Results 21 to 30 of about 157,390 (295)
Histone deacetylase 3 indirectly modulates tubulin acetylation [PDF]
Biochemical Journal, 2015 Histone deacetylase 3 (HDAC3), a member of the Class I subfamily of HDACs, is found in both the nucleus and the cytoplasm. Its roles in the nucleus have been well characterized, but its cytoplasmic roles are still not elucidated fully. We found that blocking HDAC3 activity using MI192, a compound specific for HDAC3, modulated tubulin acetylation in the
Bacon, Travis J +7 more
openaire +5 more sources
Regulation of Histone Acetyltransferase TIP60 Function by Histone Deacetylase 3 [PDF]
Journal of Biological Chemistry, 2014 The key member of the MOZ (monocyticleukaemia zinc finger protein), Ybf2/Sas3, Sas2, and TIP60 acetyltransferases family, Tat-interactive protein, 60 kD (TIP60), tightly modulates a wide array of cellular processes, including chromatin remodeling, gene transcription, apoptosis, DNA repair, and cell cycle arrest.
Jingjie, Yi +5 more
openaire +2 more sources
Integrative regulation of physiology by histone deacetylase 3. [PDF]
Nat Rev Mol Cell Biol, 2019 Cell-type-specific gene expression is physiologically modulated by the binding of transcription factors to genomic enhancer sequences, to which chromatin modifiers such as histone deacetylases (HDACs) are recruited. Drugs that inhibit HDACs are in clinical use but lack specificity.
Emmett MJ, Lazar MA.
europepmc +4 more sources
HDAC3 (histone deacetylase 3) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HDAC3 (histone deacetylase 3), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +1 more source
Frontiers in Molecular Neuroscience, 2017 The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer’s disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain.
Jingzhu Zhang +8 more
doaj +1 more source
Inhibition of histone deacetylase as a treatment for cardiac hypertrophy [PDF]
, 2005 The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac ...
Bristow, Michael R. +3 more
core +1 more source
Entinostat-Bortezomib Hybrids against Multiple Myeloma
Molecules, 2023 Although proteasome inhibitors have emerged as the therapeutic backbone of multiple myeloma treatment, patients often relapse and become drug refractory. The combination between proteasome and histone deacetylase inhibitors has shown to be more efficient
Angelica Ferro +4 more
doaj +1 more source
A pancancer analysis of histone deacetylase 3 in human tumors. [PDF]
Transl Cancer ResHistone deacetylase 3 (HDAC3) is known to be an important role in various kinds of cancer, but its effect has not been examined on the pancancer level. Thus, a systematic pancancer analysis was conducted to explore its potential role in pancancer diagnosis, prognosis, and immune correlation research.We used a series of databases including The Cancer ...
Chen H +6 more
europepmc +3 more sources
Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation [PDF]
, 2017 Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Albert, Brice J +8 more
core +2 more sources
MiR-376a and Histone Deacetylation 9 Form A Regulatory Circuitry in Hepatocellular Carcinoma
Cellular Physiology and Biochemistry, 2015 Background/Aims: Our previous study has demonstrated that down-regulation of miR-376a might contribute to the development of hepatocellular carcinoma (HCC), but the mechanism underlying this down-regulation remains obscure.
Yongxia Zheng +8 more
doaj +1 more source