YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction [PDF]
, 2020 Adverse cardiac remodeling after myocardial infarction (MI) causes structural and functional changes in the heart leading to heart failure. The initial post-MI pro-inflammatory response followed by reparative or anti-inflammatory response is essential ...
Cibi, Dasan Mary +8 more
core +1 more source
The FASEB Journal, Volume 38, Issue 10, 31 May 2024.Our study demonstrates that inhibition of HDAC3 (in cell lines N2a cells or in brain organotypic cultures) or knockdown of HDAC3 in N2a cells leads to changes in gene transcription, involving an increase in APP expression (regulated by NCoR and other transcription factors) and on anti‐inflammatory and regenerative genes, leading to an increase in ...
Nicola Davis +8 more
wiley +1 more source
Acta Pharmaceutica Sinica BCoronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart disease. Here, we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum- and PDGF-BB-induced vascular ...
Xiaoxuan Zhong +12 more
doaj +1 more source
The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression
BMC Neuroscience, 2019 Background Histone deacetylase-3 (HDAC3) promotes neurodegeneration in various cell culture and in vivo models of neurodegeneration but the mechanism by which HDAC3 exerts neurotoxicity is not known.
Anto Sam Crosslee Louis Sam Titus +3 more
doaj +1 more source
Abstract Acute kidney injury (AKI) refers to clinical syndromes culminating in sharp reduction in renal function over a short period of time because of various reasons. These syndromes manifest in the form of inflammation and apoptosis of renal tubular epithelial cells via controlled demise. Histone deacetylases are critical in renal physiology
Qi Chen +23 more
openaire +1 more source
Uncovering the interplay between epigenome editing efficiency and sequence context using a novel inducible targeting system [PDF]
, 2018 Epigenome editing is an attractive way to manipulate gene expression. However, editing efficiencies depend on the DNA sequence context in a manner that remains poorly understood.
Aeschbach, Lorene +3 more
core +2 more sources
Broad-spectrum antibiotics disrupt homeostatic efferocytosis [PDF]
The clearance of apoptotic cells, termed efferocytosis, is essential for tissue homeostasisand prevention of autoimmunity1. Although past studies have elucidated local molecular signals that regulate homeostatic efferocytosis in a tissue2,3, whether ...
Anderson, CJ +15 more
core +2 more sources
ROLE OF HISTONE DEACETYLASES IN REGULATION OF MACROPHAGE PHAGOCYTOSIS OF MYCOBACTERIUM TUBERCULOSIS [PDF]
, 2023 Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global health emergency. Macrophages are critical in protection against TB by phagocytosis of Mtb. Although histone deacetylases (HDACs), are critical in macrophage differentiations,
Esiesimua, Benjamin
core +1 more source
Low butyrate concentrations exert anti-inflammatory and high concentrations exert pro-inflammatory effects on macrophages [PDF]
Butyrate is a four-carbon short-chain fatty acid produced from microbial fermentation of dietary fibers present at high millimolar concentrations in the colonic lumen.
Bianchi, Frans +6 more
core +1 more source
Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome [PDF]
Targeting inflammation in atherosclerotic cardiovascular disease (ASCVD) remains a major unmet need. Low-dose interleukin-2 (IL-2LD) selectively increases regulatory T cell (Treg) numbers in patients with coronary artery disease.
core +2 more sources