Results 71 to 80 of about 18,392,427 (194)

Inhibition of Plk1 and Cyclin B1 expression results in panobinostat-induced G(2) delay and mitotic defects [PDF]

, 2013
Work by JP is funded by a Royal Society University Research Fellowship award. Experiments carried out by MBP were supported by the Department of Pathology, Albert Einstein College of Medicine / Montefiore Medical Center.The development of clinically ...
Parish, Joanna, Kawachi, Nicole, Loudig, Olivier, Feeney, Katherine, Antkowiak, Maciej, Prystowsky, Michael, Wasson, Christopher, Parish, Joanna; id_orcid, Willmott, Michelle, Montagna, Cristina   +9 more
core   +1 more source

The histone deacetylase-3 complex contains nuclear receptor corepressors [PDF]

Proceedings of the National Academy of Sciences, 2000
Acetylation and deacetylation of nucleosomal histones have profound effects on gene transcription in all eukaryotes. In humans, three highly homologous class I and four class II histone deacetylase (HDAC) enzymes have been identified to date.
Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E   +7 more
openaire   +3 more sources

Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus

Nature Communications
Cell-cell junctions, and specifically desmosomes, are crucial for robust intercellular adhesion. Desmosomal function is compromised in the autoimmune blistering skin disease pemphigus vulgaris.
Henriette Franz, Maitreyi Rathod, Aude Zimmermann, Chiara Stüdle, Vivien Beyersdorfer, Karen Leal-Fischer, Pauline Hanns, Tomás Cunha, Dario Didona, Michael Hertl, Marion Scheibe, Falk Butter, Enno Schmidt, Volker Spindler   +13 more
doaj   +1 more source

Histone Deacetylase 3 Is Required for Efficient T Cell Development [PDF]

Molecular and Cellular Biology, 2015
Hdac3 is a key target for Hdac inhibitors that are efficacious in cutaneous T cell lymphoma. Moreover, the regulation of chromatin structure is critical as thymocytes transition from an immature cell with open chromatin to a mature T cell with tightly condensed chromatin.
Kristy R, Stengel, Yue, Zhao, Nicholas J, Klus, Jonathan F, Kaiser, Laura E, Gordy, Sebastian, Joyce, Scott W, Hiebert, Alyssa R, Summers   +7 more
openaire   +2 more sources

H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation [PDF]

, 2011
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied.
Richard J. Festenstein, Bonneil, Eric, Guillemette Benoit, Festenstein Richard J., Armstrong Harry, Festenstein, Richard J., Harry Armstrong, Imhof Axel, Armstrong, Harry, Richard J Festenstein, Drogaris, Paul, Axel Imhof, Verreault Alain, Kyoko Hiragami-Hamada, Drogaris Paul, Verreault, Alain, Benoit Guillemette, Thibault Pierre, Pierre Thibault, Lin Hsiu-Hsu Sophia, Hiragami-Hamada, Kyoko, Alain Verreault, Imhof, Axel, Paul Drogaris, Hsiu-Hsu Sophia Lin, Bonneil Éric, Eric Bonneil, Festenstein, Richard J, Hiragami-Hamada Kyoko, Guillemette, Benoit, Lin, Hsiu-Hsu Sophia, Thibault, Pierre   +31 more
core   +1 more source

The histone H3 lysine 36 methyltransferase HypB facilitates embryonic stem cell differentiation [PDF]

, 2007
Histone H3 lysine 36 (H3K36) methylation was identified as a conserved modification from yeast to human. In yeast, biochemical characterization of the SET2 protein and genome wide mapping of H3K36me2 and K36me3 indicate that H3K36 methylation functions ...
Wang, Tianke
core   +1 more source

The Histone Deacetylase Inhibitory Potential of Chicken Egg Yolk Fat and Their Fatty Acid Composition

Scientifica, 2023
Histone deacetylation is a key biochemical event associated with transcriptional regulation. Histone deacetylases (HDACs) mediate the deacetylation of histones. Fatty acids have been reported to function as histone deacetylase inhibitors (HDACi).
Meran Keshawa Ediriweera
doaj   +1 more source

Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src [PDF]

Oncogene, 2006
Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members remain in the nucleus.
M S, Longworth, L A, Laimins
openaire   +2 more sources

The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma

, 2010
Recent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms.
Nolan, David Francis Luke
core   +1 more source

Essential angiosperm-specific subunits of HDA19 histone deacetylase complexes in Arabidopsis

The EMBO Journal
Although the Arabidopsis thaliana RPD3-type histone deacetylase HDA19 and its close homolog HDA6 participate in SIN3-type histone deacetylase complexes, they display distinct biological roles, with the reason for these differences being poorly understood.
Na Liu, Jia-Xin Li, Dan-Yang Yuan, Yin-Na Su, Pei Zhang, Qi Wang, Xiao-Min Su, Lin Li, Haitao Li, She Chen, Xin-Jian He   +10 more
doaj   +1 more source