Results 51 to 60 of about 888 (124)

Butyrate Ameliorates Insufficient Sleep-Induced Intestinal Mucosal Damage in Humans and Mice

Microbiology Spectrum, 2023
Insufficient sleep is a key factor in the occurrence of intestinal diseases. This study was performed to clarify how sleep deficiency mediates the intestinal microbiota, metabolite butyrate disturbance induces intestinal mucosal damage, and butyrate ...
Ting Gao, Zixu Wang, Yulan Dong, Jing Cao, Yaoxing Chen   +4 more
doaj   +1 more source

N6‐Methyladenosine Modification of circIST1 Promotes Hypoxia‐Inducible Factor α–mediated Glycolysis and Progression in Hepatocellular Carcinoma

MedComm, Volume 7, Issue 1, January 2026.
We identified first time a critical m6A modification of circIST1 on miR‐140‐3p/miR‐182‐HIF1α regulatory network involved in the HCC progression and tumor glycolysis, gaining mechanistic insights into the function of circRNAs in HCC progression. ABSTRACT The involvement of circular RNAs (circRNAs) have been well‐documented in various cancers, including ...
Yangyang Zhan, Zhongmin Wang, Fei Teng, Qian Ding, Lei Lv, Fangyuan Xie, Yueying Huang, Xue Jiang, Dan Zheng, Xiaoying Ge, Shuqun Cheng, Yizhun Zhu, Leilei Bao   +12 more
wiley   +1 more source

Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells

iScience, 2019
Summary: We report that cerebrum-specific inactivation of the histone deacetylase 3 (HDAC3) gene causes striking developmental defects in the neocortex, hippocampus, and corpus callosum; post-weaning lethality; and abnormal behaviors, including ...
Lin Li, Jianliang Jin, Xiang-Jiao Yang
doaj   +1 more source

Spatiotemporal Heterogeneity of Macrophages in Acute Pancreatitis: From Inflammatory Initiators to Repair Coordinators and Targeted Therapeutics

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
The current management of acute pancreatitis (AP) primarily relies on supportive measures, such as fluid resuscitation, nutritional support, and infection control. However, these approaches do not adequately address the core drivers of the disease. This limitation arises from an incomplete understanding of the progression from local injury to systemic ...
Xiang Lu, Yu Zeng, Li-hong Gan, Li Li, Jian-qin Liu, Xin Zhou, Xiao-ning Jin, Chao-li Jiang, Zhi Li, Zoltan Rakonczay Jr.   +9 more
wiley   +1 more source

Tissue‐Resident Memory T Cells: Pioneering New Avenues in Cancer Immunotherapy

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Tissue‐resident memory T cells (TRM) are a specialized subset of memory T cells that reside in nonlymphoid tissues and draining lymph nodes, playing a critical role in immune surveillance and tumor immunity. Tumor‐infiltrated TRM have emerged as key players in immune checkpoint blockade (ICB) therapy, contributing to early ...
Yao Xiao, Qi‐Chao Yang, Zhi‐Jun Sun
wiley   +1 more source

Engineering exosomes for Alzheimer's disease: Multi‐target therapeutic strategies from pathogenesis to clinical translation

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
Exosomes, modified through multidimensional approaches including physical, chemical and genetic means, and equipped with brain‐targeted peptides and therapeutic agents, are capable of crossing the blood‒brain barrier for precise delivery. They can simultaneously remove amyloid‐beta plaques and neurofibrillary tangle, inhibit neuroinflammation, and pave
Yuehan Zhang, Zhenyang Li, Haien Guan, Zhenhua Qiu, Chunlin Zou   +4 more
wiley   +1 more source

Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

EMBO Molecular Medicine, 2018
AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other.
Yuqian Yan, Jian An, Yinhui Yang, Di Wu, Yang Bai, William Cao, Linlin Ma, Junhui Chen, Zhendong Yu, Yundong He, Xin Jin, Yunqian Pan, Tao Ma, Shangqian Wang, Xiaonan Hou, Saravut John Weroha, R Jeffrey Karnes, Jun Zhang, Jennifer J Westendorf, Liguo Wang, Yu Chen, Wanhai Xu, Runzhi Zhu, Dejie Wang, Haojie Huang   +24 more
doaj   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, Volume 58, Issue 12, December 2025.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Dual HDAC and PARP inhibition restores STING signaling, enhances interferon response, and boosts antitumor immunity in STING‐deficient tumors. . Abstract The stimulator of interferon genes (STING)‐mediated innate immune pathway plays an important role in tumor immunosurveillance.
Chengzhou Mao, Weiwen Fan, Jiaqi Liu, Fangzhou Yang, Wenkai Li, Lulu Li, Zhichao Shi, Qinyuan Li, Zigao Yuan, Yuyang Jiang, Bizhu Chu   +10 more
wiley   +1 more source

Epigenetic Suppression of RASAL1 by HDAC3 and Cofactor YY1 Promotes Fibroblast–Myofibroblast Transition and Renal Fibrosis

Research
Fibroblast–myofibroblast transition (FMT) and the resultant renal fibrosis are central pathological features of chronic kidney disease (CKD). Epigenetic suppression of RASAL1 (Ras protein activator like 1), an antifibrotic regulator in fibroblasts, is a ...
Fang Chen, Lijun Zhang, Weiying Liu, Bingbing Zhang, Shuren Wang, Zhengdong Zhou, Wei Wang, Jiansong Shen, Yijun Deng, Wangsen Cao   +9 more
doaj   +1 more source