Results 91 to 100 of about 3,215 (191)

Histone Deacetylase 3 (HDAC3) Activity is Regulated by Interaction with Protein Serine/Threonine Phosphatase 4

, 2010
[[abstract]]Histone deacetylase 3 (HDAC3) is one of four members of the human class I HDACs that regulates gene expression by deacetylation of histones and nonhistone proteins.
Zhang X; Ozawa Y; Lee H; Wen YD; Tan TH; Wadzinski BE; Seto E
core  

RCAN1 binds HDAC3 in HEK293 cells.

, 2014
(A) Where indicated, HEK293 cells were mock-transfected or transfected with plasmids encoding HA-tagged RCAN1 and/or Flag-tagged HDAC3 for 24 hr. Cell lysates were immunoprecipitated using anti-HA and anti-Flag antibodies, and immunocomplexes were ...
Hye Seon Kang (619345), Eunju Im (122867), Yun Ju Lee (619349), Kyung Ah Han (619344), Lang Yoo (619347), Kwang Chul Chung (122870), Woo Hyun Shin (619350), Jee Won Lee (619346), Ahyoung Hong (619348)   +8 more
core   +1 more source

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim   +10 more
wiley   +2 more sources

HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

Journal of Neuroinflammation, 2019
Background Type 2 diabetes mellitus (T2DM) is a chronic metabolic dysfunction characterized by progressive insulin resistance and hyperglycaemia. Increased blood-brain barrier (BBB) permeability is a critical neurovascular complication of T2DM that ...
Qiuchen Zhao, Fang Zhang, Zhanyang Yu, Shuzhen Guo, Ning Liu, Yinghua Jiang, Eng H. Lo, Yun Xu, Xiaoying Wang   +8 more
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Myeloid HDAC3 deletion protects against traumatic optic injury

Cell Death Discovery
Traumatic optic neuropathy (TON) occurs due to trauma to the optic nerve, resulting in blindness. Current management focuses primarily on supportive care, highlighting an urgent need to identify novel treatment targets.
Rami A. Shahror, Carol A. Morris, Ashlynn Cunningham, Piyanan Chuesiang, Abdelrahman Y. Fouda   +4 more
doaj   +1 more source

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

EMBO Molecular Medicine, 2014
Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management.
Marten A Hoeksema, Marion JJ Gijbels, Jan Van den Bossche, Saskia van der Velden, Ayestha Sijm, Annette E Neele, Tom Seijkens, J Lauran Stöger, Svenja Meiler, Marieke CS Boshuizen, Geesje M Dallinga‐Thie, Johannes HM Levels, Louis Boon, Shannon E Mullican, Nathanael J Spann, Jack P Cleutjens, Chris K Glass, Mitchell A Lazar, Carlie JM de Vries, Erik AL Biessen, Mat JAP Daemen, Esther Lutgens, Menno PJ de Winther   +22 more
doaj   +1 more source

HDAC3 전사억제자 복합체들의 다양한 생물학적 기능 규명

, 2010
의과학과/박사[한글] [영문]The reversible acetylation by HDAC and HAT is known to be crucial for the stability of p53 and p53-dependent apoptotic signaling. To unravel the functional significance of HDAC3 involved in apoptosis, the yeast-two hybrid assay was ...
최경철
core  

Binding of MVC to HDAC3:NCOR2.

, 2018
The binding of the first MVC activates HDAC3:NCOR2. The second MVC binding partially inhibits.
Hongwei D. Yu (449208), Gregory A. Polsinelli (260313)   +1 more
core   +1 more source