Results 31 to 40 of about 1,119 (155)

Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury [PDF]

Journal of Ocular Pharmacology and Therapeutics, 2018
HDAC3 regulates nuclear atrophy as an early response to axonal injury in retinal ganglion cells (RGCs) following optic nerve crush (ONC). Since conditional knockout of Hdac3 prevents nuclear atrophy post ONC, HDAC3 selective inhibition with RGFP966 through localized and systemic dosing of RGFP966 is necessary for application to acute and chronic models
Heather M, Schmitt, Cassandra L, Schlamp, Robert W, Nickells   +2 more
openaire   +2 more sources

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation [PDF]

, 2018
The transcription factor NF-κB is a critical regulator of immune and inflammatory responses. In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel, and Rel-B proteins, which form homo- or heterodimers and remain as an ...
Giridharan, Sivagami, Srinivasan, Mythily   +1 more
core   +1 more source

Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth [PDF]

, 2016
Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacological inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity and other diseases.
Cheng, Zhou-Li, Ding, Chen, Groh, Beezly S., Guan, Kun-Liang, He, Ruo-Yu, Ji, Min-Biao, Lin, Huai-Peng, Liu, Wei-Ren, Shi, Ying-Hong, Song, Lei, Tian, Meng-Xin, Xiong, Yue, Ye, Dan, Zhou, Li-Sha   +13 more
core   +2 more sources

LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and α-synuclein-induced degeneration in cellular models of Parkinson's disease [PDF]

, 2021
Epigenetic modifications in neurodegenerative disease are under investigation for their roles in disease progression. Alterations in acetylation rates of certain Parkinson's disease (PD)-linked genes have been associated with the pathological progression
Collins, Louise M., Goulding, Susan R., Mazzocchi, Martina, O'Keeffe, Gerard W., Sullivan, Aideen M., Wyatt, Sean L.   +5 more
core   +1 more source

Hsp90 chaperone facilitates E2F1/2-dependent gene transcription in human breast cancer cells

European Journal of Cell Biology, 2021
The 90 kDa heat shock protein, Hsp90, is involved in the conformational stabilization and functional maturation of diverse cancer-promoting proteins.
Akhil Kotwal, Sourabh Suran, Sreedhar Amere Subbarao   +2 more
doaj   +1 more source

Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway. [PDF]

Burns Trauma
Abstract Background Oxidative stress (OS) and inflammatory reactions play pivotal roles in secondary brain injury after traumatic brain injury (TBI). Histone deacetylase 3 (HDAC3) controls the acetylation of histones and non-histones, which has a significant impact on the central nervous system’s ...
Xu L, An T, Jia B, Wu Q, Shen J, Jin J, Liu J, Li C.   +7 more
europepmc   +3 more sources

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis. [PDF]

Adv Sci (Weinh)
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Sun M, Zhang Y, Mao R, Chen Y, Liu P, Ye L, Xu S, Jia J, Shu S, Li H, Yin Y, Xia S, Chen Y, Xu Y.   +13 more
europepmc   +2 more sources

HDAC3 is essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1 [PDF]

, 2019
Therapy of acute myeloid leukemia (AML) is unsatisfactory. Histone deacetylase inhibitors (HDACi) are active against leukemic cells in vitro and in vivo.
Beyer, M., Mustafa, Al-Hassan M., Romanski, A., Sellmer, Andreas   +3 more
core   +1 more source

Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia

Neural Plasticity, 2017
HDAC3 has been shown to regulate inflammation. However, the role of HDAC3 in primary microglia is largely unknown. RGFP966 is a newly discovered selective HDAC3 inhibitor. In this study, we used protein mass spectrometry to analyze protein alterations in
Mingxu Xia, Qiuchen Zhao, He Zhang, Yanting Chen, Zengqiang Yuan, Yun Xu, Meijuan Zhang   +6 more
doaj   +1 more source

The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro

Frontiers in Physiology, 2019
Osteoarthritis (OA) is a disease characterized by non-bacterial inflammation. Histone deacetylase 3 (HDAC3) is a crucial positive regulator in the inflammation that leads to the development of non-OA inflammatory disease. However, the precise involvement
He Zhang, Lu Ji, Yue Yang, Yingliang Wei, Xiaoning Zhang, Yi Gang, Jinghan Lu, Lunhao Bai   +7 more
doaj   +1 more source