Results 31 to 40 of about 88,424,874 (248)

Exploration of the Molecular Mechanism for Lipoprotein Lipase Expression Variations in SH-SY5Y Cells Exposed to Different Doses of Amyloid-Beta Protein

Frontiers in Aging Neuroscience, 2020
Progressive accumulation of amyloid-β (Aβ) plaques in the brain is a characteristic pathological change in Alzheimer’s disease (AD). We previously found the expression of lipoprotein lipase (LPL) was increased in SH-SY5Y cells exposed to low-dose Aβ and ...
Jingzhu Zhang, Yufan Liu, Sihui Wang, Ran Que, Weidong Zhao, Weidong Zhao, Li An   +6 more
doaj   +1 more source

Histone deacetylase inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1

Scientific Reports, 2023
Metastasis is a leading cause of mortality in patients with lung adenocarcinoma. Histone deacetylases have emerged as promising targets for anti-tumor drugs, with histone deacetylase inhibitors (HDACi) being an active area of research.
Dongmei Wang, Yixiao Yang, Yuxiang Cao, Meiyao Meng, Xiaobo Wang, Zhengxun Zhang, Wei Fu, Shichao Duan, Liming Tang   +8 more
doaj   +1 more source

Histone deacetylase 3 is required for iNKT cell development

Scientific Reports, 2017
NKT cells are a distinct subset that have developmental requirements that often differ from conventional T cells. Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction in the number of iNKT cells, particularly of NKT1 cells.
Puspa Thapa, Sinibaldo Romero Arocha, Ji Young Chung, Derek B. Sant’Angelo, Virginia Smith Shapiro   +4 more
doaj   +1 more source

HDAC2 (histone deacetylase 2) [PDF]

, 2010
Review on HDAC2 (histone deacetylase 2), with data on DNA, on the protein encoded, and where the gene is ...
Esteller, M, M Esteller, Ropero, S, S Ropero   +3 more
core   +1 more source

Mycobacterium tuberculosis Phosphoribosyltransferase Promotes Bacterial Survival in Macrophages by Inducing Histone Hypermethylation in Autophagy-Related Genes

Frontiers in Cellular and Infection Microbiology, 2021
Mycobacterium tuberculosis (Mtb) inhibits autophagy to promote its survival in host cells. However, the molecular mechanisms by which Mtb inhibits autophagy are poorly understood.
Srabasti Sengupta, Barsa Nayak, Michael Meuli, Peter Sander, Peter Sander, Snehasish Mishra, Avinash Sonawane   +6 more
doaj   +1 more source

The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma

, 2010
Recent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms.
Nolan, David Francis Luke
core   +2 more sources

Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation.

PLoS ONE, 2014
Regulator of calcineurin 1 (RCAN1; also referred as DSCR1 or MCIP1) is located in close proximity to a Down syndrome critical region of human chromosome 21.
Kyung Ah Han, Hye Seon Kang, Jee Won Lee, Lang Yoo, Eunju Im, Ahyoung Hong, Yun Ju Lee, Woo Hyun Shin, Kwang Chul Chung   +8 more
doaj   +1 more source

Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation

Haematologica, 2010
Background The clinical use of chromatin-modulating drugs, such as histone deacetylase inhibitors, for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last few years.
Marije Bartels, Christian R. Geest, Marc Bierings, Miranda Buitenhuis, Paul J. Coffer   +4 more
doaj   +1 more source

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

Cell Discovery, 2023
Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function.
Jialun Li, Lu Lu, Lingling Liu, Xuelian Ren, Jiwei Chen, Xingzhi Yin, Yanhui Xiao, Jiwen Li, Gang Wei, He Huang, Wei Wei, Jiemin Wong   +11 more
doaj   +1 more source

High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors

Frontiers in Oncology, 2022
Epigenetic modification of chromatin is involved in non-malignant pituitary neoplasia by causing abnormal expression of tumor suppressors and oncogenes.
Wenxiu Zhao, Xiaobin Jiang, Karrin Weisenthal, Jun Ma, Erin M. Botticelli, Yunli Zhou, E. Tessa Hedley-Whyte, Baiyao Wang, Brooke Swearingen, Roy J. Soberman, Anne Klibanski, Xun Zhang   +11 more
doaj   +1 more source