Results 101 to 110 of about 18,392,427 (194)

Phosphatidylinositol 3‐Kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPlatelet‐derived growth factor BB, a potent mitogen of pulmonary artery smooth muscle cells (PASMCs), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension.
Yanjiao Li, Li Li, Zhengjiang Qian, Boya Lin, Jidong Chen, Yixuan Luo, Junle Qu, J. Usha Raj, Deming Gou   +8 more
doaj   +1 more source

Nitric oxide induces chromatin remodelling in the developing central nervous system [PDF]

, 2009
The development of the nervous system is a complex task that involves precise connections between billions of neurons. This is achieved, at least in part, by the overproduction of neurons and the survival of a select few that compete for limited ...
Nott, A, Nott, A.
core  

Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents

, 2013
Katherine Ververis,1 Alison Hiong,1 Tom C Karagiannis,1,* Paul V Licciardi2,*1Epigenomic Medicine, Alfred Medical Research and Education Precinct, 2Allergy and Immune Disorders, Murdoch Childrens Research Institute, Melbourne, VIC, Australia*These ...
Ververis, K, Hiong A, Ververis K, Karagiannis, TC, Licciardi, PV, Karagiannis TC, Hiong, A, Licciardi PV   +7 more
core   +1 more source

Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]

, 2007
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea, Prokhortchouk, Anna, Adie, Karen, Hendrich, Brian, Barr, Helen, Tsai, Hsin-Hao, Berger, Jennifer, Bird, Adrian; id_orcid   +7 more
core   +1 more source

SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53 [PDF]

, 2010
Background The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-
Ahmed, Shafiq U., Milner, J, Jack Ford, Li, Han, Li, H, Ford, J, Serrano, M, Lynch, CJ, Milner, Jo, Ford Jack, Han Li, Blagosklonny, Mikhail V., Ahmed, Shafiq, Allison, SJ, Jo Milner, Simon J Allison, Simon J. Allison, Manuel Serrano, Warnock Lorna J., Warnock, LJ, Lorna J Warnock, Zahid H. Shah, Shafiq U Ahmed, Lorna J. Warnock, Serrano, Manuel, Shah, ZH, Lynch Cian J., Shah, Zahid H., Allison, Simon J., Shah Zahid H., Shafiq U. Ahmed, Serrano Manuel, Milner Jo, Cian J. Lynch, Lynch, Cian J., Li Han, Ahmed Shafiq U., Allison Simon J., Ford, Jack, Warnock, Lorna J., Cian J Lynch, Zahid H Shah   +41 more
core   +1 more source

The CBX7 protein, whose expression is decreased in human carcinomas, positively regulates E-cadherin expression by interacting with the HDAC2 protein. [PDF]

, 2009
CBX7, chromobox homolog 7, is a chromobox family protein encoding a novel Polycomb protein, component of the Polycomb repressive complex 1 (PRC1). The Polycomb group (PcG) proteins are epigenetic transcriptional repressors involved in the control of ...
Bianco, Mimma
core   +1 more source

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity

Cell Reports, 2017
Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6).
Rafael M. Ioris, Mirco Galié, Giorgio Ramadori, Jason G. Anderson, Anne Charollais, Georgia Konstantinidou, Xavier Brenachot, Ebru Aras, Algera Goga, Nicholas Ceglia, Carlos Sebastián, Denis Martinvalet, Raul Mostoslavsky, Pierre Baldi, Roberto Coppari   +14 more
doaj   +1 more source

Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]

, 2013
Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
core   +1 more source

Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. [PDF]

, 2010
Histone modifications are critical in regulating gene expression, cell cycle, cell proliferation, and development. Relatively few studies have investigated whether Helicobacter pylori, the major cause of human gastric diseases, affects histone ...
Haas, Rainer, Rainer Haas, Grant, Patrick, Kaparakis-Liaskos, Maria, Hass, Rainer, Sheila E Crowe, Patrick A. Grant, Crowe, Sheila E., Crowe Sheila E., Liechti, George, Ferrero, Richard L., Richard L. Ferrero, D. Scott Merrell, Kaparakis-Liaskos Maria, Merrell, D. Scott, Wolfgang Fischer, Fischer, Wolfgang, Liechti George, Ferrero Richard L., Ding, Song-Ze, Goldberg Joanna B., Song-Ze Ding, Ding Song-Ze, George Liechti, Patrick A Grant, Crowe, Sheila, Goldberg, Joanna, Fischer Wolfgang, Joanna B Goldberg, D Scott Merrell, Hatakeyama, Masanori, Ferrero, Richard, Merrell D. Scott, Haas Rainer, Joanna B. Goldberg, Goldberg, Joanna B., Richard L Ferrero, Sheila E. Crowe, Masanori Hatakeyama, Grant Patrick A., Hatakeyama Masanori, Grant, Patrick A., Liaskos, Maria, Maria Kaparakis-Liaskos   +43 more
core   +1 more source

NoRC, a novel chromatin remodeling complex involved in ribosomal RNA gene silencing [PDF]

, 2004
Regulation of gene expression takes place in the nucleus in a highly structured and condensed nucleoprotein environment, called chromatin (Felsenfeld and Groudine, 2003; Khorasanizadeh, 2004; Vaquero et al., 2003).
Strohner, Ralf
core   +1 more source