Results 41 to 50 of about 1,119 (155)

The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors [PDF]

, 2018
Histone deacetylases (HDACs) are epigenetic drug targets that have gained major scientific attention. Inhibition of these important regulatory enzymes is used to treat cancer, and has the potential to treat a host of other diseases.
Cao, Fangyuan, Dekker, Frank J, Zwinderman, Martijn R H   +2 more
core   +2 more sources

The Effects of Selective Inhibition of Histone Deacetylase 1 and 3 in Huntington’s Disease Mice [PDF]

, 2021
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease characterized by a late clinical onset of psychiatric, cognitive, and motor symptoms.
Boehm-Sturm, Philipp, Harms, Christoph, Hecklau, Katharina, Kilic, Busra, Koch, Stefan Paul, Mehkary, Mustafa Hussain, Mueller, Susanne, Yildirim, Ferah   +7 more
core   +1 more source

Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway

Pharmaceutical Biology, 2023
Context di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing formulations (BSTJFs) are beneficial for female reproductive capacity.
Hui Zhang, Huihua Wang, Qing Zhang, Hui Wang, Yuhang Zhu, Fangfang Wang, Jun Lin, Jue Zhou, Fan Qu   +8 more
doaj   +1 more source

HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control

Redox Biology, 2023
Sepsis is one common cause of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which is closely associated with high mortality in intensive care units (ICU). Histone deacetylase 3 (HDAC3) serves as an important epigenetic modifying
Ning Li, Bohao Liu, Rui Xiong, Guorui Li, Bo Wang, Qing Geng   +5 more
doaj   +1 more source

Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice [PDF]

, 2019
The orphan nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammatory-related gene transcription in astroglioma cells, but their role in nociceptive transduction has yet to be elaborated.
Hisaoka-Nakashima, Kazue, Kodama, Keitaro, Morioka, Norimitsu, Nakamura, Yoki, Nakata, Yoshihiro, Saeki, Munenori, Tomori, Mizuki, Yoshikawa, Kanade, Zhang, Fang Fang   +8 more
core   +1 more source

The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice.

PLoS ONE, 2016
An important epigenetic modification in Huntington's disease (HD) research is histone acetylation, which is regulated by histone acetyltransferase and histone deacetylase (HDAC) enzymes.
Haiqun Jia, Ying Wang, Charles D Morris, Vincent Jacques, Joel M Gottesfeld, James R Rusche, Elizabeth A Thomas   +6 more
doaj   +1 more source

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-kappa B-mediated inflammation [PDF]

, 2016
Activation of inflammatory gene expression is regulated, among other factors, by post-translational modifications of histone proteins. The most investigated type of histone modifications is lysine acetylations.
Dekker, Frank J., Leus, Niek G. J., Zwinderman, Martijn R. H.   +2 more
core   +1 more source

Cognitive Dysfunction in Huntington's Disease: Mechanisms and Therapeutic Strategies Beyond BDNF [PDF]

