Results 41 to 50 of about 18,392,427 (194)
Entinostat-Bortezomib Hybrids against Multiple Myeloma
Molecules, 2023 Although proteasome inhibitors have emerged as the therapeutic backbone of multiple myeloma treatment, patients often relapse and become drug refractory. The combination between proteasome and histone deacetylase inhibitors has shown to be more efficient
Angelica Ferro +4 more
doaj +1 more source
Dissecting the roles of histone deacetylase 1 and 2 in the hematopoietic system [PDF]
, 2008 Reversible histone acetylation on lysine residues has been intensively studied as an epigenetic mark for gene activation in a variety of eukaryotes. Histone deacetylases (HDACs) act to repress gene expression by removing acetyl groups from histones and ...
Yamaguchi, Teppei
core +1 more source
Translational Oncology, 2016 Background: The current chemotherapeutic outcomes for hepatocellular carcinoma (HCC) are not encouraging, and long-term survival of this patient group remains poor.
Jing Liu +9 more
doaj +1 more source
Role for histone deacetylase 3 in maintenance of genome stability [PDF]
Cell Cycle, 2011 Histone deacetylase 3 (Hdac3) is the catalytic enzyme in a transcriptional repression complex that contains the nuclear hormone co-repressors (N-CoR or SMRT). As such, Hdac3 has largely been studied in the context of gene regulation of targets of nuclear hormone receptors and other transcription factors that recruit these corepressors.
Srividya, Bhaskara, Scott W, Hiebert
openaire +2 more sources
Haematologica, 2010 Background During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are ...
Peng Ji +4 more
doaj +1 more source
Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer [PDF]
, 2008 Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours.
Dietel Manfred +21 more
core +1 more source
Histone deacetylases facilitate the accurate repair of broken forks
Molecular & Cellular Oncology, 2020 We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and ...
Belén Gómez-González +2 more
doaj +1 more source
The deacetylase HDAC6 is an essential component of stress granules and plays a critical role in the cellular response to stress [PDF]
, 2007 The reversible acetylation of histones has a critical role in transcriptional regulation. Likewise reversible acetylation of non-histones proteins is also important for other cellular processes.
Kwon, So Hee
core +1 more source
Histone Deacetylase 3 Is Necessary for Proper Brain Development [PDF]
Journal of Biological Chemistry, 2014 The functional role of histone deacetylase 3 (HDAC3) in the developing brain has yet to be elucidated. We show that mice lacking HDAC3 in neurons and glia of the central nervous system, Nes-Cre/HDAC3 conditional KO mice, show major abnormalities in the cytoarchitecture of the neocortex and cerebellum and die within 24 h of birth.
Jordan, Norwood +3 more
openaire +2 more sources
Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo [PDF]
, 2013 Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents.
Eva Juengel +13 more
core +2 more sources