Results 51 to 60 of about 1,119 (155)
Cell Communication and Signaling, 2021 Background The mechanism underlying endothelial dysfunction leading to cardiovascular disease in type 2 diabetes mellitus (T2DM) remains unclear. Here, we show that inhibition of histone deacetylase 3 (HDAC3) reduced inflammation and oxidative stress by ...
Shuai Huang +10 more
doaj +1 more source
Does stress remove the HDAC brakes for the formation and persistence of long-term memory? [PDF]
, 2014 It has been known for numerous decades that gene expression is required for long-lasting forms of memory. In the past decade, the study of epigenetic mechanisms in memory processes has revealed yet another layer of complexity in the regulation of gene ...
White, André O, Wood, Marcelo A
core +1 more source
Journal of Diabetes Research, 2019 Background. A substantial increase in histone deacetylase 3 (HDAC3) expression is implicated in the pathological process of diabetes and stroke. However, it is unclear whether HDAC3 plays an important role in diabetes complicated with stroke. We aimed to
Bo Zhao +8 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2016 Brain ischemic preconditioning (PC) provides vital insights into the endogenous protection against stroke. Genomic and epigenetic responses to PC condition the brain into a state of ischemic tolerance.
Xiaoyu Yang +3 more
doaj +1 more source
Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis [PDF]
, 2021 Worldwide, ∼196 million are afflicted with endometriosis, a painful disease in which endometrial tissue implants and proliferates on abdominal peritoneal surfaces. Theories on the origin of endometriosis remained inconclusive.
Ambati, Chandrasekhar R +8 more
core +2 more sources
Recent advances in the treatment of Charcot-Marie-Tooth neuropathies [PDF]
, 2023 Charcot-Marie-Tooth (CMT) neuropathies are one of the most common neuromuscular disorders. However, despite the identification of more than 100 causative genes, therapeutic options are still missing.
Alessandra Bolino, Maurizio D'Antonio
core +1 more source
Butyrate Ameliorates Insufficient Sleep-Induced Intestinal Mucosal Damage in Humans and Mice
Microbiology Spectrum, 2023 Insufficient sleep is a key factor in the occurrence of intestinal diseases. This study was performed to clarify how sleep deficiency mediates the intestinal microbiota, metabolite butyrate disturbance induces intestinal mucosal damage, and butyrate ...
Ting Gao +4 more
doaj +1 more source
Biochemical Pharmacology, 2016 The increasing number of patients suffering from chronic obstructive pulmonary disease (COPD) represents a major and increasing health problem. Therefore, novel therapeutic approaches are needed. Class I HDACs 1, 2 and 3 play key roles in the regulation of inflammatory gene expression with a particular pro-inflammatory role for HDAC 3.
Leus, Niek G.J. +9 more
openaire +3 more sources
Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue
iNew Medicine, EarlyView.ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao +3 more
wiley +1 more source
Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells
iScience, 2019 Summary: We report that cerebrum-specific inactivation of the histone deacetylase 3 (HDAC3) gene causes striking developmental defects in the neocortex, hippocampus, and corpus callosum; post-weaning lethality; and abnormal behaviors, including ...
Lin Li, Jianliang Jin, Xiang-Jiao Yang
doaj +1 more source