Results 31 to 40 of about 18,392,427 (194)
Frontiers in Pharmacology, 2023 Cell survival or death is critical for cardiac function. Myocardial pyroptosis, as a newly recognized programmed cell death, remains poorly understood in sepsis.
Ying Zhang +71 more
doaj +1 more source
Histone deacetylase 3 indirectly modulates tubulin acetylation [PDF]
Biochemical Journal, 2015 Histone deacetylase 3 (HDAC3), a member of the Class I subfamily of HDACs, is found in both the nucleus and the cytoplasm. Its roles in the nucleus have been well characterized, but its cytoplasmic roles are still not elucidated fully. We found that blocking HDAC3 activity using MI192, a compound specific for HDAC3, modulated tubulin acetylation in the
Bacon, Travis J +7 more
openaire +5 more sources
Associations of histone deacetylase‐2 and histone deacetylase‐3 genes with schizophrenia in a
Asia-Pacific Psychiatry, 2012 AbstractIntroductionTo explore the association between histone deacetylase‐2 (HDAC2) and histone deacetylase‐3 (HDAC3) gene polymorphisms and schizophrenia.MethodsA total of 208 family trios consisting of fathers, mothers and affected offspring with schizophrenia were recruited as our subjects.
Hongzhi, Han +10 more
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Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]
, 2012 The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Julia Metzner +13 more
core +1 more source
Two assembly modes for SIN3 histone deacetylase complexes
Cell Discovery, 2023 The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play essential roles in regulating chromatin accessibility and gene expression. There are two major types of SIN3/HDAC complexes (named SIN3L and SIN3S) targeting different chromatin ...
Chengcheng Wang +5 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2017 The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer’s disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain.
Jingzhu Zhang +8 more
doaj +1 more source
Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke [PDF]
, 2009 Cigarette smoke (CS)-induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who
Adenuga, David +4 more
core +1 more source
Histone Deacetylase 3 Is Required for T Cell Maturation [PDF]
The Journal of Immunology, 2015 Abstract Recent thymic emigrants are newly generated T cells that need to undergo postthymic maturation to gain functional competency and enter the long-lived naive T cell pool. The mechanism of T cell maturation remains incompletely understood.
Fan-Chi, Hsu +6 more
openaire +2 more sources
New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]
, 2008 The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
P. D. Soldato +17 more
core +1 more source
MiR-376a and Histone Deacetylation 9 Form A Regulatory Circuitry in Hepatocellular Carcinoma
Cellular Physiology and Biochemistry, 2015 Background/Aims: Our previous study has demonstrated that down-regulation of miR-376a might contribute to the development of hepatocellular carcinoma (HCC), but the mechanism underlying this down-regulation remains obscure.
Yongxia Zheng +8 more
doaj +1 more source