Results 61 to 70 of about 18,392,427 (194)

Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation

Haematologica, 2010
Background The clinical use of chromatin-modulating drugs, such as histone deacetylase inhibitors, for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last few years.
Marije Bartels, Christian R. Geest, Marc Bierings, Miranda Buitenhuis, Paul J. Coffer   +4 more
doaj   +1 more source

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

Cell Discovery, 2023
Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function.
Jialun Li, Lu Lu, Lingling Liu, Xuelian Ren, Jiwei Chen, Xingzhi Yin, Yanhui Xiao, Jiwen Li, Gang Wei, He Huang, Wei Wei, Jiemin Wong   +11 more
doaj   +1 more source

High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors

Frontiers in Oncology, 2022
Epigenetic modification of chromatin is involved in non-malignant pituitary neoplasia by causing abnormal expression of tumor suppressors and oncogenes.
Wenxiu Zhao, Xiaobin Jiang, Karrin Weisenthal, Jun Ma, Erin M. Botticelli, Yunli Zhou, E. Tessa Hedley-Whyte, Baiyao Wang, Brooke Swearingen, Roy J. Soberman, Anne Klibanski, Xun Zhang   +11 more
doaj   +1 more source

Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer [PDF]

, 2016
Previous studies have associated the overexpression of histone deacetylase 2 (HDAC2) and the presence of TP53 mutations with the progression to advanced stage drug resistant colorectal cancer (CRC).
El-Bahrawy, M., Alzoubi, S, Brody, L., Silver, A, Bell, J, Hajji, N, Mercado, N., Mahul-Mellier, AL, Silver, A., Boobis, A., Mahul-Mellier, A.L., Bell, JD, Hajji, N., Mahul-Mellier, A-L, Bell, J.D., Rahman, S., Rahman, S, Boobis, A, Brody, L, Ito, K., Mahul Mellier, AL, Ito, K, Mercado, N, Alzoubi, S., El-Bahrawy, M   +24 more
core   +1 more source

Histone Epigenetic Signatures in Embryonic Limb Interdigital Cells Fated to Die

Cells, 2021
During limb formation in vertebrates with free digits, the interdigital mesoderm is eliminated by a massive degeneration process that involves apoptosis and cell senescence. The degradation process is preceded by intense DNA damage in zones located close
Cristina Sanchez-Fernandez, Carlos I. Lorda-Diez, Cristina Duarte-Olivenza, Juan M. Hurle, Juan A. Montero   +4 more
doaj   +1 more source

Relationship Between Histone Deacetylase 3 (HDAC3) and Breast Cancer [PDF]

Medical Science Monitor, 2018
BACKGROUND The modification of histone acetylation and deacetylation is the most important mechanism of chromatin remodeling. These modifications are a subset of epigenetic alterations which affect tumorigenesis and progression through changes in gene expression and cell growth.
Cui, Zhuhong, Xie, Mingjun, Wu, Zhenru, Shi, Yujun   +3 more
openaire   +2 more sources

Endocardial HDAC3 is required for myocardial trabeculation

Nature Communications
Failure of proper ventricular trabeculation is often associated with congenital heart disease. Support from endocardial cells, including the secretion of extracellular matrix and growth factors is critical for trabeculation.
Jihyun Jang, Mette Bentsen, Ye Jun Kim, Erick Kim, Vidu Garg, Chen-Leng Cai, Mario Looso, Deqiang Li   +7 more
doaj   +1 more source

Histone deacetylase 3 gene in hematopoietic stem cells promotes mouse lymphogenesis

Di-san junyi daxue xuebao, 2019
Objective To investigate the role of histone deacetylase 3 gene (Hdac3) in hematopoiesis by developing a conditional Hdac3 knockout mice. Methods We crossed the Hdac3floxp/floxp mice with Mx1-Cre mice to generate Hdac3fl/flMx1-Cre mice, and then ...
LYU Wenqiong, SHU Yi, YANG Bijie, ZHANG Hang   +3 more
doaj   +1 more source

Histone deacetylase inhibitors

Journal of Education, Health and Sport, 2020
The human genome is contained in chromatin, which is a complex macromolecular complex. It is made of DNA, histones and non-histone proteins. The structure of chromatin and the process of its rearrangement regulate the process of transcription, and hence ...
Marzena Baran, Paulina Anna Miziak, Katarzyna Bonio   +2 more
doaj   +1 more source

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation [PDF]

Genes & Development, 2011
Macrophages, a key cellular component of inflammation, become functionally polarized in a signal- and context-specific manner. Th2 cytokines such as interleukin 4 (IL-4) polarize macrophages to a state of alternative activation that limits inflammation and promotes wound healing.
Mullican, Shannon E., Gaddis, Christine A., Alenghat, Theresa, Nair, Meera G., Giacomin, Paul R., Everett, Logan J., Feng, Dan, Steger, David J., Schug, Jonathan, Artis, David, Lazar, Mitchell A.   +10 more
openaire   +3 more sources