Results 21 to 30 of about 18,392,427 (194)

Histone deacetylase 3 inhibition alleviates type 2 diabetes mellitus-induced endothelial dysfunction via Nrf2 [PDF]

Cell Communication and Signaling, 2021
Background The mechanism underlying endothelial dysfunction leading to cardiovascular disease in type 2 diabetes mellitus (T2DM) remains unclear. Here, we show that inhibition of histone deacetylase 3 (HDAC3) reduced inflammation and oxidative stress by ...
Shuai Huang, Gen Chen, Jia Sun, Yunjie Chen, Nan Wang, Yetong Dong, Enzhao Shen, Zhicheng Hu, Wenjie Gong, Litai Jin, Weitao Cong   +10 more
doaj   +2 more sources

Histone Deacetylase 3: A Potential Therapeutic Target for Atherosclerosis. [PDF]

Aging Dis, 2022
Atherosclerosis, the pathological basis of most cardiovascular disease, is characterized by plaque formation in the intima. Secondary lesions include intraplaque hemorrhage, plaque rupture, and local thrombosis. Vascular endothelial function impairment and smooth muscle cell migration lead to vascular dysfunction, which is conducive to the formation of
Jiang LP, Yu XH, Chen JZ, Hu M, Zhang YK, Lin HL, Tang WY, He PP, Ouyang XP.   +8 more
europepmc   +3 more sources

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases [PDF]

Science Advances, 2022
Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with functions that are different from the widely studied histone acetylation.
Moreno-Yruela, Carlos, Zhang, Di, Wei, Wei, Bæk, Michael, Liu, Wenchao, Gao, Jinjun, Danková, Daniela, Nielsen, Alexander L., Bolding, Julie E., Yang, Lu, Jameson, Samuel T., Wong, Jiemin, Olsen, Christian A., Zhao, Yingming   +13 more
openaire   +7 more sources

Histone deacetylase-3: Friend and foe of the brain. [PDF]

Exp Biol Med (Maywood), 2020
Histone deacetylases (HDACs) are a family of enzymes that deacetylate histones as well as a large number of other nuclear, cytoplasmic, and mitochondrial proteins. The deacetylation of histones transforms chromatin to a transcriptionally repressed state, whereas deacetylation of other cellular proteins regulates their functional activity through ...
D'Mello SR.
europepmc   +4 more sources

Efferocytosis and retinal clean-up: Role of histone deacetylase 3 in ischemic retinopathy [PDF]

Neural Regeneration Research
Abdelrahman Y. Fouda, Esraa Shosha
doaj   +2 more sources

A pancancer analysis of histone deacetylase 3 in human tumors. [PDF]

Transl Cancer Res
Histone deacetylase 3 (HDAC3) is known to be an important role in various kinds of cancer, but its effect has not been examined on the pancancer level. Thus, a systematic pancancer analysis was conducted to explore its potential role in pancancer diagnosis, prognosis, and immune correlation research.We used a series of databases including The Cancer ...
Chen H, Xu F, Qin A, Guo S, Zhang G, Yu B, Zheng Q.   +6 more
europepmc   +3 more sources

Functional Domains of Histone Deacetylase-3 [PDF]

Journal of Biological Chemistry, 2002
Post-translational modifications of histones, in general, and acetylation/deacetylation, in particular, can dramatically alter gene expression in eukaryotic cells. In humans, four highly homologous class I HDAC enzymes (HDAC1, HDAC2, HDAC3, and HDAC8) have been identified to date.
Wen-Ming, Yang, Shih-Chang, Tsai, Yu-Der, Wen, Gyorgy, Fejer, Edward, Seto   +4 more
openaire   +2 more sources

Histone Deacetylase 3 Regulates Cyclin A Stability [PDF]

Journal of Biological Chemistry, 2013
PCAF and GCN5 acetylate cyclin A at specific lysine residues targeting it for degradation at mitosis. We report here that histone deacetylase 3 (HDAC3) directly interacts with and deacetylates cyclin A. HDAC3 interacts with a domain included in the first 171 aa of cyclin A, a region involved in the regulation of its stability.
Vidal-Laliena, Miriam, Gallastegui, Edurne, Mateo, Francesca, Martínez-Balbás, Marian, Pujol, María Jesús, Bachs, Oriol   +5 more
openaire   +3 more sources

Integrative regulation of physiology by histone deacetylase 3. [PDF]

Nat Rev Mol Cell Biol, 2019
Cell-type-specific gene expression is physiologically modulated by the binding of transcription factors to genomic enhancer sequences, to which chromatin modifiers such as histone deacetylases (HDACs) are recruited. Drugs that inhibit HDACs are in clinical use but lack specificity.
Emmett MJ, Lazar MA.
europepmc   +4 more sources

Regulation of Histone Acetyltransferase TIP60 Function by Histone Deacetylase 3 [PDF]

Journal of Biological Chemistry, 2014
The key member of the MOZ (monocyticleukaemia zinc finger protein), Ybf2/Sas3, Sas2, and TIP60 acetyltransferases family, Tat-interactive protein, 60 kD (TIP60), tightly modulates a wide array of cellular processes, including chromatin remodeling, gene transcription, apoptosis, DNA repair, and cell cycle arrest.
Jingjie, Yi, Xiangyang, Huang, Yuxia, Yang, Wei-Guo, Zhu, Wei, Gu, Jianyuan, Luo   +5 more
openaire   +2 more sources