Results 121 to 130 of about 18,122 (224)

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7629-7642, October 2026.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, Volume 600, Issue 17, Page 2437-2450, September 2026.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

KCl regulates HDAC3:NCOR2 catalytic activity.

, 2018
HDAC3:NCOR2 activity and its dependency on KCl concentration was determined by constructing Michaelis-Menten plots (a representative plot is shown in panel A at 5mM [KCl]) at varying concentrations of KCl (0.05 mM-50 mM), Fluor de Lys SIRT1 substrate (1 ...
Hongwei D. Yu (449208), Gregory A. Polsinelli (260313)   +1 more
core   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas [PDF]

, 2017
Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates the development of germinal center (GC)-derived lymphomas in mice.
Hatzi, Katerina, Parsa, Sara, Agirre, Xabier, Ennishi, Daisuke, Jiang, Yanwen, Hiebert, Scott W, Li, Zhuoning, Elemento, Olivier, McNally, Dylan, Gascoyne, Randy D, Tam, Wayne, Poloway, David, Sharma, Sneh, Holson, Edward, Teater, Matt, Chu, Chi-Shuen, Wang, Ling, Shaknovich, Rita, Geng, Huimin, Scott, David W, Melnick, Ari M, Ortega-Molina, Ana, Stengel, Kristy R, Ying, Hsia-Yuan, Young, James W, Wendel, Hans-Guido, Doane, Ashley S, Meydan, Cem, Wang, Shenqiu, Kranz, Janice E, Roeder, Robert G   +30 more
core   +1 more source

Histone deacetylase 3 is required for iNKT cell development

Scientific Reports, 2017
NKT cells are a distinct subset that have developmental requirements that often differ from conventional T cells. Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction in the number of iNKT cells, particularly of NKT1 cells.
Puspa Thapa, Sinibaldo Romero Arocha, Ji Young Chung, Derek B. Sant’Angelo, Virginia Smith Shapiro   +4 more
doaj   +1 more source

Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats

Frontiers in Molecular Neuroscience, 2016
Brain ischemic preconditioning (PC) provides vital insights into the endogenous protection against stroke. Genomic and epigenetic responses to PC condition the brain into a state of ischemic tolerance.
Xiaoyu Yang, Qimei Wu, Lei Zhang, Linyin Feng   +3 more
doaj   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16

, 2018
It has been reported that class I histone deacetylase (HDAC) inhibition increases thermogenesis in fat, but adipocyte-specific Hdac3 deletions have presented inconsistent results.
Jun Wu, Dong-il Kim, Heejin Jun, Margo P Emont, Jiling Liao, Juan Jiang, Xiaona Qiao   +6 more
core   +1 more source

The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro

Frontiers in Physiology, 2019
Osteoarthritis (OA) is a disease characterized by non-bacterial inflammation. Histone deacetylase 3 (HDAC3) is a crucial positive regulator in the inflammation that leads to the development of non-OA inflammatory disease. However, the precise involvement
He Zhang, Lu Ji, Yue Yang, Yingliang Wei, Xiaoning Zhang, Yi Gang, Jinghan Lu, Lunhao Bai   +7 more
doaj   +1 more source