Results 61 to 70 of about 1,119 (155)
Medicinal chemistry advances in targeting class I histone deacetylases [PDF]
, 2023 Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gene expression at the DNA level.
Diaaeldin I. Abdallah +6 more
core +1 more source
BMEMat, Volume 4, Issue 1, March 2026.Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen +7 more
wiley +1 more source
DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu +12 more
wiley +1 more source
Histone Deacetylase Inhibitors as a Promising Treatment Against Myocardial Infarction: A Systematic Review [PDF]
Background/Objectives: Acute myocardial infarction (AMI) is a critical medical condition that requires immediate attention to minimise heart damage and improve survival rates.
Guerra Ojeda, Sol +4 more
core +2 more sources
MedComm, Volume 7, Issue 1, January 2026.We identified first time a critical m6A modification of circIST1 on miR‐140‐3p/miR‐182‐HIF1α regulatory network involved in the HCC progression and tumor glycolysis, gaining mechanistic insights into the function of circRNAs in HCC progression. ABSTRACT The involvement of circular RNAs (circRNAs) have been well‐documented in various cancers, including ...
Yangyang Zhan +12 more
wiley +1 more source
Evaluation of therapeutic targets for the treatment of behavioral alterations and neuropathology in Huntington’s disease. The role of histone deacetylase 3 and p75 neurotrophin receptor [PDF]
, 2018 [eng] Huntington’s disease (HD) is a rare genetic disorder caused by an aberrant expansion of a CAG trinucleotide in the huntingtin gene (Htt). The neuropathology of the disease is characterized by progressive neuronal dysfunction and degeneration in ...
Suelves Caballol, Núria
core +1 more source
Tissue‐Resident Memory T Cells: Pioneering New Avenues in Cancer Immunotherapy
Cancer Medicine, Volume 14, Issue 23, December 2025.ABSTRACT Background Tissue‐resident memory T cells (TRM) are a specialized subset of memory T cells that reside in nonlymphoid tissues and draining lymph nodes, playing a critical role in immune surveillance and tumor immunity. Tumor‐infiltrated TRM have emerged as key players in immune checkpoint blockade (ICB) therapy, contributing to early ...
Yao Xiao, Qi‐Chao Yang, Zhi‐Jun Sun
wiley +1 more source
Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.Exosomes, modified through multidimensional approaches including physical, chemical and genetic means, and equipped with brain‐targeted peptides and therapeutic agents, are capable of crossing the blood‒brain barrier for precise delivery. They can simultaneously remove amyloid‐beta plaques and neurofibrillary tangle, inhibit neuroinflammation, and pave
Yuehan Zhang +4 more
wiley +1 more source
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, Volume 58, Issue 12, December 2025.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source
Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma.
PLoS ONE, 2013 Given the fundamental roles of histone deacetylases (HDACs) in the regulation of DNA repair, replication, transcription and chromatin structure, it is fitting that therapies targeting HDAC activities are now being explored as anti-cancer agents. In fact,
Christina E Wells +14 more
doaj +1 more source