Results 51 to 60 of about 157,390 (295)

Histone Deacetylase 3 Is Necessary for Proper Brain Development [PDF]

Journal of Biological Chemistry, 2014
The functional role of histone deacetylase 3 (HDAC3) in the developing brain has yet to be elucidated. We show that mice lacking HDAC3 in neurons and glia of the central nervous system, Nes-Cre/HDAC3 conditional KO mice, show major abnormalities in the cytoarchitecture of the neocortex and cerebellum and die within 24 h of birth.
Jordan, Norwood, Jade M, Franklin, Dharmendra, Sharma, Santosh R, D'Mello   +3 more
openaire   +2 more sources

High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors

Frontiers in Oncology, 2022
Epigenetic modification of chromatin is involved in non-malignant pituitary neoplasia by causing abnormal expression of tumor suppressors and oncogenes.
Wenxiu Zhao, Xiaobin Jiang, Karrin Weisenthal, Jun Ma, Erin M. Botticelli, Yunli Zhou, E. Tessa Hedley-Whyte, Baiyao Wang, Brooke Swearingen, Roy J. Soberman, Anne Klibanski, Xun Zhang   +11 more
doaj   +1 more source

Histone Epigenetic Signatures in Embryonic Limb Interdigital Cells Fated to Die

Cells, 2021
During limb formation in vertebrates with free digits, the interdigital mesoderm is eliminated by a massive degeneration process that involves apoptosis and cell senescence. The degradation process is preceded by intense DNA damage in zones located close
Cristina Sanchez-Fernandez, Carlos I. Lorda-Diez, Cristina Duarte-Olivenza, Juan M. Hurle, Juan A. Montero   +4 more
doaj   +1 more source

Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells [PDF]

, 2018
Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands.
Agnusdei, Valentina, Amadori, Alberto, Ciminale, Vincenzo, Ciribilli, Yari, Fossati, Gianluca, Ghisi, Margherita, Indraccolo, Stefano, Minuzzo, Sonia, Pezz\ue8, Laura, Pilotto, Giorgia, Pinazza, Marica, Venturoli, Carolina   +11 more
core   +3 more sources

Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation

Haematologica, 2010
Background The clinical use of chromatin-modulating drugs, such as histone deacetylase inhibitors, for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last few years.
Marije Bartels, Christian R. Geest, Marc Bierings, Miranda Buitenhuis, Paul J. Coffer   +4 more
doaj   +1 more source

Histone deacetylase 3 represses HTLV-1 tax transcription

Oncology Reports, 2006
We examined the epigenetic mechanisms involved in human T-cell lymphotropic virus type 1 (HTLV-1) Tax expression. Blockade of histone deacetylation with trichostatin A (TSA) resulted in Tax upregulation. Using a chromatin immunoprecipitation (ChIP) assay, we verified local histone hyperacetylation at the HTLV-1 LTR in response to TSA.
Raul, Villanueva, Antonio H, Iglesias, Sandra, Camelo, Luis C, Sanin, Steven G, Gray, Fernando, Dangond   +5 more
openaire   +3 more sources

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal [PDF]

, 2018
Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in a variety of conditions including peritoneal dialysis (PD), post-surgery adhesions and peritoneal metastases.
Battistelli, Cecilia, Bordoni, Veronica, DE TURRIS, Valeria, Domenici, Alessandro, Mai, Antonello, Manzione, Andrea, Mene', Paolo, Moioli, Alessandra, Noce, Valeria, Palladino, Marco, Rossi, Lucia, Strippoli, Raffaele, Tripodi, Marco, Valente, Sergio, Zwergel, Clemens   +14 more
core   +1 more source

Histone deacetylase inhibitors

Journal of Education, Health and Sport, 2020
The human genome is contained in chromatin, which is a complex macromolecular complex. It is made of DNA, histones and non-histone proteins. The structure of chromatin and the process of its rearrangement regulate the process of transcription, and hence ...
Marzena Baran, Paulina Anna Miziak, Katarzyna Bonio   +2 more
doaj   +1 more source

Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]

, 2015
In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia, Saccone, Valentina, Sandona', Martina   +2 more
core   +4 more sources

Histone deacetylase 3 gene in hematopoietic stem cells promotes mouse lymphogenesis

Di-san junyi daxue xuebao, 2019
Objective To investigate the role of histone deacetylase 3 gene (Hdac3) in hematopoiesis by developing a conditional Hdac3 knockout mice. Methods We crossed the Hdac3floxp/floxp mice with Mx1-Cre mice to generate Hdac3fl/flMx1-Cre mice, and then ...
LYU Wenqiong, SHU Yi, YANG Bijie, ZHANG Hang   +3 more
doaj   +1 more source