Results 131 to 140 of about 18,122 (224)
HDAC3 inhibitors affect proteasome activity.
, 2014 A–C: HDAC3 inhibitors inhibit proteasome activity. Three different HDAC3 inhibitors were added to HeLa cell cultures at the indicated concentrations. After 48 h of incubation, the proteasome activity of 5 µg total protein in a PBS lysate was measured ...
Takayoshi Suzuki (172609) +3 more
core +1 more source
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
Nature Communications, 2017 AbstractHepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Here we show that epigenetic events govern hepcidin expression.
Pasricha, Sant-Rayn +27 more
openaire +7 more sources
Effect of HDAC3 on cytoplasmic and nuclear Htt aggregates.
, 2014 A: Aspartate at the 166th and 168th amino acid of HDAC3 is crucial for its activity. An empty plasmid (–), FLAG tagged wild-type (wt), or D166A + D168A mutant (DA) of HDAC3 were overexpressed in 293T cells.
Takayoshi Suzuki (172609) +3 more
core +1 more source
Effect of atRA and ERK on endogenous complexes with HDAC3.
, 2013 (A) ERK2-dependent association of HDAC3 to TR2 but not PML. ERK2 was inactivated pharmacologically and the atRA-triggered complex formation of HDAC3 with TR2 and PML was monitored.
Li-Na Wei (22736) +4 more
core +1 more source
Habits are negatively regulated by HDAC3 in the dorsal striatum
, 2017 SUMMARYOptimal behavior results from a balance of control between two strategies, one cognitive/goal-directed and one habitual, which rely on the anatomically distinct dorsomedial (DMS) and dorsolateral (DLS) striatum, respectively.
Venuz Y. Greenfield +7 more
core +1 more source
Binding of MVC to HDAC3:NCOR2.
, 2018 The binding of the first MVC activates HDAC3:NCOR2. The second MVC binding partially inhibits.
Hongwei D. Yu (449208) +1 more
core +1 more source
S424 Phosphorylation of HDAC3 promotes its binding with PGK1.
, 2015 (A) HDAC3 knockdown prevents the effect of insulin on changing PGK1 K220 acetylation and enzyme activity. HEK293T cells were transiently transfected with siRNAs against HDAC3.
Dan Ye (180080) +14 more
core +1 more source
Journal of Translational MedicineBackground Psoriasis is a common chronic inflammatory skin disease characterized by epidermal keratinocyte hyperproliferation and persistent immune activation.
Chong Zeng +3 more
doaj +1 more source
HDAC3 Is Required for Pathognomonic Features of Langerhans Cell Histiocytes
, 2023 Langerhans cell histiocytosis (LCH) is a pediatric inflammatory myeloid neoplasm that develops due to dysregulated myeloid cell development. BRAFV600E is the most common disease-causing mutation and constitutively activates the mitogen-activated protein ...
Allen, Carl E +6 more
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