Results 71 to 80 of about 888 (124)

The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3–SRF axis

Acta Pharmaceutica Sinica B
Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart disease. Here, we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum- and PDGF-BB-induced vascular ...
Xiaoxuan Zhong, Xiang Wei, Yan Xu, Xuehai Zhu, Bo Huo, Xian Guo, Gaoke Feng, Zihao Zhang, Xin Feng, Zemin Fang, Yuxuan Luo, Xin Yi, Ding-Sheng Jiang   +12 more
doaj   +1 more source

The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression

BMC Neuroscience, 2019
Background Histone deacetylase-3 (HDAC3) promotes neurodegeneration in various cell culture and in vivo models of neurodegeneration but the mechanism by which HDAC3 exerts neurotoxicity is not known.
Anto Sam Crosslee Louis Sam Titus, Dharmendra Sharma, Min Soo Kim, Santosh R. D’Mello   +3 more
doaj   +1 more source

HDAC3 inhibitor RGFP966 mitigates acute kidney injury by modulating RIPK1-mediated programmed necrosis

Abstract Acute kidney injury (AKI) refers to clinical syndromes culminating in sharp reduction in renal function over a short period of time because of various reasons. These syndromes manifest in the form of inflammation and apoptosis of renal tubular epithelial cells via controlled demise. Histone deacetylases are critical in renal physiology
Qi Chen, Qi Chen, man-man xie, man-man xie, Ying Chen, Ying Chen, run-run shan, run-run shan, ju-tao yu, ju-tao yu, rui hou, rui hou, yu-hang dong, yu-hang dong, xiu-feng luo, xiu-feng luo, Ze-hui Dong, Ze-hui Dong, li gao, li gao, Xiao-ming Meng, Xiao-ming Meng, shao-fei zhang, shao-fei zhang   +23 more
openaire   +1 more source

Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice

Arthritis Research & Therapy
Background Gout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inhibition of Class I Histone deacetylases (HDACs) can significantly reduce MSU crystals-induced inflammation.
Qi-Bin Yang, Meng-Yun Zhang, Liu Yang, Jie Wang, Qing-Sheng Mi, Jing-Guo Zhou   +5 more
doaj   +1 more source

Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury

Journal of Neuroinflammation
Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and central retinal artery and vein occlusions.
Rami A. Shahror, Esraa Shosha, Carol Morris, Melissa Wild, Shengyu Mu, Gabor Csanyi, Marjan Boerma, Nancy J. Rusch, Abdelrahman Y. Fouda   +8 more
doaj   +1 more source

Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation

Cellular & Molecular Biology Letters
Background Stroke is a type of acute brain damage that can lead to a series of serious public health challenges. Demonstrating the molecular mechanism of stroke-related neural cell degeneration could help identify a more efficient treatment for stroke ...
Yuhua Chen, Wei He, Junlin Qiu, Yangyang Luo, Chenlong Jiang, Feng Zhao, Hong Wei, Jiao Meng, Tianlin Long, Xin Zhang, Lingjian Yang, Quanhua Xu, Juning Wang, Chi Zhang   +13 more
doaj   +1 more source

<p>RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro</p>

Drug Design, Development and Therapy, 2020
Xinying Yu, Fan Yang, Hong Jiang, Ling Fan   +3 more
openaire   +2 more sources

Histone decrotonylation plays a distinct role in HIV latency. [PDF]

Sci Adv
Li X, Li D, Tang Y, Nearing M, Varco-Merth B, Chen H, Smith D, Gianella S, Archin NM, Okoye AA, Dandekar S, Margolis DM, Chirasani VR, Gumpper RH, Jiang G.   +14 more
europepmc   +1 more source

HDAC3 Mediates Hippocampal Microglial Pyroptosis Via the STING/NLRP3 Pathway and Contributes To Cognitive Impairment in Sepsis-Associated Encephalopathy. [PDF]

Inflammation
Cai M, Shao H, Xu S, Wang H, Yang MJ, Zhu T, Chen J, Li GZ, Lu SF, Zang YY, Ji MH, Shen JC, Jia M, Yang JJ.   +13 more
europepmc   +1 more source

Pectolinarigenin Attenuates LPS-Induced Lung Inflammation and Injury with Reduced HDAC3/NF-κB/NLRP3 Signaling. [PDF]

Antioxidants (Basel)
Kim D, Lee DK, Park JR.
europepmc   +1 more source