Results 11 to 20 of about 1,119 (155)

RGFP966 exerts neuroprotective effect via HDAC3/Nrf2 pathway after surgical brain injury in rats

Heliyon, 2023
Background: Histone deacetylase 3 (HDAC3) restores chromatin nucleosomes to a transcriptional repression state, thereby inhibiting gene expression. Studies have found that HDAC3 expression is upregulated in a variety of pathological states of the central
Hai-Ping Gu, Xiao-Feng Wu, Ya-Ting Gong, Mu-Yao Wu, Meng-Ying Shi, Ya-ming Sun, Bao-Qi Dang, Gang Chen   +7 more
doaj   +3 more sources

HDAC3 Inhibitor RGFP966 Modulates Neuronal Memory for Vocal Communication Signals in a Songbird Model [PDF]

Frontiers in Systems Neuroscience, 2017
Epigenetic mechanisms that modify chromatin conformation have recently been under investigation for their contributions to learning and the formation of memory. For example, the role of enzymes involved in histone acetylation are studied in the formation
Mimi L. Phan, Mark M. Gergues, Shafali Mahidadia, Jorge Jimenez-Castillo, David S. Vicario, Kasia M. Bieszczad   +5 more
doaj   +3 more sources

Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation [PDF]

The Journal of Neuroscience, 2015
Research over the past decade indicates a novel role for epigenetic mechanisms in memory formation. Of particular interest is chromatin modification by histone deacetylases (HDACs), which, in general, negatively regulate transcription.
Bechay, Kiro, Bieszczad, Kasia M., Jacques, Vincent, Kudugunti, Shashi, McGaugh, James L., Miao, Wenyan, Rusche, James R., Weinberger, Norman M., Wood, Marcelo A.   +8 more
core   +6 more sources

RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro

Drug Design, Development and Therapy, 2020
Xinying Yu, 1 Fan Yang, 2 Hong Jiang, 3 Ling Fan 1 1Second Pediatric Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China; 2Third Neonatal Ward, Shengjing Hospital of ...
Yu X, Yang F, Jiang H, Fan L
doaj   +3 more sources

Unraveling the role of HDAC3 as an immunotherapy prognostic biomarker and therapeutic target in advanced non-small cell lung cancer [PDF]

Respiratory Research
Background This study investigates HDAC3 as a potential immunotherapy biomarker in advanced non-small cell lung cancer (aNSCLC), focusing on its association with treatment response to immune checkpoint inhibitors (ICIs). Methods We employed a multi-phase
Liyuan Dai, Liling Huang, Lin Li, Le Tang, Yuankai Shi, Xiaohong Han   +5 more
doaj   +2 more sources

FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulation [PDF]

Journal of Neuroinflammation
Background Persistent neuroinflammation and synaptic dysregulation in the spinal dorsal horn (SDH) has been well-established as a critical mechanism contributing to neuropathic pain (NP). Microglia play a pivotal role in modulating both neuroinflammatory
Hui Zeng, Bo Wang, ZhiLin Huang, LiJie Gao, Yao Xiao, XinLi Liu, Yin Xu, ZiWei Hu, JiaHui Pang, YouXin Yu, YanWu Guo, Wen Wu   +11 more
doaj   +2 more sources

Epigenetic Suppression of RASAL1 by HDAC3 and Cofactor YY1 Promotes Fibroblast–Myofibroblast Transition and Renal Fibrosis [PDF]

Research
Fibroblast–myofibroblast transition (FMT) and the resultant renal fibrosis are central pathological features of chronic kidney disease (CKD). Epigenetic suppression of RASAL1 (Ras protein activator like 1), an antifibrotic regulator in fibroblasts, is a ...
Fang Chen, Lijun Zhang, Weiying Liu, Bingbing Zhang, Shuren Wang, Zhengdong Zhou, Wei Wang, Jiansong Shen, Yijun Deng, Wangsen Cao   +9 more
doaj   +2 more sources

Structure-based screening of FDA-approved drugs identifies potential histone deacetylase 3 repurposed inhibitor: molecular docking and molecular dynamic simulation approaches. [PDF]

Front Pharmacol
Histone deacetylase 3 (HDAC3) is a member of the histone deacetylase family that has emerged as a crucial target in the quest for novel therapeutic interventions against various complex diseases, including cancer.
Shamsi A, Khan MS, Yadav DK, Shahwan M.
europepmc   +3 more sources

Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice [PDF]

Arthritis Research & Therapy
Background Gout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inhibition of Class I Histone deacetylases (HDACs) can significantly reduce MSU crystals-induced inflammation.
Qi-Bin Yang, Meng-Yun Zhang, Liu Yang, Jie Wang, Qing-Sheng Mi, Jing-Guo Zhou   +5 more
doaj   +2 more sources

Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation [PDF]

Cellular & Molecular Biology Letters
Background Stroke is a type of acute brain damage that can lead to a series of serious public health challenges. Demonstrating the molecular mechanism of stroke-related neural cell degeneration could help identify a more efficient treatment for stroke ...
Yuhua Chen, Wei He, Junlin Qiu, Yangyang Luo, Chenlong Jiang, Feng Zhao, Hong Wei, Jiao Meng, Tianlin Long, Xin Zhang, Lingjian Yang, Quanhua Xu, Juning Wang, Chi Zhang   +13 more
doaj   +2 more sources