Histone deacetylase 3 regulates microglial function through histone deacetylation [PDF]
Epigenetics, 2023 As the primary innate immune cells of the brain, microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules.
Laura Meleady +6 more
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Regulation of pDC fate determination by histone deacetylase 3 [PDF]
eLife, 2023 Dendritic cells (DCs), the key antigen-presenting cells, are primary regulators of immune responses. Transcriptional regulation of DC development had been one of the major research interests in DC biology; however, the epigenetic regulatory mechanisms ...
Yijun Zhang +7 more
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Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation [PDF]
eLife, 2021 After antigenic activation, quiescent naive CD4+ T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides, amino acids, fatty acids, and sterols.
Drew Wilfahrt +9 more
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Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis [PDF]
Nature Communications, 2020 Alveolar macrophages are known to derive from embryonic precursors although the regulation of this process is poorly understood. Here the authors propose a key role for histone deacetylase 3 as an epigenetic regulator of lung alveolar macrophage ...
Yi Yao +11 more
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Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1 [PDF]
Protein & Cell, 2020 TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still remains to be uncovered.
Jie-lin Tang +14 more
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Histone deacetylase 3 inhibition alleviates type 2 diabetes mellitus-induced endothelial dysfunction via Nrf2 [PDF]
Cell Communication and Signaling, 2021 Background The mechanism underlying endothelial dysfunction leading to cardiovascular disease in type 2 diabetes mellitus (T2DM) remains unclear. Here, we show that inhibition of histone deacetylase 3 (HDAC3) reduced inflammation and oxidative stress by ...
Shuai Huang +10 more
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Efferocytosis and retinal clean-up: Role of histone deacetylase 3 in ischemic retinopathy [PDF]
Neural Regeneration ResearchAbdelrahman Y. Fouda, Esraa Shosha
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Frontiers in Pharmacology, 2023 Cell survival or death is critical for cardiac function. Myocardial pyroptosis, as a newly recognized programmed cell death, remains poorly understood in sepsis.
Ying Zhang +71 more
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Two assembly modes for SIN3 histone deacetylase complexes
Cell Discovery, 2023 The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play essential roles in regulating chromatin accessibility and gene expression. There are two major types of SIN3/HDAC complexes (named SIN3L and SIN3S) targeting different chromatin ...
Chengcheng Wang +5 more
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Integrative Regulation of Physiology by Histone Deacetylase 3 [PDF]
Nature Reviews Molecular Cell Biology, 2019 Mitchell Lazar, Matthew J Emmett
exaly +2 more sources