Results 51 to 60 of about 18,392,427 (194)

Snail regulation in fibroblast-like synoviocytes by a histone deacetylase or glycogen synthase kinase inhibitor affects cell proliferation and gene expression.

PLoS ONE, 2021
BackgroundSnail has been linked to the pathogenesis of rheumatoid arthritis (RA). We plan to investigate the regulation of Snail in response to TNF-α, histone acetylation, and glycogen synthase kinase-3 (GSK)-3 inhibition in fibroblast-like synoviocytes (
Po-Chuan Shen, Po-Chun Chang, Jeng-Long Hsieh   +2 more
doaj   +1 more source

The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo [PDF]

, 2008
Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical ...
Eva Juengel, Mickuckyte, Ausra, Hudak, Lukasz, Jones, Jon, Lukasz Hudak, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Roman A. Blaheta, Wedel, Steffen Alexander, Ausra Mickuckyte, Jonas, Dietger, Jon Jones, Steffen Wedel   +13 more
core   +1 more source

Histone deacetylase inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1

Scientific Reports, 2023
Metastasis is a leading cause of mortality in patients with lung adenocarcinoma. Histone deacetylases have emerged as promising targets for anti-tumor drugs, with histone deacetylase inhibitors (HDACi) being an active area of research.
Dongmei Wang, Yixiao Yang, Yuxiang Cao, Meiyao Meng, Xiaobo Wang, Zhengxun Zhang, Wei Fu, Shichao Duan, Liming Tang   +8 more
doaj   +1 more source

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model [PDF]

, 2011
NOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of Disease. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Ezzatizadeh, V, Rusche, James R., Steve Jones, James R. Rusche, Gottesfeld, Joel M., Jones, S, Sandi, C, Barnes, Glenn, Joel M. Gottesfeld, Pook, MA, Pinto, RM, Al-Mahdawi, Sahar, Chiranjeevi Sandi, Sandi, Chiranjeevi, Barnes, G, Mark A. Pook, Pinto, Ricardo Mouro, Al-Mahdawi, S, Jones, Steve, Pook, Mark A., Vahid Ezzatizadeh, Ezzatizadeh, Vahid, Sahar Al-Mahdawi, Rusche, JR, Ricardo Mouro Pinto, Gottesfeld, JM, Glenn Barnes   +26 more
core   +1 more source

Exploration of the Molecular Mechanism for Lipoprotein Lipase Expression Variations in SH-SY5Y Cells Exposed to Different Doses of Amyloid-Beta Protein

Frontiers in Aging Neuroscience, 2020
Progressive accumulation of amyloid-β (Aβ) plaques in the brain is a characteristic pathological change in Alzheimer’s disease (AD). We previously found the expression of lipoprotein lipase (LPL) was increased in SH-SY5Y cells exposed to low-dose Aβ and ...
Jingzhu Zhang, Yufan Liu, Sihui Wang, Ran Que, Weidong Zhao, Weidong Zhao, Li An   +6 more
doaj   +1 more source

Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma [PDF]

Experimental Hematology & Oncology, 2021
Abstract Background Multiple myeloma (MM) is a type of hematological malignancy affecting the functions of plasma cells. The treatment of MM patients has changed dramatically with the use of new agents. However, unfortunately, it is still incurable.
Seiichi Okabe, Yuko Tanaka, Akihiko Gotoh   +2 more
openaire   +3 more sources

Regulation of Histone Deacetylase 4 by Binding of 14-3-3 Proteins [PDF]

Molecular and Cellular Biology, 2000
Histone (de)acetylation is important for the regulation of fundamental biological processes such as gene expression and DNA recombination. Distinct classes of histone deacetylases (HDACs) have been identified, but how they are regulated in vivo remains largely unexplored.
A H, Wang, M J, Kruhlak, J, Wu, N R, Bertos, M, Vezmar, B I, Posner, D P, Bazett-Jones, X J, Yang   +7 more
openaire   +2 more sources

Mycobacterium tuberculosis Phosphoribosyltransferase Promotes Bacterial Survival in Macrophages by Inducing Histone Hypermethylation in Autophagy-Related Genes

Frontiers in Cellular and Infection Microbiology, 2021
Mycobacterium tuberculosis (Mtb) inhibits autophagy to promote its survival in host cells. However, the molecular mechanisms by which Mtb inhibits autophagy are poorly understood.
Srabasti Sengupta, Barsa Nayak, Michael Meuli, Peter Sander, Peter Sander, Snehasish Mishra, Avinash Sonawane   +6 more
doaj   +1 more source

EVALUATION OF HISTONE DEACETYLASE INHIBITOR EFFECTS ON THYROID CANCER [PDF]

, 2009
Histone deacetylases (HDACs) play a crucial role in the proper regulation of cellular functions through their connection with chromatin and transcriptional regulation.
Borbone, Eleonora
core   +1 more source

Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation.

PLoS ONE, 2014
Regulator of calcineurin 1 (RCAN1; also referred as DSCR1 or MCIP1) is located in close proximity to a Down syndrome critical region of human chromosome 21.
Kyung Ah Han, Hye Seon Kang, Jee Won Lee, Lang Yoo, Eunju Im, Ahyoung Hong, Yun Ju Lee, Woo Hyun Shin, Kwang Chul Chung   +8 more
doaj   +1 more source