Results 41 to 50 of about 157,390 (295)

Histone deacetylase inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1

Scientific Reports, 2023
Metastasis is a leading cause of mortality in patients with lung adenocarcinoma. Histone deacetylases have emerged as promising targets for anti-tumor drugs, with histone deacetylase inhibitors (HDACi) being an active area of research.
Dongmei Wang, Yixiao Yang, Yuxiang Cao, Meiyao Meng, Xiaobo Wang, Zhengxun Zhang, Wei Fu, Shichao Duan, Liming Tang   +8 more
doaj   +1 more source

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection. [PDF]

, 2017
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality.
Alland, Aung, Azad, Bannister, Barchowsky, Bell, Bird, Brilha, Chen, Chernov, Choudhary, Culley, de Ruijter, Dobaczewski, Elkington, Feng, Goldberg, Green, Gregoire, Gregoretti, Horiuchi, Jaspers, Khan, Kim, Kleinsteuber, Kubler, Kumar, Lee, Loffek, Lu, Maciejewska-Rodrigues, Majeed, McErlean, McGarry Houghton, Michael, Mittelstadt, Mortaz, Moser, Nasu, Omanakuttan, Ong, Ong, Roger, Shahbazian, Shammari, Singh, Swamy, Tezera, Thuong, Wallis, Wang, Wang, Wolffe   +52 more
core   +2 more sources

Histone Deacetylase 3 Is Required for T Cell Maturation [PDF]

The Journal of Immunology, 2015
Abstract Recent thymic emigrants are newly generated T cells that need to undergo postthymic maturation to gain functional competency and enter the long-lived naive T cell pool. The mechanism of T cell maturation remains incompletely understood.
Fan-Chi, Hsu, Paul J, Belmonte, Megan M, Constans, Meibo W, Chen, Douglas C, McWilliams, Scott W, Hiebert, Virginia Smith, Shapiro   +6 more
openaire   +2 more sources

Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma [PDF]

Experimental Hematology & Oncology, 2021
Abstract Background Multiple myeloma (MM) is a type of hematological malignancy affecting the functions of plasma cells. The treatment of MM patients has changed dramatically with the use of new agents. However, unfortunately, it is still incurable.
Seiichi Okabe, Yuko Tanaka, Akihiko Gotoh   +2 more
openaire   +3 more sources

Exploration of the Molecular Mechanism for Lipoprotein Lipase Expression Variations in SH-SY5Y Cells Exposed to Different Doses of Amyloid-Beta Protein

Frontiers in Aging Neuroscience, 2020
Progressive accumulation of amyloid-β (Aβ) plaques in the brain is a characteristic pathological change in Alzheimer’s disease (AD). We previously found the expression of lipoprotein lipase (LPL) was increased in SH-SY5Y cells exposed to low-dose Aβ and ...
Jingzhu Zhang, Yufan Liu, Sihui Wang, Ran Que, Weidong Zhao, Weidong Zhao, Li An   +6 more
doaj   +1 more source

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

Cell Discovery, 2023
Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function.
Jialun Li, Lu Lu, Lingling Liu, Xuelian Ren, Jiwei Chen, Xingzhi Yin, Yanhui Xiao, Jiwen Li, Gang Wei, He Huang, Wei Wei, Jiemin Wong   +11 more
doaj   +1 more source

New insights into the epigenetic control of satellite cells [PDF]

, 2015
Epigenetics finely tunes gene expression at a functional level without modifying the DNA sequence, thereby contributing to the complexity of genomic regulation.
Adamo, Sergio, Marroncelli, Nicoletta, Moresi, Viviana   +2 more
core   +1 more source

The histone deacetylase-3 complex contains nuclear receptor corepressors [PDF]

Proceedings of the National Academy of Sciences, 2000
Acetylation and deacetylation of nucleosomal histones have profound effects on gene transcription in all eukaryotes. In humans, three highly homologous class I and four class II histone deacetylase (HDAC) enzymes have been identified to date.
Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E   +7 more
openaire   +3 more sources

Mycobacterium tuberculosis Phosphoribosyltransferase Promotes Bacterial Survival in Macrophages by Inducing Histone Hypermethylation in Autophagy-Related Genes

Frontiers in Cellular and Infection Microbiology, 2021
Mycobacterium tuberculosis (Mtb) inhibits autophagy to promote its survival in host cells. However, the molecular mechanisms by which Mtb inhibits autophagy are poorly understood.
Srabasti Sengupta, Barsa Nayak, Michael Meuli, Peter Sander, Peter Sander, Snehasish Mishra, Avinash Sonawane   +6 more
doaj   +1 more source

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells [PDF]

, 2018
Sirtuin 6 (SIRT6) is a member of the NAD+-dependent class III deacetylase sirtuin family, which plays a key role in cancer by controlling transcription, genome stability, telomere integrity, DNA repair, and autophagy.
Annamaria Biroccio, And, Del Bufalo, Donatella, Di Leo, Luca, Iachettini, Sara, Leonetti, Carlo, Lucidi, Alessia, Mai, Antonello, Rizzo, Angela, Rosa Ciriolo, Maria, Rotili, Dante, Salvati, Erica, Steegborn, Clemens, Trisciuoglio, Daniela, Zizza, Pasquale   +13 more
core   +2 more sources