Histone deacetylase 3 regulates microglial function through histone deacetylation [PDF]
Epigenetics, 2023 As the primary innate immune cells of the brain, microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules.
Laura Meleady +6 more
doaj +4 more sources
Regulation of pDC fate determination by histone deacetylase 3 [PDF]
eLife, 2023 Dendritic cells (DCs), the key antigen-presenting cells, are primary regulators of immune responses. Transcriptional regulation of DC development had been one of the major research interests in DC biology; however, the epigenetic regulatory mechanisms ...
Yijun Zhang +7 more
doaj +4 more sources
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation [PDF]
eLife, 2021 After antigenic activation, quiescent naive CD4+ T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides, amino acids, fatty acids, and sterols.
Drew Wilfahrt +9 more
doaj +2 more sources
HDAC3 (histone deacetylase 3) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HDAC3 (histone deacetylase 3), with data on DNA, on the protein encoded, and where the gene is implicated.
Escaffit, F
openaire +3 more sources
Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus [PDF]
Virology Journal, 2011 Evidence suggests that genome chromatinization and the posttranslational modification of histones are involved in the regulation of viral gene expression, including the human cytomegalovirus (HCMV).
Wang Weijia +5 more
doaj +3 more sources
Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis [PDF]
Nature Communications, 2020 Alveolar macrophages are known to derive from embryonic precursors although the regulation of this process is poorly understood. Here the authors propose a key role for histone deacetylase 3 as an epigenetic regulator of lung alveolar macrophage ...
Yi Yao +11 more
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Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1 [PDF]
Protein & Cell, 2020 TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still remains to be uncovered.
Jie-lin Tang +14 more
doaj +2 more sources
Histone deacetylase 3 is required for iNKT cell development
Scientific Reports, 2017 NKT cells are a distinct subset that have developmental requirements that often differ from conventional T cells. Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction in the number of iNKT cells, particularly of NKT1 cells.
Puspa Thapa +4 more
doaj +3 more sources
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions
EMBO Molecular Medicine, 2014 Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management.
Marten A Hoeksema +22 more
doaj +6 more sources
The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors [PDF]
Molecules, 2018 Histone deacetylases (HDACs) are epigenetic drug targets that have gained major scientific attention. Inhibition of these important regulatory enzymes is used to treat cancer, and has the potential to treat a host of other diseases.
Fangyuan Cao +2 more
doaj +3 more sources