Results 111 to 120 of about 18,122 (224)

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly.

PLoS ONE, 2013
To find histone deacetylase 3 (HDAC3)-selective inhibitors, a series of 504 candidates was assembled using "click chemistry", by reacting nine alkynes bearing a zinc-binding group with 56 azide building blocks in the presence of Cu(I) catalyst. Screening
Takayoshi Suzuki, Yuki Kasuya, Yukihiro Itoh, Yosuke Ota, Peng Zhan, Kaori Asamitsu, Hidehiko Nakagawa, Takashi Okamoto, Naoki Miyata   +8 more
doaj   +1 more source

In cortical neurons HDAC3 suppresses RD4-dependent SMRT export [PDF]

, 2011
The transcriptional corepressor SMRT controls neuronal responsiveness of several transcription factors and can regulate neuroprotective and neurogenic pathways.
Hardingham, Giles, Francesc X. Soriano, Hardingham, Giles E., Soriano Francesc X., Soriano Zaragoza, Francesc X. (Francesc Xavier), Francesc X Soriano, Giles E Hardingham, Giles E. Hardingham, Hardingham Giles E.   +8 more
core   +1 more source

HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications

, 2022
Epigenetic signaling pathways are implicated in tumorigenesis and therefore histone deacetylases (HDACs) represent novel therapeutic targets for cancers, including multiple myeloma (MM).
Mazitschek, Ralph, Sagawa, Morihiko, Grondin, Yohann, Kikuchi, Shannon Adele, Tai, Y-T, Anderson, Kenneth, Harada, Takeshi, Hideshima, Teru, Ohguchi, Hiroto   +8 more
core   +1 more source

Involvement of Hdac3-mediated inhibition of microRNA cluster 17-92 in bronchopulmonary dysplasia development

Molecular Medicine, 2020
Background The incidence of bronchopulmonary dysplasia (BPD), a chronic lung disease of newborns, has been paradoxically rising despite medical advances. Histone deacetylase 3 (Hdac3) has been reported to be a crucial regulator in alveologenesis.
Di Wang, Hui Hong, Xiao-Xia Li, Jing Li, Zhi-Qun Zhang   +4 more
doaj   +1 more source

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

HDAC3 전사억제자 복합체들의 다양한 생물학적 기능 규명

, 2010
의과학과/박사[한글] [영문]The reversible acetylation by HDAC and HAT is known to be crucial for the stability of p53 and p53-dependent apoptotic signaling. To unravel the functional significance of HDAC3 involved in apoptosis, the yeast-two hybrid assay was ...
최경철
core  

RCAN1 binds HDAC3 in HEK293 cells.

, 2014
(A) Where indicated, HEK293 cells were mock-transfected or transfected with plasmids encoding HA-tagged RCAN1 and/or Flag-tagged HDAC3 for 24 hr. Cell lysates were immunoprecipitated using anti-HA and anti-Flag antibodies, and immunocomplexes were ...
Hye Seon Kang (619345), Eunju Im (122867), Yun Ju Lee (619349), Kyung Ah Han (619344), Lang Yoo (619347), Kwang Chul Chung (122870), Woo Hyun Shin (619350), Jee Won Lee (619346), Ahyoung Hong (619348)   +8 more
core   +1 more source

Characterizing NCoR1/HDAC3-Transcription Factor Complexes [PDF]

Aberrant HDAC activity has been linked to the development and progression of certain cancers. This has led to HDACs being seen as clinically relevant drug targets and the development of HDAC inhibitors as anticancer drugs.
Liedtke, Elisabeth
core   +1 more source

Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury

Journal of Neuroinflammation
Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and central retinal artery and vein occlusions.
Rami A. Shahror, Esraa Shosha, Carol Morris, Melissa Wild, Shengyu Mu, Gabor Csanyi, Marjan Boerma, Nancy J. Rusch, Abdelrahman Y. Fouda   +8 more
doaj   +1 more source