Results 131 to 140 of about 24,258 (228)

An epigenetic blockade of cognitive functions in the neurodegenerating brain [PDF]

, 2011
Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervous system, including Alzheimer’s disease [superscript 1].
Delalle, Ivana, Fass, Daniel M., Graff, Johannes, Guan, Ji-Song, Haggarty, Stephen J., Hennig, Krista M., Joseph, Nadine, Kahn, Martin, Kao, Patricia F., Nieland, Thomas J., Rei, Damien, Samiei, Alireza, Seo, Jinsoo, Su, Susan C., Tsai, Li-Huei, Wang, Wen-Yuan   +15 more
core   +1 more source

Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease.

PLoS ONE, 2012
Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder caused by an expansion of a CAG/polyglutamine repeat for which there are no disease modifying treatments. In recent years, transcriptional dysregulation has emerged
Lara Moumné, Ken Campbell, David Howland, Yingbin Ouyang, Gillian P Bates   +4 more
doaj   +1 more source

A Dual Reporter Mouse Model of the Human β-Globin Locus: Applications and Limitations [PDF]

, 2012
The human β-globin locus contains the β-like globin genes (i.e. fetal γ-globin and adult β-globin), which heterotetramerize with α-globin subunits to form fetal or adult hemoglobin.
Drabek, D.D. (Dubravka), Grosveld, F.G. (Frank), Gutiérrez, L. (Laura), Kong-a-San, J. (John), Linden, R. (Reinier) van der, Maas, A. (Alex), Papadopoulos, P. (Petros), Patrinos, G.P. (George), Philipsen, J.N.J. (Sjaak)   +8 more
core   +1 more source

Retinoic Acid Induced nuclear localization of HDAC3

The FASEB Journal, 2009
Histone deacetylase 3 (HDAC3) plays an important role in regulating transcription, cell cycle progression and developmental events through its deacetylase activity on core histones. Recently, it has been shown HDAC3 has functions independent of its deacetylase activity.
Shawna Devi Persaud, Ping‐Chih Ho, Li‐Na Wei   +2 more
openaire   +1 more source

The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism

Journal of Molecular Cell Biology, 2018
Histone deacetylase 3 (HDAC3) is a major HDAC, whose enzymatic activity is targeted by small molecule inhibitors for treating a variety of conditions. However, its enzymatic activity is largely dispensable for its function in embryonic development and hepatic lipid metabolism.
Shiyang Song, Yefei Wen, Hui Tong, Emanuele Loro, Yingyun Gong, Jidong Liu, Sungguan Hong, Lei Li, Tejvir S Khurana, Maoping Chu, Zheng Sun   +10 more
openaire   +2 more sources

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly

Molecular Cancer, 2011
Background Histone deacetylase (HDAC) inhibitors are currently undergoing clinical evaluation as anti-cancer agents. Dietary constituents share certain properties of HDAC inhibitor drugs, including the ability to induce global histone acetylation, turn ...
Williams David E, Wuth Bradyn, Yu Tian-Wei, Dashwood W Mohaiza, Delage Barbara, Rajendran Praveen, Ho Emily, Dashwood Roderick H   +7 more
doaj   +1 more source

Inhibition of histone deacetylases 3 attenuates imiquimod-induced psoriatic dermatitis via targeting cGAS-STING signaling in keratinocytes

Journal of Translational Medicine
Background Psoriasis is a common chronic inflammatory skin disease characterized by epidermal keratinocyte hyperproliferation and persistent immune activation.
Chong Zeng, Xiujuan Wen, Zibo Wei, Xinhuai Dong   +3 more
doaj   +1 more source

HDAC3 Gene [PDF]

, 2020
openaire   +1 more source

HDAC3 wt Allele [PDF]

, 2020
openaire   +1 more source

Histone deacetylase 3 (HDAC3) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source