Results 11 to 20 of about 157,390 (295)
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions
EMBO Molecular Medicine, 2014 Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management.
Marten A Hoeksema +22 more
doaj +6 more sources
Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus [PDF]
Virology Journal, 2011 Evidence suggests that genome chromatinization and the posttranslational modification of histones are involved in the regulation of viral gene expression, including the human cytomegalovirus (HCMV).
Wang Weijia +5 more
doaj +3 more sources
Histone deacetylase 3 is required for iNKT cell development
Scientific Reports, 2017 NKT cells are a distinct subset that have developmental requirements that often differ from conventional T cells. Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction in the number of iNKT cells, particularly of NKT1 cells.
Puspa Thapa +4 more
doaj +3 more sources
Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation.
PLoS ONE, 2014 Regulator of calcineurin 1 (RCAN1; also referred as DSCR1 or MCIP1) is located in close proximity to a Down syndrome critical region of human chromosome 21.
Kyung Ah Han +8 more
doaj +5 more sources
Histone Deacetylase 3: A Potential Therapeutic Target for Atherosclerosis. [PDF]
Aging Dis, 2022 Atherosclerosis, the pathological basis of most cardiovascular disease, is characterized by plaque formation in the intima. Secondary lesions include intraplaque hemorrhage, plaque rupture, and local thrombosis. Vascular endothelial function impairment and smooth muscle cell migration lead to vascular dysfunction, which is conducive to the formation of
Jiang LP +8 more
europepmc +3 more sources
Class I histone deacetylases (HDAC1–3) are histone lysine delactylases [PDF]
Science Advances, 2022 Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with functions that are different from the widely studied histone acetylation.
Moreno-Yruela, Carlos +13 more
openaire +6 more sources
Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs. [PDF]
Chem Commun (Camb), 2020 Potent and histone deacetylase 3 (HDAC3)-specific PROTAC XZ9002 is reported here.
Xiao Y +6 more
europepmc +4 more sources
Histone deacetylase-3: Friend and foe of the brain. [PDF]
Exp Biol Med (Maywood), 2020 Histone deacetylases (HDACs) are a family of enzymes that deacetylate histones as well as a large number of other nuclear, cytoplasmic, and mitochondrial proteins. The deacetylation of histones transforms chromatin to a transcriptionally repressed state, whereas deacetylation of other cellular proteins regulates their functional activity through ...
D'Mello SR.
europepmc +4 more sources
Functional Domains of Histone Deacetylase-3 [PDF]
Journal of Biological Chemistry, 2002 Post-translational modifications of histones, in general, and acetylation/deacetylation, in particular, can dramatically alter gene expression in eukaryotic cells. In humans, four highly homologous class I HDAC enzymes (HDAC1, HDAC2, HDAC3, and HDAC8) have been identified to date.
Wen-Ming, Yang +4 more
openaire +2 more sources
Histone Deacetylase 3 Regulates Cyclin A Stability [PDF]
Journal of Biological Chemistry, 2013 PCAF and GCN5 acetylate cyclin A at specific lysine residues targeting it for degradation at mitosis. We report here that histone deacetylase 3 (HDAC3) directly interacts with and deacetylates cyclin A. HDAC3 interacts with a domain included in the first 171 aa of cyclin A, a region involved in the regulation of its stability.
Vidal-Laliena, Miriam +5 more
openaire +3 more sources