Results 111 to 120 of about 3,215 (191)
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
CXCR2 blockade potentiates HDAC3 deletion mediated antitumor immunity in colorectal cancer
Cell Death and DiseaseHDAC3 is highly expressed in colorectal cancer (CRC) and associated with poor prognosis. This study reveals that HDAC3 deletion dually regulates chemokine expression through epigenetic mechanisms, promoting CD8⁺ T cell infiltration (via CXCL10) on one ...
Yukun Zhang +9 more
doaj +1 more source
HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge. [PDF]
, 2019 It is known that granulosa cells (GCs) mediate gonadotropin-induced oocyte meiosis resumption by releasing EGF-like factors in mammals, however, the detailed molecular mechanisms remain unclear.
Zhang Meiling +15 more
core +1 more source
Aging Cell, Volume 25, Issue 11, November 2026.This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang +7 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2016 Brain ischemic preconditioning (PC) provides vital insights into the endogenous protection against stroke. Genomic and epigenetic responses to PC condition the brain into a state of ischemic tolerance.
Xiaoyu Yang +3 more
doaj +1 more source
NudC associates with HDAC3 in mitosis and a loss of HDAC3 increases NudC acetylation.
, 2013 (A) Cell cycle synchronization schematic. (B) Whole cell lysates (10 µg) from S, G2, early mitosis (prometaphase-like; P), late mitosis (anaphase and telophase; A), and G1 cell cycle phases are blotted with antibodies as indicated.
David H. Hawke (460602) +4 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley +1 more source
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
Nature Communications, 2017 AbstractHepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Here we show that epigenetic events govern hepcidin expression.
Pasricha, Sant-Rayn +27 more
openaire +7 more sources
Histone deacetylase 3 is required for iNKT cell development
Scientific Reports, 2017 NKT cells are a distinct subset that have developmental requirements that often differ from conventional T cells. Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction in the number of iNKT cells, particularly of NKT1 cells.
Puspa Thapa +4 more
doaj +1 more source
Loss of HDAC3 results in nonreceptive endometrium and female infertility
, 2019 Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus and causes chronic pelvic pain and infertility.
윤호근
core +1 more source