Results 21 to 30 of about 1,119 (155)

Targeting HDAC3 Suppresses Ferroptosis and Demyelination in White Matter Injury by Restoring PDK4-Mediated Iron Homeostasis. [PDF]

CNS Neurosci Ther
Targeting the HDAC3‐PDK4 axis mitigated demyelinating‐induced ferroptosis. Iron metabolism disorder is not only a secondary phenomenon of demyelination, but also a vicious cycle through the activation of ferroptosis. Iron overload drives lipid peroxidation, triggering oligodendrocyte death and subsequent iron release, which amplifies oxidative damage ...
Xu T, Ye L, Li W, Liu F, Wei T, Gu W, Xu L, Fang M, Luo Q, Wu C, Wang G.   +10 more
europepmc   +2 more sources

Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3 [PDF]

, 2022
Acute myeloid leukemia (AML) with mutations in the FMS-like tyrosine kinase (FLT3) is a clinically unresolved problem. AML cells frequently have a dysregulated expression and activity of epigenetic modulators of the histone deacetylase (HDAC) family ...
Beyer, Mandy, Brachetti, Christina, Brenner, Walburgis, Dzulko, Melanie, Haehnel, Patricia S., Henninger, Sven J., Kindler, Thomas, Krämer, Oliver H., Mahboobi, Siavosh, Mustafa, Al-Hassan M., Nikolova, Teodora, Piée-Staffa, Andrea, Sellmer, Andreas, Wachholz, Vanessa, Zeyn, Yanira   +14 more
core   +1 more source

HDAC3 inhibitor RGFP966 controls bacterial growth and modulates macrophage signaling during Mycobacterium tuberculosis infection

Tuberculosis, 2021
Host-directed therapeutics for Mycobacterium tuberculosis (Mtb) offer potential strategies for combatting antibiotic resistance and for killing non-replicating bacilli. Phenylbutyrate, a partially selective histone-deacetylase (HDAC) inhibitor, was previously shown to control Mtb growth and alter macrophage inflammatory pathways at 2-4 mM ...
Monica Campo, Sarah Heater, Glenna J. Peterson, Jason D. Simmons, Shawn J. Skerrett, Harriet Mayanja-Kizza, Catherine M. Stein, W. Henry Boom, Thomas R. Hawn   +8 more
openaire   +3 more sources

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. [PDF]

, 2017
Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis.
Al-Hourani, Kinda, Arezes, João, Armitage, Andrew E, Ashley, Neil, Casu, Carla, Da Silva, Ana Rita, Drakesmith, Hal, Draper, Simon J, Duarte, Tiago L, Frost, Joe N, Gooding, Sarah, Gray, Nicki, Hughes, Jim R, Lim, Pei Jin, McHugh, Kirsty, Milne, Thomas A, Mleczko-Sanecka, Katarzyna, Muckenthaler, Martina U, Olinga, Peter, Oosterhuis, Dorenda, Pasricha, Sant-Rayn, Porto, Graça, Repapi, Emmanouela, Rivella, Stefano, Santos, Ana, Soilleux, Elizabeth, Suciu, Maria, Wray, Katherine   +27 more
core   +14 more sources

The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG [PDF]

, 2023
The ERG (ETS-related gene) transcription factor is linked to various types of cancer, including leukemia. However, the specific ERG domains and co-factors contributing to leukemogenesis are poorly understood. Drug targeting a transcription factor such as
Aqaqe, Nasma, Birger, Yehudit, Bourquin, Jean-Pierre, Chen, Chun-Wei, Drakul, Aneta, Fishman, Hila, Geron, Ifat, Izraeli, Shai, Kugler, Eitan, Liedke, Elisabeth, Liu, Qiao, Madiwale, Shreyas, Milyavsky, Michael, Ogana, Heather, Pimanda, John, Priebe, Valdemar, Privé, Gilbert G, Raught, Brian, Rein, Avigail, Schmoellerl, Johannes, Sykes, David B, Thoms, Julie A I, Yassin, Muhammad, Yong, Darren, Zuber, Johannes   +24 more
core   +1 more source

The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome [PDF]

The FASEB Journal, 2019
Abstract Histone deacetylases 3 (HDAC3) modulates the acetylation state of histone and non‐histone proteins and could be a powerful regulator of the inflammatory process in stroke. Inflammasome activation is a ubiquitous but poorly understood consequence of acute ischemic stroke.
Mei-Juan, Zhang, Qiu-Chen, Zhao, Ming-Xu, Xia, Jian, Chen, Yan-Ting, Chen, Xiang, Cao, Yi, Liu, Zeng-Qiang, Yuan, Xiao-Ying, Wang, Yun, Xu   +9 more
openaire   +2 more sources

HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression

Redox Biology, 2023
Acute kidney injury (AKI) progression to chronic kidney disease (CKD) represents a unique renal disease setting characterized by early renal cellular injury and regulated cell death, and later renal fibrosis, of which the critical role and nature of ...
Lijun Zhang, Fang Chen, Jian Dong, Rong Wang, Guangyu Bi, Daoliang Xu, Yingwei Zhang, Yijun Deng, Wenjun Lin, Zhongzhou Yang, Wangsen Cao   +10 more
doaj   +1 more source

HDAC3 Contributes to Ischemic Stroke by Regulating Interferon Pathway

Journal of Integrative Neuroscience, 2023
Background: The inflammation and immune response contribute to ischemic stroke pathology. Damaged brain cells release inflammatory substances to activate the immune system in the acute phase of stroke, including altering the interferon signaling pathway.
Jiaxin Wang, Mengmeng Yang, Yang Chen, Yankuo Liu, Haoliang Zhang, Ruijia Tian, Wujie Zhao, Hongrui Zhu, Sheng Wang   +8 more
doaj   +1 more source

High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors

Frontiers in Oncology, 2022
Epigenetic modification of chromatin is involved in non-malignant pituitary neoplasia by causing abnormal expression of tumor suppressors and oncogenes.
Wenxiu Zhao, Xiaobin Jiang, Karrin Weisenthal, Jun Ma, Erin M. Botticelli, Yunli Zhou, E. Tessa Hedley-Whyte, Baiyao Wang, Brooke Swearingen, Roy J. Soberman, Anne Klibanski, Xun Zhang   +11 more
doaj   +1 more source

RGFP966 inactivation of the YAP pathway attenuates cardiac dysfunction induced by prolonged hypothermic preservation

Journal of Zhejiang University-SCIENCE B, 2020
Oxidative stress and apoptosis are the key factors that limit the hypothermic preservation time of donor hearts to within 4-6 h. The aim of this study was to investigate whether the histone deacetylase 3 (HDAC3) inhibitor RGFP966 could protect against cardiac injury induced by prolonged hypothermic preservation.
Xiao-he Zheng, Lin-lin Wang, Ming-zhi Zheng, Jin-jie Zhong, Ying-ying Chen, Yue-liang Shen   +5 more
openaire   +3 more sources