The impact of histone deacetylase inhibition on neurobehavioural outcomes in preclinical models of traumatic and non-traumatic spinal cord injury: a systematic review [PDF]
Frontiers in ImmunologyIntroductionSpinal cord injury (SCI) is a traumatic injury resulting in significant life-changing disability. Elucidating the molecular processes associated with SCI may help to design novel therapeutics targeted at improving patient outcomes.
Natalia M. Jagodzinska +6 more
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Pharmacological HDAC3 inhibition alters memory updating in young and old male mice [PDF]
Frontiers in Molecular NeuroscienceLong-term memories are not stored in a stable state but must be flexible and dynamic to maintain relevance in response to new information. Existing memories are thought to be updated through the process of reconsolidation, in which memory retrieval ...
Chad W. Smies +15 more
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HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis [PDF]
Frontiers in PharmacologyAcute kidney injury (AKI) refers to clinical syndromes culminating in rapidly reduced renal function associated with inflammation and the demise of renal tubular epithelial cells.
Manman Xie +11 more
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A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice [PDF]
Scientific Reports, 2017 Huntington’s disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families.
Nuria Suelves +3 more
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HDAC3 inhibitors induce drug resistance by promoting IL-17 A production by T cells [PDF]
Scientific ReportsHDAC3 has been demonstrated to play a crucial role in the progression of various tumors and the differentiation and development of T cells. However, its impact on peripheral T cells in the development of murine lung cancer remains unclear.
Hao Chen +8 more
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Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer [PDF]
EMBO Molecular Medicine, 2018 AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other.
Yuqian Yan +24 more
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Molecular modeling to simulation: insights into Gaussian QSAR, molecular docking, and DFT for identification of HDAC3 inhibitors for neurocognitive vascular dementia [PDF]
Scientific ReportsVascular dementia is the second most common form of dementia. It is characterized by reduced blood flow in the cerebral cortex due to neurodegeneration and neuroinflammation. Almost 10 crore people will be suffering from it by 2030.
Debojyoti Halder +4 more
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Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Histone deacetylase 3 (HDAC3) can acetylate histones, negatively regulating Neuronal Per-Arnt-Sim domain protein 4 (Npas4) and participating in various pathological processes of central nervous system lesions.
Haiping Gu +7 more
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Inhibition of histone deacetylases 3 attenuates imiquimod-induced psoriatic dermatitis via targeting cGAS-STING signaling in keratinocytes [PDF]
Journal of Translational MedicineBackground Psoriasis is a common chronic inflammatory skin disease characterized by epidermal keratinocyte hyperproliferation and persistent immune activation.
Chong Zeng +3 more
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Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway [PDF]
Journal of Advanced ResearchIntroduction: Kaempferol (KAE) is a flavonoid found in various plants. Recent studies showed that high dietary intake of KAE was associated with a lower risk of myocardial infarction; however, the cardioprotective mechanism of KAE remains unknown ...
Zejun Yue +11 more
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