Results 21 to 30 of about 888 (124)

Unraveling the role of HDAC3 as an immunotherapy prognostic biomarker and therapeutic target in advanced non-small cell lung cancer [PDF]

Respiratory Research
Background This study investigates HDAC3 as a potential immunotherapy biomarker in advanced non-small cell lung cancer (aNSCLC), focusing on its association with treatment response to immune checkpoint inhibitors (ICIs). Methods We employed a multi-phase
Liyuan Dai, Liling Huang, Lin Li, Le Tang, Yuankai Shi, Xiaohong Han   +5 more
doaj   +2 more sources

The impact of histone deacetylase inhibition on neurobehavioural outcomes in preclinical models of traumatic and non-traumatic spinal cord injury: a systematic review [PDF]

Frontiers in Immunology
IntroductionSpinal cord injury (SCI) is a traumatic injury resulting in significant life-changing disability. Elucidating the molecular processes associated with SCI may help to design novel therapeutics targeted at improving patient outcomes.
Natalia M. Jagodzinska, Caleb Cole, Jamie Brannigan, Renuka Chintapalli, Benjamin M. Davies, Mark R. Kotter, Oliver D. Mowforth   +6 more
doaj   +2 more sources

Pharmacological HDAC3 inhibition alters memory updating in young and old male mice [PDF]

Frontiers in Molecular Neuroscience
Long-term memories are not stored in a stable state but must be flexible and dynamic to maintain relevance in response to new information. Existing memories are thought to be updated through the process of reconsolidation, in which memory retrieval ...
Chad W. Smies, Chad W. Smies, Lauren Bellfy, Lauren Bellfy, Destiny S. Wright, Destiny S. Wright, Sofia G. Bennetts, Sofia G. Bennetts, Mark W. Urban, Mark W. Urban, Chad A. Brunswick, Chad A. Brunswick, Guanhua Shu, Guanhua Shu, Janine L. Kwapis, Janine L. Kwapis   +15 more
doaj   +2 more sources

Inhibition of HDAC3 Expression Alleviates High-Glucose-Induced Photoreceptor Cell Apoptosis and Oxidative Stress. [PDF]

J Diabetes Res
Background Diabetic retinopathy (DR), the most common ocular complication of diabetes mellitus, is a leading cause of blindness among the working‐age population. Its pathogenesis is mainly related to blood–retinal barrier destruction, inflammation, retinal neuron damage, oxidative stress, and genetic immune factors.
Fang Q, Li J, Liu B, Ma Y, Liu J, Lin Q, Ling L, Feng S.   +7 more
europepmc   +2 more sources

82: A Custom Epidrug Crispr Knockout Screen Identifies Rgfp966 (Hdac3 Inhibitor) As A Radiosensitizer of Small Cell Lung Cancer

Radiotherapy and Oncology, 2020
Benjamin Lok
exaly   +2 more sources

The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome [PDF]

The FASEB Journal, 2019
Abstract Histone deacetylases 3 (HDAC3) modulates the acetylation state of histone and non‐histone proteins and could be a powerful regulator of the inflammatory process in stroke. Inflammasome activation is a ubiquitous but poorly understood consequence of acute ischemic stroke.
Mei-Juan, Zhang, Qiu-Chen, Zhao, Ming-Xu, Xia, Jian, Chen, Yan-Ting, Chen, Xiang, Cao, Yi, Liu, Zeng-Qiang, Yuan, Xiao-Ying, Wang, Yun, Xu   +9 more
openaire   +2 more sources

Targeting HDAC3 Suppresses Ferroptosis and Demyelination in White Matter Injury by Restoring PDK4-Mediated Iron Homeostasis. [PDF]

CNS Neurosci Ther
Targeting the HDAC3‐PDK4 axis mitigated demyelinating‐induced ferroptosis. Iron metabolism disorder is not only a secondary phenomenon of demyelination, but also a vicious cycle through the activation of ferroptosis. Iron overload drives lipid peroxidation, triggering oligodendrocyte death and subsequent iron release, which amplifies oxidative damage ...
Xu T, Ye L, Li W, Liu F, Wei T, Gu W, Xu L, Fang M, Luo Q, Wu C, Wang G.   +10 more
europepmc   +2 more sources

HDAC3 Contributes to Ischemic Stroke by Regulating Interferon Pathway

Journal of Integrative Neuroscience, 2023
Background: The inflammation and immune response contribute to ischemic stroke pathology. Damaged brain cells release inflammatory substances to activate the immune system in the acute phase of stroke, including altering the interferon signaling pathway.
Jiaxin Wang, Mengmeng Yang, Yang Chen, Yankuo Liu, Haoliang Zhang, Ruijia Tian, Wujie Zhao, Hongrui Zhu, Sheng Wang   +8 more
doaj   +1 more source

HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression

Redox Biology, 2023
Acute kidney injury (AKI) progression to chronic kidney disease (CKD) represents a unique renal disease setting characterized by early renal cellular injury and regulated cell death, and later renal fibrosis, of which the critical role and nature of ...
Lijun Zhang, Fang Chen, Jian Dong, Rong Wang, Guangyu Bi, Daoliang Xu, Yingwei Zhang, Yijun Deng, Wenjun Lin, Zhongzhou Yang, Wangsen Cao   +10 more
doaj   +1 more source

High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors

Frontiers in Oncology, 2022
Epigenetic modification of chromatin is involved in non-malignant pituitary neoplasia by causing abnormal expression of tumor suppressors and oncogenes.
Wenxiu Zhao, Xiaobin Jiang, Karrin Weisenthal, Jun Ma, Erin M. Botticelli, Yunli Zhou, E. Tessa Hedley-Whyte, Baiyao Wang, Brooke Swearingen, Roy J. Soberman, Anne Klibanski, Xun Zhang   +11 more
doaj   +1 more source