Results 121 to 130 of about 24,258 (228)

Curcumin Nanoformulations for Dermatological Applications: From Nutraceuticals to Nanocarriers

Food Frontiers, Volume 7, Issue 3, May 2026.
Nanotechnology‐based delivery platforms enhance the cutaneous administration of curcumin. Loading free curcumin into polymeric micelles, metal‐based nanoparticles, nanogels/hydrogels, liposomes, polymeric nanoparticles, or nanoemulsions/nanocrystals helps address its low solubility, poor stability and limited skin permeation. As a result, these systems
Stephany Celeste Gutiérrez‐Ruiz, Alejandra Romero‐Montero, Hector Hernández‐Parra, Sheila I. Peña‐Corona, Héctor Adrián García‐Gasca, Katya Carbone, Fabio Gervasi, Shivaprasad Shetty Mangalpady, Rajesh Kaverikana, Mariia Shanaida, Volodymyr Shanaida, Daniela Calina, Javad Sharifi‐Rad, Gerardo Leyva‐Gómez   +13 more
wiley   +1 more source

Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance [PDF]

, 2017
Aberrant activation of Hedgehog (HH)/GLI signaling is causally involved in numerous human malignancies, including basal cell carcinoma (BCC) and medulloblastoma. HH pathway antagonists targeting smoothened (SMO), an essential effector of canonical HH/GLI
Aberger, Fritz, Bartz, René, Canettieri, Gianluca, Coni, Sonia, Del Burgo, Pedro, Elmer, Dominik P, Gruber, Wolfgang, Kohlhof, Hella, Neureiter, Daniel, Peer, Elisabeth, Sternberg, Christina, Tesanovic, Suzana, Vitt, Daniel   +12 more
core   +1 more source

Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury

Journal of Neuroinflammation
Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and central retinal artery and vein occlusions.
Rami A. Shahror, Esraa Shosha, Carol Morris, Melissa Wild, Shengyu Mu, Gabor Csanyi, Marjan Boerma, Nancy J. Rusch, Abdelrahman Y. Fouda   +8 more
doaj   +1 more source

Histone deacetylase 3 is required for iNKT cell development

Scientific Reports, 2017
NKT cells are a distinct subset that have developmental requirements that often differ from conventional T cells. Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction in the number of iNKT cells, particularly of NKT1 cells.
Puspa Thapa, Sinibaldo Romero Arocha, Ji Young Chung, Derek B. Sant’Angelo, Virginia Smith Shapiro   +4 more
doaj   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Class I HDAC Inhibition Blocks Cocaine-Induced Plasticity Through Targeted Changes in Histone Methylation [PDF]

, 2014
Induction of histone acetylation in the nucleus accumbens (NAc), a key brain reward region, promotes cocaine-induced alterations in gene expression. Histone deacetylases (HDACs) tightly regulate the acetylation of histone tails, but little is known about
Badimon, Ana, Bassel-Duby, Rhonda, Chaudhury, Dipesh, Damez-Werno, Diane M., Feng, Jian, Haggarty, Stephen J., Han, Ming-Hu, Kennedy, Pamela J., Maze, Ian, Mouzon, Ezekiell, Nestler, Eric J., Olson, Eric N., Robison, A.J.   +12 more
core   +1 more source

The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism [PDF]

, 2012
Skeletal muscle exhibits a high plasticity and accordingly can quickly adapt to different physiological and pathological stimuli by changing its phenotype largely through diverse epigenetic mechanisms.
Pérez-Schindler, Joaquín, Summermatter, Serge, Salatino, Silvia, Zorzato, Francesco, Beer, Markus, Balwierz, Piotr J., van Nimwegen, Erik, Feige, Jérôme N., Auwerx, Johan, Handschin, Christoph   +9 more
core   +5 more sources

Designing potential HDAC3 inhibitors to improve memory and learning

Journal of Biomolecular Structure and Dynamics, 2018
The work presented here explores the structural and physicochemical features important for benzamide-based HDAC3 inhibitors to get an idea about the design aspect of potential inhibitors. A number of molecular modeling studies (3D-QSAR CoMFA and CoMSIA, Bayesian classification modeling) were performed on 113 diverse set of benzamide-based HDAC3 ...
Sk. Abdul Amin, Nilanjan Adhikari, Tarun Jha, Balaram Ghosh   +3 more
openaire   +2 more sources

Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti, Gustavo Salgado Pires, Ana Ryan, Crisamie Regidor, Matthew Hiller, Danilo Sarti, Tríona Ní Chonghaile, Pedro de Sena Murteira Pinheiro, Damir Varešlija, Daniel Alencar Rodrigues   +9 more
wiley   +1 more source

Differential expression of 12 histone deacetylase () genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas [PDF]

, 2008
Background Glioblastoma is the most lethal primary malignant brain tumor. Although considerable progress has been made in the treatment of this aggressive tumor, the clinical outcome for patients remains poor. Histone deacetylases (HDACs)
Agda KB Lucio-Eterovic, Maria AA Cortez, Elvis T Valera, Fabio JN Motta, Rosane GP Queiroz, Helio R Machado, Carlos G Carlotti, Luciano Neder, Carlos A Scrideli, Luiz G Tone, DN Louis, HY Lin, PA Wade, SG Gray, P Gallinari, AJ de Ruijter, Y Zhang, AJ Wilson, CM Grozinger, E Verdin, HY Kao, A Verdel, C Lemercier, EA Miska, AH Wang, G Blander, S Imai, R Marmorstein, L Gao, CA Lopez, K Camphausen, M Entin-Meer, JH Kim, H Sawa, HC Ugur, M Wetzel, UK Laemmli, BH Huang, JH Choi, P Liby, H Ozdag, H Osada, AC Goussia, R Jiang, P Kleihues, A Michotte, HK Ng, D Kolle, D Riester, D Wegener, M Wiren, H Brinkmann, RW Johnstone, MR Acharya, DC Drummond   +54 more
core   +2 more sources