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Sulfur-and selenium-targeting warheads: reaction-based design of electrophilic warheads for selective inhibition of enzyme

Frontiers in Chemistry
Covalent inhibitors for nucleophilic residues, particularly cysteine (Cys) and selenocysteine (Sec), have resurfaced as precision therapies for modifying disease-associated enzymes.
Neha Jain, Michio Iwaoka, Michio Iwaoka
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Purification of vegetable oils from acrylamide pollutants using metal-organic frameworks

Scientific Reports
Acrylamide is a chemical compound that can form in certain foods during high-temperature cooking processes like frying, roasting, and baking. The presence of acrylamide in used cooking oil has environmental impact; therefore, the purification of used ...
Reda M. Abdelhameed, Randa S. Hasan, Hassan Abdel-Gawad +2 more
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Synthesis and Antioxidant Activities of Novel Pyrimidine Acrylamides as Inhibitors of Lipoxygenase: Molecular Modeling and In Silico Physicochemical Studies

Molecules
The pyrimidine ring is present in various biomolecules such as DNA and RNA bases, aminoacids, vitamins, etc. Additionally, many clinically used drugs including methotrexate and risperidone contain the pyrimidine heterocyclic scaffold as well.
Michail Saragatsis, Eleni Pontiki
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Acrylamide