Results 11 to 20 of about 888 (124)

Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation [PDF]

Journal of Neuroscience, 2015
Research over the past decade indicates a novel role for epigenetic mechanisms in memory formation. Of particular interest is chromatin modification by histone deacetylases (HDACs), which, in general, negatively regulate transcription. HDAC deletion or inhibition facilitates transcription during memory consolidation and enhances long-lasting forms of ...
Kasia Bieszczad, Kirollos Raouf Bechay, Marcelo Wood   +2 more
exaly   +5 more sources

Molecular modeling to simulation: insights into Gaussian QSAR, molecular docking, and DFT for identification of HDAC3 inhibitors for neurocognitive vascular dementia [PDF]

Scientific Reports
Vascular dementia is the second most common form of dementia. It is characterized by reduced blood flow in the cerebral cortex due to neurodegeneration and neuroinflammation. Almost 10 crore people will be suffering from it by 2030.
Debojyoti Halder, Suvankar Banerjee, Swati Biswas, Nilanjan Adhikari, Balaram Ghosh   +4 more
doaj   +2 more sources

Microglial HDAC3 inhibits the migration of CD8-positive T cell in the development of EAE by restraining the expression of CCL5 [PDF]

Cell & Bioscience
Background Multiple sclerosis (MS) is a central nervous system disease caused by auto-immune reaction induced demyelination, however, the molecular mechanism of MS remains unclear. Previous study revealed that histone deacetylase 3 (HDAC3) is upregulated
Na Che, Yang Zhang, Bo Wang, Hongxing Wu, Zhiqiong Mao, Zengqiang Yuan, Xiangxi Kong, Yajin Liao   +7 more
doaj   +2 more sources

HDAC3 inhibitors induce drug resistance by promoting IL-17 A production by T cells [PDF]

Scientific Reports
HDAC3 has been demonstrated to play a crucial role in the progression of various tumors and the differentiation and development of T cells. However, its impact on peripheral T cells in the development of murine lung cancer remains unclear.
Hao Chen, Anqi Qin, Fan Xu, Shuai Guo, Ge Zhang, Aihong Zhang, WenTing Li, Feng Tian, Quanhui Zheng   +8 more
doaj   +2 more sources

Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Histone deacetylase 3 (HDAC3) can acetylate histones, negatively regulating Neuronal Per-Arnt-Sim domain protein 4 (Npas4) and participating in various pathological processes of central nervous system lesions.
Haiping Gu, Yating Gong, Muyao Wu, Mengying Shi, Jiejie Yu, Hongfei Zhu, Ya-ming Sun, Baoqi Dang   +7 more
doaj   +2 more sources

HDAC3 represses Nrf2-GDF11 signaling to drive chondrocyte adipogenesis in temporomandibular joint osteoarthritis [PDF]

Journal of Advanced Research
Introduction: Aberrant biomechanical force-induced chondrocyte adipogenesis is involved in the development of temporomandibular joint osteoarthritis (TMJ OA). Growth differentiation factor 11 (GDF11) has been implicated in this process.
Yuqian Shi, Zhihua Xu, Fuyin Li, Qian Liu, Ying Zhan, Fan Wu, Qinghua Li, Fa He, Peinan Fan, Hongyun Zhang, Shibin Yu, Feng He, Helin Wang, Mian Zhang   +13 more
doaj   +2 more sources

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

Biochemical Pharmacology, 2016
The increasing number of patients suffering from chronic obstructive pulmonary disease (COPD) represents a major and increasing health problem. Therefore, novel therapeutic approaches are needed. Class I HDACs 1, 2 and 3 play key roles in the regulation of inflammatory gene expression with a particular pro-inflammatory role for HDAC 3.
Frank Dekker, Rainer Bischoff, Wouter Hooghiemstra   +2 more
exaly   +4 more sources

Inhibition of histone deacetylases 3 attenuates imiquimod-induced psoriatic dermatitis via targeting cGAS-STING signaling in keratinocytes [PDF]

Journal of Translational Medicine
Background Psoriasis is a common chronic inflammatory skin disease characterized by epidermal keratinocyte hyperproliferation and persistent immune activation.
Chong Zeng, Xiujuan Wen, Zibo Wei, Xinhuai Dong   +3 more
doaj   +2 more sources

Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway [PDF]

Journal of Advanced Research
Introduction: Kaempferol (KAE) is a flavonoid found in various plants. Recent studies showed that high dietary intake of KAE was associated with a lower risk of myocardial infarction; however, the cardioprotective mechanism of KAE remains unknown ...
Zejun Yue, Yirong Zhang, Wei Zhang, Nanbo Zheng, Jiazheng Wen, Lingxuan Ren, Xiaoyu Rong, Liang Bai, Rong Wang, Sihai Zhao, Enqi Liu, Weirong Wang   +11 more
doaj   +2 more sources

FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulation [PDF]

Journal of Neuroinflammation
Background Persistent neuroinflammation and synaptic dysregulation in the spinal dorsal horn (SDH) has been well-established as a critical mechanism contributing to neuropathic pain (NP). Microglia play a pivotal role in modulating both neuroinflammatory
Hui Zeng, Bo Wang, ZhiLin Huang, LiJie Gao, Yao Xiao, XinLi Liu, Yin Xu, ZiWei Hu, JiaHui Pang, YouXin Yu, YanWu Guo, Wen Wu   +11 more
doaj   +2 more sources