Results 1 to 10 of about 869 (107)

RGFP966 inhibits activation of AIM2 inflammasomes to promote mitophagy to relieve acute gouty arthritis [PDF]

PLoS ONE
Acute gouty arthritis (AGA) is a common inflammatory joint disease characterized by pain resulting from the deposition of monosodium urate (MSU) crystals into joints and surrounding tissues. RGFP966, a selective inhibitor of histone deacetylases 3 (HDAC3)
Xiuyun Shi
exaly   +4 more sources

Targeting microglia-mediated neuroinflammation via pH-responsive lipid nanoparticle delivery of HDAC inhibitor RGFP966 in ischemic stroke [PDF]

Science and Technology of Advanced Materials
Ischemic stroke (IS) remains a leading cause of global disability and mortality, with limited effective anti-inflammatory interventions. Targeting histone deacetylase 3 (HDAC3) to reprogram microglial polarization holds great therapeutic promise, but the
Yaqi Liu, Biao Luo, Yun Xu, Dexiang Liu, Qiujing Wang   +4 more
exaly   +5 more sources

RGFP966 exerts neuroprotective effect via HDAC3/Nrf2 pathway after surgical brain injury in rats

Heliyon, 2023
Background: Histone deacetylase 3 (HDAC3) restores chromatin nucleosomes to a transcriptional repression state, thereby inhibiting gene expression. Studies have found that HDAC3 expression is upregulated in a variety of pathological states of the central
Hai-Ping Gu, Xiao-Feng Wu, Ya-Ting Gong, Mu-Yao Wu, Meng-Ying Shi, Ya-ming Sun, Bao-Qi Dang, Gang Chen   +7 more
exaly   +5 more sources

HDAC3 Inhibitor RGFP966 Modulates Neuronal Memory for Vocal Communication Signals in a Songbird Model [PDF]

Frontiers in Systems Neuroscience, 2017
Epigenetic mechanisms that modify chromatin conformation have recently been under investigation for their contributions to learning and the formation of memory. For example, the role of enzymes involved in histone acetylation are studied in the formation
Mark M Gergues, Mimi Phan, Kasia Bieszczad   +2 more
exaly   +5 more sources

Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway [PDF]

Burns and Trauma
Abstract Background Oxidative stress (OS) and inflammatory reactions play pivotal roles in secondary brain injury after traumatic brain injury (TBI). Histone deacetylase 3 (HDAC3) controls the acetylation of histones and non-histones, which has a significant impact on the central nervous system’s ...
Xu L, An T, Jia B, Wu Q, Shen J, Jin J, Liu J, Li C.   +7 more
exaly   +4 more sources

RGFP966 inactivation of the YAP pathway attenuates cardiac dysfunction induced by prolonged hypothermic preservation

Journal of Zhejiang University: Science B, 2020
Oxidative stress and apoptosis are the key factors that limit the hypothermic preservation time of donor hearts to within 4-6 h. The aim of this study was to investigate whether the histone deacetylase 3 (HDAC3) inhibitor RGFP966 could protect against cardiac injury induced by prolonged hypothermic preservation.
Yue-Liang Shen, Linlin Wang, Ying-Ying Chen   +2 more
exaly   +4 more sources

HDAC3 inhibitor RGFP966 controls bacterial growth and modulates macrophage signaling during Mycobacterium tuberculosis infection

Tuberculosis, 2021
Host-directed therapeutics for Mycobacterium tuberculosis (Mtb) offer potential strategies for combatting antibiotic resistance and for killing non-replicating bacilli. Phenylbutyrate, a partially selective histone-deacetylase (HDAC) inhibitor, was previously shown to control Mtb growth and alter macrophage inflammatory pathways at 2-4 mM ...
W Henry Boom, Sarah Heater, Jason Simmons   +2 more
exaly   +4 more sources

HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis [PDF]

Frontiers in Pharmacology
Acute kidney injury (AKI) refers to clinical syndromes culminating in rapidly reduced renal function associated with inflammation and the demise of renal tubular epithelial cells.
Manman Xie, Manman Xie, Rui Hou, Runrun Shan, Xinyu Cheng, Pengcheng Wu, Xiufeng Luo, Yangyang Wei, Li Gao, Xiaoying Liu, Xiaoying Liu, Qi Chen   +11 more
doaj   +2 more sources

HK2 drives synaptic dysfunction in fragile X syndrome via epigenetic regulation of H3K18 lactylation [PDF]

Frontiers in Pharmacology
IntroductionFragile X syndrome (FXS) is a neurodevelopmental disorder caused by loss of fragile X messenger ribonucleoprotein (FMRP) expression and characterized by synaptic dysfunction and cognitive impairment.
Yan Luan, Hanyue Zhang, Ningning Ma, Yuming Zhang, Zhao Xu, Weihua Zhang, Xinyuan Zhang, Yingfei Liu   +7 more
doaj   +2 more sources

RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro

Drug Design, Development and Therapy, 2020
Xinying Yu, 1 Fan Yang, 2 Hong Jiang, 3 Ling Fan 1 1Second Pediatric Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China; 2Third Neonatal Ward, Shengjing Hospital of ...
Yu X, Yang F, Jiang H, Fan L
doaj   +4 more sources