Results 71 to 80 of about 1,119 (155)

Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Dual HDAC and PARP inhibition restores STING signaling, enhances interferon response, and boosts antitumor immunity in STING‐deficient tumors. . Abstract The stimulator of interferon genes (STING)‐mediated innate immune pathway plays an important role in tumor immunosurveillance.
Chengzhou Mao, Weiwen Fan, Jiaqi Liu, Fangzhou Yang, Wenkai Li, Lulu Li, Zhichao Shi, Qinyuan Li, Zigao Yuan, Yuyang Jiang, Bizhu Chu   +10 more
wiley   +1 more source

Xylanase enhances gut microbiota-derived butyrate to exert immune-protective effects in a histone deacetylase-dependent manner [PDF]

Background Commensal bacteria in the intestine release enzymes to degrade and ferment dietary components, producing beneficial metabolites. However, the regulatory effects of microbial-derived enzymes on the intestinal microbiota composition and the ...
Ding, Feifei, Du, Zhenyu, Galindo-Villegas, Jorge, Hao, Zhenzhen, Su, Xiaoyun, Wang, Tong, Zhang, Meiling, Zhou, Nannan   +7 more
core   +1 more source

The Probiotic Parabacteroides johnsonii Ameliorates Metabolic Disorders Through Promoting BCAAs to BSCFAs Conversion

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Clinical discovery and the proposed underlying mechanism by how P. johnsonii ameliorated metabolic disorders. Abstract The gut bacterium Parabacteroides spp. is increasingly recognized for its therapeutic potential in treating metabolic disorders. However, the role of Parabacteroides johnsonii in metabolic disorders is never reported.
Yimeng Chen, Shujun Jiang, Haolu Wang, Mengzhen Si, Haixia Wu, Xinyi Liang, Shenmeng Yao, Yanliang Zhang, Xiaodong Wen, Jie Yang   +9 more
wiley   +1 more source

Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections [PDF]

Innate immunity plays an important role in host defense against pathogenic infections. It involves macrophage polarization into either the pro-inflammatory M1 or the anti-inflammatory M2 phenotype, influencing immune stimulation or suppression ...
Bhat, Mohammad Faizan, Dekker, Frank J, Einarsdóttir, Helga Kristín, Marjomäki, Varpu, Srdanović, Sonja, Sundberg, Lotta-Riina   +5 more
core   +1 more source

Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy

Diabetes/Metabolism Research and Reviews, Volume 41, Issue 6, September 2025.
ABSTRACT An increasing number of individuals are at high risk of type 2 diabetes (T2DM) and its cardiovascular (CV) complications, which challenges healthcare systems with an increased risk of developing CV diseases. Patients with T2DM exhibit a unique cardiac phenotype termed diabetic cardiomyopathy (DCM).
Adam Russell‐Hallinan, Narainrit Karuna, Frank Lezoualc'h, Giuseppe Matullo, Hana Baker, Monique Bernard, Yvan Devaux, Lina Badimon, Gemma Vilahur, Jennifer Rieusset, Geneviève A. Derumeaux, Chris J. Watson   +11 more
wiley   +1 more source

DISSECTING THE ROLE OF HISTONE DEACETYLASE 3 (HDAC3) IN LEUKEMOGENESIS [PDF]

, 2016
Histone deacetylases (HDACs) are epigenetic enzymes that modulate chromatin structure through the deacetylation of lysine residues in histones, playing a crucial role in cell viability, cell cycle progression and tumorigenesis. Yet the role of individual
P. Mehdipour
core   +1 more source

Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease

MedComm, Volume 6, Issue 7, July 2025.
Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song, Bin Liu, Haiou Wang, Wei Sun   +3 more
wiley   +1 more source

HDAC3-mediated deacetylation of p21 stabilizes protein levels and promotes 5-FU resistance in colorectal cancer cells

Advances in Cancer Biology - Metastasis
5-Fluorouracil (5-FU) remains a cornerstone in colorectal cancer (CRC) chemotherapy; however, its clinical efficacy is often compromised by the development of resistance. Histone deacetylase 3 (HDAC3) has been implicated in chemoresistance across various
Wei Jin, Jue-jue Wang, Yan-fei Feng, Bing Chen, Zhao-hua Hu   +4 more
doaj   +1 more source

MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells

Disease Models & Mechanisms, 2017
Mutations in the gene encoding emerin cause Emery–Dreifuss muscular dystrophy (EDMD). Emerin is an integral inner nuclear membrane protein and a component of the nuclear lamina. EDMD is characterized by skeletal muscle wasting, cardiac conduction defects
Carol M. Collins, Joseph A. Ellis, James M. Holaska   +2 more
doaj   +1 more source

Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC) [PDF]

, 2020
Histone deacetylases (HDACs) play important roles in inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD). Unravelling of and interfering with the functions of specific isoenzymes contributing to inflammation provides ...
Cao, Fangyuan, Chen, Deng, de Weerd, Sander, Dekker, Frank J, van der Wouden, Petra E, Zwinderman, Martijn R H   +5 more
core   +1 more source