Results 91 to 100 of about 18,392,427 (194)

Histone deacetylase 3 as a novel therapeutic target in multiple myeloma [PDF]

Leukemia, 2013
Histone deacetylases (HDACs) represent novel molecular targets for the treatment of various types of cancers, including multiple myeloma (MM). Many HDAC inhibitors have already shown remarkable antitumor activities in the preclinical setting; however, their clinical utility is limited because of unfavorable toxicities associated with their broad range ...
J, Minami, R, Suzuki, R, Mazitschek, G, Gorgun, B, Ghosh, D, Cirstea, Y, Hu, N, Mimura, H, Ohguchi, F, Cottini, J, Jakubikova, N C, Munshi, S J, Haggarty, P G, Richardson, T, Hideshima, K C, Anderson   +15 more
openaire   +2 more sources

Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist

Cell Reports, 2019
Summary: Vaccinia virus (VACV) has numerous immune evasion strategies, including multiple mechanisms of inhibition of interferon regulatory factor 3 (IRF-3), nuclear factor κB (NF-κB), and type I interferon (IFN) signaling.
Lior Soday, Yongxu Lu, Jonas D. Albarnaz, Colin T.R. Davies, Robin Antrobus, Geoffrey L. Smith, Michael P. Weekes   +6 more
doaj   +1 more source

The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma [PDF]

, 2008
We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortezomib in Hodgkin lymphoma (L428) and non-Hodgkin's ...
Kevin David, Lauren Mauro, Savita Bhalla, Sheila Prachand, Andrew Evens, Leo Gordon, Joseph Buggy, Sriram Balasubramanian, Mint Sirisawad, Richard Miller   +9 more
core  

Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation

Cell Reports, 2017
Mucosal tissues are constantly in direct contact with diverse beneficial and pathogenic microbes, highlighting the need for orchestrating complex microbial signals to sustain effective host defense.
Nazanin Navabi, Jordan Whitt, Shu-en Wu, Vivienne Woo, Jessica Moncivaiz, Michael B. Jordan, Bruce A. Vallance, Sing Sing Way, Theresa Alenghat   +8 more
doaj   +1 more source

Functional Characterization of Histone Deacetylase 2 and Histone Deacetylase 3 in Candida albicans

, 2019
C. a lbica ns is an opportunistic fungal pathogen which causes infections in humans and contributes significantly to world mortality rates. The phenotypic plasticity of this yeast supports its virulence and different morphologies are triggered by specific environmental cues including temperature, nutritional deprivation and pH.
openaire   +1 more source

HISTONE DEACETYLASE INHIBITORS FOR CANCER TREATMENT DRUG DEVELOPMENT IN CONTEMPORARY ONCOLOGY

, 2014
inhibitors as novel anticancer therapeutics D.R. Walkinshaw MSc * and X.J. Yang PhD* Histone deacetylase inhibitors represent a promising new class of compounds for the treatment of cancer.
Key Words, Histone Deacetylase
core  

Enhanced efficacy of 5-fluorouracil in combination with a dual histone deacetylase and phosphatidylinositide 3-kinase inhibitor (CUDC-907) in colorectal cancer cells

The Saudi Journal of Gastroenterology, 2017
Background/Aims: 5-Fluorouracil (5-FU) is widely used in the treatment of patients with colorectal cancer (CRC). However, the efficacy of 5-FU as a single agent is limited, with multiple undesired side effects. Therefore, the aim of the current study was
Rimi Hamam, Dalia Ali, Radhakrishnan Vishnubalaji, Zaid F Alsaaran, Elna Paul Chalisserry, Musaad Alfayez, Abdullah Aldahmash, Nehad M Alajez   +7 more
doaj   +1 more source

HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity

Nature Communications
Anthracycline-induced cardiotoxicity remains a major limitation of cancer therapy, and effective preventive strategies are lacking. Topoisomerase IIb has been implicated as a central driver of this toxicity, suggesting that epigenetic regulators may ...
Benay Eksi, Daniel Finke, Synje Michel, Jannek Brauer, Markus B. Heckmann, Mohsen Valadan, Leonard M. Schanze, Vighnesh Sunder, Kevin Steimel, Jürgen Burhenne, Timon Seeger, Hugo A. Katus, Norbert Frey, Johannes Backs, Lorenz H. Lehmann   +14 more
doaj   +1 more source

Inhibition of HDAC3 Promotes Psoriasis Development in Mice Through Regulating Th17

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveTo investigate the influence of histone deacetylase 3 (HDAC3) on the occurrence, development of psoriasis-like inflammation in mice, and the relative immune mechanisms.MethodsHealthy C57BL/6 mice aged 6-8 weeks were selected and randomly divided
XU Fan, ZHANF Xin-Rui, XIA Yang-Chen, LI Wen-Ting, CHEN Hao, QIN An-Qi, ZHANG Ai-Hong, ZHU Yi-Ran, TIAN Feng, ZHENG Quan-Hui   +9 more
doaj   +1 more source

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease [PDF]

, 2008
RATIONALE:Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein ...
Rajendrasozhan, Saravanan, Kinnula, Vuokko L, Rahman, Irfan, Yang, Se-Ran   +3 more
core   +1 more source