Results 111 to 120 of about 888 (124)

RGFP966, a selective HDAC3 inhibitor, ameliorates allergic and inflammatory responses in an OVA-induced allergic rhinitis mouse model

International Immunopharmacology, 2021
RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3) playing crucial roles in triggering allergic and inflammatory responses. Whereas, its role in allergic rhinitis (AR) remains uncertain. This study sought to illustrate the role and mechanism of HDAC3 inhibitor RGFP966 on allergic and inflammatory responses in murine AR.
Hai Lin, Tang Ru, Guangyi Ba
exaly   +3 more sources

Histone deacetylase 3-selective inhibitor RGFP966 ameliorates impaired glucose tolerance through β-cell protection

Toxicology and Applied Pharmacology, 2020
The potential therapeutic effect of histone deacetylase 3 (HDAC3) pharmacologic inhibition on diabetes has been focused recently. RGFP966, as a highly-selective HDAC3 inhibitor, its possible roles and underlying mechanism in the treatment of diabetes needs to be clarified. In this study, low-dose streptozotocin (STZ)-induced pre-diabetic mice were used
Yi Huan, Shuainan Liu, Jie Xia
exaly   +3 more sources

3D printing of nerve conduits with nanoparticle-encapsulated RGFP966

Applied Materials Today, 2019
Abstract Nerve conduits have great promise for bridging peripheral nerve defects that always cause disability. Currently, the clinically used nerve conduits are limited in promoting nerve regeneration, leading to the unsatisfied nerve repair efficiency.
Jie Tao, Jianguo Xu, Long Jianlin
exaly   +2 more sources

HDAC3 Inhibitor RGFP966 Ameliorated Neuroinflammation in the Cuprizone-Induced Demyelinating Mouse Model and LPS-Stimulated BV2 Cells by Downregulating the P2X7R/STAT3/NF-κB65/NLRP3 Activation

ACS Chemical Neuroscience, 2022
Suppression of excessive microglial overactivation can prevent the progression of multiple sclerosis (MS). Histone deacetylases 3 inhibitor (HDAC3i) has been demonstrated to exert anti-inflammatory effects by suppressing microglia (M1-liked) activation.
Min Wen, Ning Zhang, Ruiyan Zhang
exaly   +3 more sources

RGFP966 inhibits palmitic acid induced VSMCs phenotypic transition by targeting ATGL

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids
The phenotypic switch of vascular smooth muscle cells (VSMCs) underlies the pathology of many cardiovascular diseases. Histone deacetylase 3 (HDAC3) is reported to upregulate in several cardiovascular diseases. RGFP966 is a highly selective HDAC3 inhibitor.
Ren Guo, Youjie Zeng
exaly   +3 more sources

Effect of RGFP966 application in key steps of sheep somatic cell nuclear transfer on cloned embryo development

Animal Reproduction Science
This study explored the effect and mechanism of the histone deacetylase 3 (HDAC3)-selective inhibitor (E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide (RGFP966) in optimizing key steps of sheep somatic cell nuclear transfer (SCNT).
Hongyuan, Song, Zhipeng, Qi, Junli, He, Yujie, Yan, Jinghua, Wang, Sirui, Min, Qiang, Chen, Xinfeng, Liu   +7 more
exaly   +3 more sources

Inhibition of histone deacetylase 3 via RGFP966 facilitates cortical plasticity underlying unusually accurate auditory associative cue memory for excitatory and inhibitory cue-reward associations

Behavioural Brain Research, 2019
Epigenetic mechanisms are key for regulating long-term memory (LTM) and are known to exert control on memory formation in multiple systems of the adult brain, including the sensory cortex. One epigenetic mechanism is chromatin modification by histone acetylation. Blocking the action of histone de-acetylases (HDACs) that normally negatively regulate LTM
Kasia Bieszczad, Andrea Shang
exaly   +3 more sources

RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7

Biochemical Pharmacology, 2020
Glioma stem cells (GSC) play a major role in drug resistance and tumor recurrence. Using a genetic screen with a set of shRNAs that can target chromatin regulators in a GSC model, we have HDAC3 as a major negative regulator of GSC differentiation.
Hang, Liang, Qian, Wang, Ding, Wang, Hongwu, Zheng, Dhan V, Kalvakolanu, Hua, Lu, Naiyan, Wen, Xuyang, Chen, Libo, Xu, Jiaxin, Ren, Baofeng, Guo, Ling, Zhang   +11 more
openaire   +2 more sources

Inhibition of histone deacetylase 3 via RGFP966 facilitates unusually accurate cue memory for excitatory and inhibitory cue-reward associations

2018
Epigenetic mechanisms are key for regulating long-term memory (LTM) and are known to exert control on memory formation in multiple systems of the adult brain, including the sensory cortex. One epigenetic mechanism is chromatin modification by histone acetylation. Blocking the action of histone de-acetylases (HDACs) that normally negatively regulate LTM
Bieszczad, Kasia M., Shang, Andrea, Bylipudi, Sooraz   +2 more
openaire   +1 more source

HDAC3 inhibitor RGFP966 acts on the NF-kB pathway and enhances memory persistence in a biphasic manner

Abstract Nearly five decades ago, it was first observed that long-term memory consolidation requires waves of transcriptional activity and protein synthesis, with the first two waves occurring within hours after learning.
Agustina Robles, Santiago D’hers, Mariana Feld, Arturo Romano   +3 more
openaire   +1 more source