Histone deacetylase 3 regulates microglial function through histone deacetylation [PDF]
Epigenetics, 2023 As the primary innate immune cells of the brain, microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules.
Laura Meleady +6 more
doaj +4 more sources
Regulation of pDC fate determination by histone deacetylase 3 [PDF]
eLife, 2023 Dendritic cells (DCs), the key antigen-presenting cells, are primary regulators of immune responses. Transcriptional regulation of DC development had been one of the major research interests in DC biology; however, the epigenetic regulatory mechanisms ...
Yijun Zhang +7 more
doaj +4 more sources
Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis [PDF]
Nature Communications, 2020 Alveolar macrophages are known to derive from embryonic precursors although the regulation of this process is poorly understood. Here the authors propose a key role for histone deacetylase 3 as an epigenetic regulator of lung alveolar macrophage ...
Yi Yao +11 more
doaj +5 more sources
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation [PDF]
eLife, 2021 After antigenic activation, quiescent naive CD4+ T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides, amino acids, fatty acids, and sterols.
Drew Wilfahrt +9 more
doaj +2 more sources
Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1 [PDF]
Protein & Cell, 2020 TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still remains to be uncovered.
Jie-lin Tang +14 more
doaj +2 more sources
Histone deacetylase 3 inhibition alleviates type 2 diabetes mellitus-induced endothelial dysfunction via Nrf2 [PDF]
Cell Communication and Signaling, 2021 Background The mechanism underlying endothelial dysfunction leading to cardiovascular disease in type 2 diabetes mellitus (T2DM) remains unclear. Here, we show that inhibition of histone deacetylase 3 (HDAC3) reduced inflammation and oxidative stress by ...
Shuai Huang +10 more
doaj +2 more sources
Efferocytosis and retinal clean-up: Role of histone deacetylase 3 in ischemic retinopathy [PDF]
Neural Regeneration ResearchAbdelrahman Y. Fouda, Esraa Shosha
doaj +2 more sources
Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]
, 2020 Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
core +1 more source
Frontiers in Pharmacology, 2023 Cell survival or death is critical for cardiac function. Myocardial pyroptosis, as a newly recognized programmed cell death, remains poorly understood in sepsis.
Ying Zhang +71 more
doaj +1 more source
Two assembly modes for SIN3 histone deacetylase complexes
Cell Discovery, 2023 The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play essential roles in regulating chromatin accessibility and gene expression. There are two major types of SIN3/HDAC complexes (named SIN3L and SIN3S) targeting different chromatin ...
Chengcheng Wang +5 more
doaj +1 more source