Results 111 to 120 of about 18,392,427 (194)

Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells

iScience, 2019
Summary: We report that cerebrum-specific inactivation of the histone deacetylase 3 (HDAC3) gene causes striking developmental defects in the neocortex, hippocampus, and corpus callosum; post-weaning lethality; and abnormal behaviors, including ...
Lin Li, Jianliang Jin, Xiang-Jiao Yang
doaj   +1 more source

The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer [PDF]

, 2015
This study was supported by financial support from the University of Edinburgh/China Scholarship Council joint Scholarship Scheme. We are also grateful to support from the Scottish Funding Council.Chromatin undergoes structural changes in response to ...
Mullen, Peter, Um, In Hwa, Huang, Rui, Langdon, Simon, Tse, Matthew, Harrison, David, Harrison, David James, Langdon, Simon P., Faratian, Dana   +8 more
core   +1 more source

Histone Deacetylase 3 Is Involved in Maintaining Queen Hallmarks of a Termite

Molecular Ecology
ABSTRACTThe role of epigenetics in regulating caste polyphenism in social insects has been debated. Here, we tested the importance of histone de/acetylation processes for the maintenance of queen hallmarks like a high fecundity and a long lifespan.
Louis Allan Okwaro, Judith Korb
openaire   +3 more sources

Histone deacetylase 3 represses HTLV-1 tax transcription

Oncology Reports, 2006
We examined the epigenetic mechanisms involved in human T-cell lymphotropic virus type 1 (HTLV-1) Tax expression. Blockade of histone deacetylation with trichostatin A (TSA) resulted in Tax upregulation. Using a chromatin immunoprecipitation (ChIP) assay, we verified local histone hyperacetylation at the HTLV-1 LTR in response to TSA.
Raul, Villanueva, Antonio H, Iglesias, Sandra, Camelo, Luis C, Sanin, Steven G, Gray, Fernando, Dangond   +5 more
openaire   +3 more sources

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression [PDF]

, 2012
Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to induce histone hyperacetylation and deregulate gene transcription, but it is not known whether the inhibition of HDACs plays any part in the normal physiological
Sproul, Duncan, Mackay, Logan, Culley, Jayne, Ramsahoye, Bernard H, Langridge-Smith, Pat, Gilbert, Nick, Harrison, David J, Latham, Tom, Hayward, Larry, Ramsahoye, Bernard H., Karim, Muhammed, Harrison, David J.   +11 more
core   +1 more source

Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression

Frontiers in Aging Neuroscience, 2017
Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. The accumulation of Aβ in the brain is thought to play a causative role in the development of cognitive dysfunction in Alzheimer's disease.
Li An, Jingzhu Zhang, Rui Zhang, Rui Zhang, Zhipeng Zhan, Xinhui Li, Fuyuan Zhou, Aiping Xing, Congmin Jiang, Yanqiu Chen   +9 more
doaj   +1 more source

Citronellol inhibits the activity of AtSRT1 to increase IAA content and signal transduction, promoting the growth of A. thaliana

Chemical and Biological Technologies in Agriculture
Histone acetylation is a key epigenetic modification involved in plant development. Although histone deacetylase inhibitors (HDACi) are commonly studied in human diseases, their role in regulating histone deacetylation in plants remains unclear.
Jin-Rui Wen, Hong-Yan Nie, Hong-Xin Liao, Fu-Rong Xu, Xiao-Yun Liu, Xian Dong   +5 more
doaj   +1 more source

Histone Deacetylase Inhibitors: Novel advances in Cancer Therapy

, 2018
Nowadays, it became evident that the onset of cancer and its progression may not occur only due to genetic mutations but also because of changes in the patterns of epigenetic modifications.
Quach, Khong Tri
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Use of Histone Deacetylase Inhibitors (HDI): Novel Advances in Cancer Treatment

, 2020
Histone deacetylase inhibitors are powerful epigenetic modifiers, altering gene expression and on a larger aspect, the fate of individual cells. The Food and Drugs Administration has approved the use of four new HDIs, bringing about a revolutionary dawn ...
Savani, Vandan
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Untersuchungen zur Regulation der 5-Lipoxygenase-Gen-Expression durch DNA-Methylierung und Histon-Deacetylierung/Acetylierung [PDF]

, 2007
5-LO is the key enzyme in the biosynthesis of proinflammatory leukotrienes, converting arachidonic acid to 5-HPETE, and in a second step 5-HPETE to leukotriene A4. Although the 5-LO promoter possesses characteristics of so called housekeeping genes, such
Schnur, Nicole
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