, 2016
One of the main focuses in Huntington's disease (HD) research, as well as in most of the neurodegenerative diseases, is the development of new therapeutic strategies, as currently there is no treatment to delay or prevent the progression of the disease ...
Abel, Alarcon, Alberch, Andre, Apostol, Arregui, Backman, Baquet, Barco, Barrett, Bates, Begeti, Behr, Bender, Benito, Berrios, Bezprozvanny, Bezprozvanny, Bibb, Bibel, Bliss, Blokland, Boll, Boolell, Bourtchouladze, Bourtchuladze, Bowles, Brito, Brito, Brooks, Brooks, Brooks, Brooks, Brooks, Brooks, Brooks, Buren, Burgess, Cahill, Caramins, Carter, Ceni, Cepeda, Cepeda, Cepeda, Cepeda, Cepeda, Chan, Chang, Chaturvedi, Chen, Chiba, Chrivia, Clarke, Colomer, Coulson, Cummings, Cummings, Cummings, Cummings, Cybulska-Klosowicz, Davies, Deckel, Deckel, Deckel, Deng, Desplats, Di, Diaz-Hernandez, DiFiglia, Dubnau, Dumas, Ehrnhoefer, Eichenbaum, Eichenbaum, Estrada-Sanchez, Estrada-Sanchez, Fan, Fan, Fan, Ferrante, Ferrante, Ferrer, Ferreri, Fossale, Friedman, Gafni, Gardian, Gharami, Ghilan, Giampa, Giampa, Gines, Gines, Gines, Gines, Giralt, Giralt, Giralt, Giralt, Giralt, Giralt, Gladding, Gonzales, Gorski, Graveland, Gray, Greferath, Gruart, Gu, Gu, Hahn-Barma, Harrington, Hebb, Heck, Heckman, Herndon, Hickey, Ho, Hodges, Hodgson, Hong, Hult, Ille, Jarabek, Jia, Jia, Jiang, Joshi, Kalkhoven, Kandel, Kandel, Kandel, Kassubek, Kehoe, Kelly, Kennedy, Kessels, Killoran, Kim, Klapstein, Kleiman, Kleppisch, Korzus, Kumar, Kwok, Labbadia, Laforet, Lawrence, Lawrence, Lawrence, Lee, Lee, Lee, Lee, Lemiere, Lerner, Levine, Levine, Li, Li, Li, Li, Li, Lin, Lione, Lonze, Lonze, Lu, Luthi-Carter, Luthi-Carter, Lynch, Lynch, Ma, Ma, MacPhee, Mangiarini, Mansuy, Marco, Marder, Marti, Mayford, Mazarakis, McBride, McCampbell, Meade, Menalled, Menalled, Metzler, Miguez, Miller, Milnerwood, Milnerwood, Milnerwood, Mitsuishi, Montaldi, Montoya, Morton, Morton, Murmu, Murphy, Nguyen, Niccolini, Nithianantharajah, Norris, Nucifora, Numakawa, Ogryzko, Oike, Orth, Padovan-Neto, Paoletti, Papoutsi, Papp, Parker, Parker, Paulsen, Paulsen, Paulsen, Peixoto, Penzes, Penzes, Penzes, Perez-Otano, Perez-Severiano, Pineda, Plotkin, Plotkin, Politis, Poo, Popoli, Popoli, Popugaeva, Poudel, Poudel, Pouladi, Pouladi, Puerta, Puigdellivol, Putney, Puzzo, Raamsdonk, Raamsdonk, Raamsdonk, Raamsdonk, Raamsdonk, Radhakrishnan, Ramaswamy, Ravnskjaer, Raymond, Reiner, Roberts, Rocher, Rosas, Rosas, Rosch, Rosenberg, Rosenfeld, Rossi, Rouaux, Roze, Rue, Runne, Russell, Saavedra, Saavedra, Saavedra, Sadri-Vakili, Sapp, Sapp, Saura, Schaffar, Schilling, Schippling, Schneider, Seo, Sepers, Seredenina, Shepherd, Shirasaki, Silva, Simmons, Siuciak, Skaper, Slow, Smith, Song, Sotrel, Spampanato, Spargo, Spires, Stack, Steffan, Steffan, Stout, Stout, Sugars, Sun, Suopanki, Tang, Tang, Taylor, Thakur, The Huntington's Disease Collaborative Research Group, Thierry, Threlfell, Threlfell, Troy, Trueman, Turmaine, Tyebji, Unschuld, Valor, Vecsey, Verny, Victorson, Vo, Voermans, von Bohlen Und, Vonsattel, Vonsattel, Wang, Wheeler, Wheeler, Wheeler, Wheeler, Wong, Woo, Wood, Wu, Wu, Wu, Xie, Xie, Xifro, Xifro, Xifro, Xu, Yamamoto, Yamashita, Yhnell, Yhnell, Yu, Zagrebelsky, Zakzanis, Zee, Zhang, Zuccato, Zuccato, Zuccato, Zuccato, Zuccato, Zuccato, Zuccato   +353 more
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Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension.

PLoS ONE, 2019
OBJECTIVE:Non-selective histone deacetylase (HDAC) inhibitors are known to improve hypertension. Here, we investigated the therapeutic effect and regulatory mechanism of the class I HDAC selective inhibitors, MS-275 and RGFP966, in angiotensin (Ang) II ...
Yuhee Ryu, Hae Jin Kee, Simei Sun, Young Mi Seok, Sin Young Choi, Gwi Ran Kim, Seung-Jung Kee, Marc Pflieger, Thomas Kurz, Hyung-Seok Kim, Myung Ho Jeong   +10 more
doaj   +1 more source

Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Clinical Epigenetics, 2023
Background Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates protein stability by modulating the ...
Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu, Zhaoyu Hu, Bo Hao, Ning Li, Qing Geng   +7 more
doaj   +1 more source