DEVELOPING AN IMMUNOMODULATORY STRATEGY USING BIOPHYSICAL CUES TO MODULATE MACROPHAGE PHENOTYPE FOR FRACTURE HEALING AND BONE REGENERATION [PDF]
Chronic inflammation is a major cause of the pathogenesis of musculoskeletal diseases such as fragility, fracture, and nonunion. Studies have shown that modulating the immune phenotype of macrophages from proinflammatory to pro-healing can heal ...
Suresh Kumar, Harshini
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Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration
Advanced Therapeutics, Volume 8, Issue 5, May 2025.Peripheral nerve injury is a common condition due to trauma that significantly impacts the life of the affected individual. This review explores the anatomy, classification, and pathophysiology of peripheral nerve injuries. It also discusses various types of nerve conduits and presents a detailed review of 3D bioprinted nerve conduits used in both in ...
Nasera Rizwana +5 more
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Mechanisms of TRAIL-resistance:novel targets to enhance TRAIL sensitization for cancer therapy [PDF]
, 2020 TRAIL has been shown to target tumor cells but not healthy cells in vitro. In addition, clinical studies have revealed that recombinant human TRAIL is well tolerated in patients.
Zhang, Baojie
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Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer
Advanced Science, Volume 12, Issue 12, March 27, 2025.HDAC inhibitor decreases HDAC1K412 lactylation to sensitize colorectal cancer to ferroptosis and the combination of HDAC inhibitor and ferroptosis inducers can be a promising therapeutic strategy for colorectal cancer. Abstract Colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti‐ferroptosis therapy. Through
Zhou Yang +17 more
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HDAC3 in action: Expanding roles in inflammation and inflammatory diseases
Cell Proliferation, Volume 58, Issue 1, January 2025.HDAC3, a member of the histone deacetylase (HDAC) superfamily, is involved in the regulation of acetylation/deacetylation processes associated with inflammation‐related diseases. This article reviews the key role of HDAC3 in the process of inflammation, the potential molecular mechanism and the clinical significance of targeted therapy.
Ruyuan He +6 more
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Journal of Neuroinflammation, 2019 Background Type 2 diabetes mellitus (T2DM) is a chronic metabolic dysfunction characterized by progressive insulin resistance and hyperglycaemia. Increased blood-brain barrier (BBB) permeability is a critical neurovascular complication of T2DM that ...
Qiuchen Zhao +8 more
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HDAC1 is a Required Cofactor of CBFβ-SMMHC and a Therapeutic Target in Inversion 16 Acute Myeloid Leukemia [PDF]
, 2019 Acute myeloid leukemia (AML) is a neoplastic disease characterized by the uncontrolled proliferation and accumulation of immature myeloid cells. A common mutation in AML is the inversion of chromosome 16 [inv(16)], which generates a fusion between the ...
Richter, Lisa E
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Histone Deacetylase Inhibitors Prevent Pulmonary Endothelial Hyperpermeability and Acute Lung Injury By Regulating Heat Shock Protein 90 Function [PDF]
, 2015 Transendothelial hyperpermeability caused by numerous agonists is dependent on heat shock protein 90 (Hsp90) and leads to endothelial barrier dysfunction (EBD). Inhibition of Hsp90 protects and restores transendothelial permeability.
Atul D. Joshi +15 more
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Recent Developments and Evolving Therapeutic Strategies in KMT2A‐Rearranged Acute Leukemia
Cancer Medicine, Volume 13, Issue 20, October 2024.ABSTRACT Background Rearrangements of the histone‐lysine‐N‐methyltransferase (KMT2A), previously referred to as mixed‐lineage leukemia (MLL), are among the most common chromosomal abnormalities in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), involving numerous different fusion partners.
Lei Yin +4 more
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The effect of butyrate on human macrophages:Immunomodulation and Epigenetic Regulation [PDF]
Butyrate is a short-chain fatty acid produced by gut microbiota during the fermentation of dietary fibers. Its concentration varies across regions of the body, especially in the gut.
Jiang, Muwei
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