Results 31 to 40 of about 888 (124)

Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury [PDF]

Journal of Ocular Pharmacology and Therapeutics, 2017
Abstract Purpose: HDAC3 regulates nuclear atrophy as an early response to axonal injury in retinal ganglion cells (RGCs) following optic nerve crush (ONC). Since conditional knockout of Hdac3 prevents nuclear atrophy post ONC ...
Heather M, Schmitt, Cassandra L, Schlamp, Robert W, Nickells   +2 more
openaire   +2 more sources

Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia

Neural Plasticity, 2017
HDAC3 has been shown to regulate inflammation. However, the role of HDAC3 in primary microglia is largely unknown. RGFP966 is a newly discovered selective HDAC3 inhibitor. In this study, we used protein mass spectrometry to analyze protein alterations in
Mingxu Xia, Qiuchen Zhao, He Zhang, Yanting Chen, Zengqiang Yuan, Yun Xu, Meijuan Zhang   +6 more
doaj   +1 more source

Hsp90 chaperone facilitates E2F1/2-dependent gene transcription in human breast cancer cells

European Journal of Cell Biology, 2021
The 90 kDa heat shock protein, Hsp90, is involved in the conformational stabilization and functional maturation of diverse cancer-promoting proteins.
Akhil Kotwal, Sourabh Suran, Sreedhar Amere Subbarao   +2 more
doaj   +1 more source

The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro

Frontiers in Physiology, 2019
Osteoarthritis (OA) is a disease characterized by non-bacterial inflammation. Histone deacetylase 3 (HDAC3) is a crucial positive regulator in the inflammation that leads to the development of non-OA inflammatory disease. However, the precise involvement
He Zhang, Lu Ji, Yue Yang, Yingliang Wei, Xiaoning Zhang, Yi Gang, Jinghan Lu, Lunhao Bai   +7 more
doaj   +1 more source

Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway

Pharmaceutical Biology, 2023
Context di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing formulations (BSTJFs) are beneficial for female reproductive capacity.
Hui Zhang, Huihua Wang, Qing Zhang, Hui Wang, Yuhang Zhu, Fangfang Wang, Jun Lin, Jue Zhou, Fan Qu   +8 more
doaj   +1 more source

The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice.

PLoS ONE, 2016
An important epigenetic modification in Huntington's disease (HD) research is histone acetylation, which is regulated by histone acetyltransferase and histone deacetylase (HDAC) enzymes.
Haiqun Jia, Ying Wang, Charles D Morris, Vincent Jacques, Joel M Gottesfeld, James R Rusche, Elizabeth A Thomas   +6 more
doaj   +1 more source

Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension.

PLoS ONE, 2019
OBJECTIVE:Non-selective histone deacetylase (HDAC) inhibitors are known to improve hypertension. Here, we investigated the therapeutic effect and regulatory mechanism of the class I HDAC selective inhibitors, MS-275 and RGFP966, in angiotensin (Ang) II ...
Yuhee Ryu, Hae Jin Kee, Simei Sun, Young Mi Seok, Sin Young Choi, Gwi Ran Kim, Seung-Jung Kee, Marc Pflieger, Thomas Kurz, Hyung-Seok Kim, Myung Ho Jeong   +10 more
doaj   +1 more source

A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice

Scientific Reports, 2017
Huntington’s disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families.
Nuria Suelves, Lucy Kirkham-McCarthy, Robert S. Lahue, Silvia Ginés   +3 more
doaj   +1 more source

HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control

Redox Biology, 2023
Sepsis is one common cause of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which is closely associated with high mortality in intensive care units (ICU). Histone deacetylase 3 (HDAC3) serves as an important epigenetic modifying
Ning Li, Bohao Liu, Rui Xiong, Guorui Li, Bo Wang, Qing Geng   +5 more
doaj   +1 more source

Inhibition of HDAC3 Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice In Vivo and In Vitro

Journal of Diabetes Research, 2019
Background. A substantial increase in histone deacetylase 3 (HDAC3) expression is implicated in the pathological process of diabetes and stroke. However, it is unclear whether HDAC3 plays an important role in diabetes complicated with stroke. We aimed to
Bo Zhao, Quan Yuan, Jia-bao Hou, Zhong-yuan Xia, Li-ying Zhan, Mei Li, Meng Jiang, Wen-wei Gao, Lian Liu   +8 more
doaj   +1 more source