 2020
Limin Zhou,1,* Haojun Wu,2,* Xiang Gao,2,* Xiaoyan Zheng,1 Hang Chen,2 Hailong Li,1 Jun Peng,1 Weichong Liang,1 Wenxing Wang,1 Zuocheng Qiu,3 Anjaneyulu Udduttula,3 Kefeng Wu,1 Lin Li,4 Yuyu Liu,1 Yanzhi Liu1,3 1Guangdong Key Laboratory for Research and ...
Zhou L, Wu H, Gao X, Zheng X, Chen H, Li H, Peng J, Liang W, Wang W, Qiu Z, Udduttula A, Wu K, Li L, Liu Y, Liu Y   +14 more
doaj  

FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma

Journal of Translational Medicine, 2022
FOXA1 is associated with malignant tumors, but the function of FOXA1 in EOC is unclear. HDAC3 can influence the proliferation, migration and invasion ability of EOC.
Tong Lou, Chongdong Liu, Hong Qu, Zhiqiang Zhang, Shuzhen Wang, Huiyu Zhuang   +5 more
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Htt aggregates inhibit HDAC3 activity.

, 2014
A: HDAC3 activity is suppressed upon either cytoplasmic or nuclear Htt-ex1 expression. After two days of transfection in 293T cells, the HDAC3 activity of cellular lysates was measured using a fluorescence-based assay.
Takayoshi Suzuki (172609), Shoji Tsuji (236687), Atsushi Iwata (236689), Tatsuo Mano (656328)   +3 more
core   +1 more source

HDAC3 mediates smoking-induced pancreatic cancer

Oncotarget, 2016
Smoking is a major risk factor for developing pancreatic adenocarcinoma (PDAC); however, little is known about the mechanisms involved. Here we employed a genetic animal model of early stages of PDAC that overexpresses oncogenic Kras in the pancreas to investigate the mechanisms of smoking-induced promotion of the disease in vivo.
Edderkaoui, Mouad, Xu, Shiping, Chheda, Chintan, Morvaridi, Susan, Hu, Robert W, Grippo, Paul J, Mascariñas, Emman, Principe, Daniel R, Knudsen, Beatrice, Xue, Jing, Habtezion, Aida, Uyeminami, Dale, Pinkerton, Kent E, Pandol, Stephen J   +13 more
openaire   +5 more sources

Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3β [PDF]

The Journal of Neuroscience, 2011
Although it is well established that pharmacological inhibitors of classical histone deacetylases (HDACs) are protective in variousin vivomodels of neurodegenerative disease, the identity of the neurotoxic HDAC(s) that these inhibitors target to exert their protective effects has not been resolved. We find that HDAC3 is a protein with strong neurotoxic
Farah H, Bardai, Santosh R, D'Mello
openaire   +2 more sources

Roles of HDAC3-orchestrated circadian clock gene oscillations in diabetic rats following myocardial ischaemia/reperfusion injury

Cell Death and Disease, 2021
The circadian clock is closely related to the development of diabetes mellitus and cardiovascular disease, and disruption of the circadian clock exacerbates myocardial ischaemia/reperfusion injury (MI/RI).
Zhen Qiu, Hao Ming, Shaoqing Lei, Bin Zhou, Bo Zhao, Yanli Yu, Rui Xue, Zhongyuan Xia   +7 more
doaj   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Loss of HDAC3 results in nonreceptive endometrium and female infertility

, 2019
Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus and causes chronic pelvic pain and infertility.
윤호근
core   +1 more source