Results 81 to 90 of about 18,392,427 (194)

Cardiac HDAC3 Disruption Contributes to HDAC Inhibitor-Induced QT Prolongation

Cells
Histone deacetylase (HDAC) inhibitors are approved for cancer treatment and are being investigated for a wide range of other diseases. Despite their therapeutic promise, clinical studies have reported cardiac side effects, particularly electrocardiogram (
Jiao Lu, Christopher Ward, Sichong Qian, Lilei Zhang, Jiang Chang, Zheng Sun   +5 more
doaj   +1 more source

Tubastatin A Improves Post‐Resuscitation Myocardial Dysfunction by Inhibiting NLRP3‐Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Myocardial dysfunction is the leading cause of early death following successful cardiopulmonary resuscitation (CPR) in people with cardiac arrest (CA), which is potentially driven by cell pyroptosis mediated by NOD‐like receptor pyrin domain 3
Jiefeng Xu, Xue Zhao, Xiangkang Jiang, Lu He, Xinjie Wu, Jiangang Wang, Qijiang Chen, Yulin Li, Mao Zhang   +8 more
doaj   +1 more source

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function [PDF]

, 2002
This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Wang, Jian, Pestell, RG0, Fuqua, Suzanne A W, Wang, Chenguang, Yeung, YG, Hopp, Torsten, Jaffray, E, Chang, Chawnshang, Fu, Maofu, Sakamaki, Toshiyuki, Janne, OA, Zhang, Xueping, Hay, Ronald Thomas, Palvimo, Jorma J   +13 more
core   +2 more sources

Genetic and Chemical Screenings Identify HDAC3 as a Key Regulator in Hepatic Differentiation of Human Pluripotent Stem Cells

Stem Cell Reports, 2018
Summary: Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells (hPSCs) offer a promising cell resource for disease modeling and transplantation.
Shuang Li, Mushan Li, Xiaojian Liu, Yuanyuan Yang, Yuda Wei, Yanhao Chen, Yan Qiu, Tingting Zhou, Zhuanghui Feng, Danjun Ma, Jing Fang, Hao Ying, Hui Wang, Kiran Musunuru, Zhen Shao, Yongxu Zhao, Qiurong Ding   +16 more
doaj   +1 more source

Histone deacetylase 3 binds to and regulates the GCMa transcription factor [PDF]

Nucleic Acids Research, 2006
Human GCMa transcription factor regulates expression of syncytin, a placental fusogenic protein mediating trophoblastic fusion. Recently, we have demonstrated that CBP-mediated GCMa acetylation underlies the activated cAMP/PKA signaling pathway that stimulates trophoblastic fusion.
Chuang, Hsiao-Ching, Chang, Ching-Wen, Chang, Geen-Dong, Yao, Tso-Pang, Chen, Hungwen   +4 more
openaire   +2 more sources

Epigenetic dynamics of Helicobacter pylori-induced COX-2 activation [PDF]

, 2009
Background and Aims: Cyclooxigenase (COX)-2 is over expressed in gastrointestinal neoplasia and Helicobacter pylori (H. pylori) infection is casually linked to gastric cancer. We undertook this study to investigate the mechanism mediating H.
Peluso, Silvia
core   +1 more source

Acetylation site specificities of lysine deacetylase inhibitors in human cells [PDF]

, 2015
This work was supported by the Hallas Møller Investigator grant from the Novo Nordisk Foundation to C.C. S.A.W. and P.B. were supported by individual postdoctoral grants from the Danish Research Council (FSS: 10-085134, FSS: 12-12610). C.C.
Sebastian A Wagner, Jensen, Lars J., Jensen, Lars J, Chunaram Choudhary, Qi, Yun, Sonia Lain, Wagner, Sebastian A, Weinert, Brian T., James E Bradner, McCarthy, Anna R, Mann, Matthias, Yasuyuki Miyake, Westwood, Nicholas J, Schölz, Christian, Wagner, Sebastian A., Choudhary, Chunaram, Choudhary, Chuna Ram, Matthias, Patrick, Bradner, James E, Anna R McCarthy, Werner Streicher, Weinert, Brian Tate, Lain, Sonia, Bradner, James E., Matthias Mann, Nicholas J Westwood, Lars J Jensen, Jürgen Cox, Westwood, Nicholas James, Brian T Weinert, Cox, Jürgen, Christian Schölz, Streicher, Werner, McCarthy, Anna Rose, Lain, Sonya, Beli, Petra, Qi, Jun, Petra Beli, Jun Qi, Miyake, Yasuyuki, Patrick Matthias   +40 more
core   +1 more source

Transcriptional gene silencing mutants in "Arabidopsis thaliana" and their impact on nuclear architecture and heterochromatin organization [PDF]

, 2004
The epigenetic regulation of gene expression is defined by covalent modifications of DNA and histone tails as well as by chromatin structure and nuclear architecture.
Valeska Probst, Aline
core   +1 more source

Habits Are Negatively Regulated by Histone Deacetylase 3 in the Dorsal Striatum [PDF]

Biological Psychiatry, 2018
Optimal behavior and decision making result from a balance of control between two strategies, one cognitive/goal-directed and one habitual. These systems are known to rely on the anatomically distinct dorsomedial and dorsolateral striatum, respectively.
Malvaez, Melissa, Greenfield, Venuz, Matheos, Dina, Angelillis, Nicolas, Murphy, Michael, Kennedy, Pamela, Wassum, Kate, Wood, Marcelo   +7 more
openaire   +5 more sources

Histone deacetylase inhibitors in treatment of cancer

, 2022
New studies have shown that histone deacetylase inhibitors can help as a novel antitumor drugs in cotherapy with conventional radiochemotherapy especially in CTCL. Several studies and clinical trials have used specific and non specific HDACi.
Metwaly, Laila Tarek Abbas
core