Results 101 to 110 of about 3,215 (191)

Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly.

PLoS ONE, 2013
To find histone deacetylase 3 (HDAC3)-selective inhibitors, a series of 504 candidates was assembled using "click chemistry", by reacting nine alkynes bearing a zinc-binding group with 56 azide building blocks in the presence of Cu(I) catalyst. Screening
Takayoshi Suzuki, Yuki Kasuya, Yukihiro Itoh, Yosuke Ota, Peng Zhan, Kaori Asamitsu, Hidehiko Nakagawa, Takashi Okamoto, Naoki Miyata   +8 more
doaj   +1 more source

Involvement of Hdac3-mediated inhibition of microRNA cluster 17-92 in bronchopulmonary dysplasia development

Molecular Medicine, 2020
Background The incidence of bronchopulmonary dysplasia (BPD), a chronic lung disease of newborns, has been paradoxically rising despite medical advances. Histone deacetylase 3 (Hdac3) has been reported to be a crucial regulator in alveologenesis.
Di Wang, Hui Hong, Xiao-Xia Li, Jing Li, Zhi-Qun Zhang   +4 more
doaj   +1 more source

Empirical PK/PD Model for Differentiating Intrinsic Dosing Rules by Therapeutic Indication With Relevance for HIV‐1 Latency Reversal

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1414-1426, November 2026.
Romidepsin (RMD), an FDA‐approved histone deacetylase inhibitor for treating cancer, demonstrates potent latency‐reversing activity in vitro but has yielded suboptimal outcomes in kick‐and‐kill HIV‐cure trials when administered as a 5 mg/m2 infusion.
Lauren A. R. Tompkins, Amanda Poliseno, Airlie Ward, Edward P. Browne, Cassandra Gilbert, Craig Sykes, Angela D. M. Kashuba, Mackenzie L. Cottrell   +7 more
wiley   +1 more source

The role of HDAC3-interacting protein Pink1 in oxidative stress-mediated neuronal cell death

, 2010
Dept. of Medical Science/박사[한글] [영문]Even though histone deacetylase 3 (HDAC3) is shown to affect gene expression via the regulation of acetylation of histone substrates, the role of HDAC3 in well signaling is not well known. To further investigate the
강희범
core  

HDAC4 interacts with both the MR and HDAC3.

, 2015
A, HEK293 cells were transfected with MR-HA and either HDAC4-Flag, HDAC5-Flag, or HDAC7-Flag plasmids. After 48 h, the cells were treated with Aldo (10 nM) for 30 min. Whole-cell lysates (WCLs) were prepared with non-denaturing lysis buffer.
Sang-Yeob Kim (317878), Young-Mi Seok (787355), Seol-Hee Kang (787356), Hae-Ahm Lee (787353), Min-Ji Song (787354), Inkyeom Kim (787357)   +5 more
core   +1 more source

BDH1 Attenuates Macrophage Foam Cell Formation and Inflammation in Atherosclerosis Via Modulating Histone H3K9 Acylation Balance and Activating PPAR Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In atherosclerotic lesions, BDH1 expression is downregulated in plaque macrophages. In ox‐LDL‐induced RAW264.7 macrophages, BDH1 overexpression maintains H3K9 acylation homeostasis by upregulating H3K9ac and downregulating H3K9bhb, thereby increasing cell viability, reducing lipid accumulation, decreasing TNF‐α, and increasing IL‐10.
Yu Wang, Yi Wang, Qinghong Liu, Mao Tian, Bin Wang, Qiang Lin, Shuiying Huang   +6 more
wiley   +1 more source

Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source

Applying Proteogenomics to Characterize Molecular Features Associated With a High‐Risk HOXB13 Gene Variant in Prostate Cancer Tumors

MedComm, Volume 7, Issue 11, November 2026.
Prostate tumors from six heterozygous G84E variant carriers (G84E positive) and 18 non‐carriers (wild‐type) were examined using the Human AmpliSeq Transcriptome Gene Expression Panel, and proteomes were generated by mass spectrometry (SWATH). We identified a 799‐gene expression profile and a 75‐protein expression profile in G84E‐positive tumors when ...
Kelsie Raspin, Zainab Noor, Adel T. Aref, James R. Marthick, Chol‐hee Jung, Shaun Donovan, Steve Williams, Peter G. Hains, Phillip J. Robinson, Rosemary L. Balleine, Qing Zhong, Roger R. Reddel, Liesel M. FitzGerald, Joanne L. Dickinson   +13 more
wiley   +1 more source

Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury

Journal of Neuroinflammation
Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and central retinal artery and vein occlusions.
Rami A. Shahror, Esraa Shosha, Carol Morris, Melissa Wild, Shengyu Mu, Gabor Csanyi, Marjan Boerma, Nancy J. Rusch, Abdelrahman Y. Fouda   +8 more
doaj   +1 more source

HDAC3 promotes meiotic apparatus assembly in mouse oocytes via modulating tubulin acetylation

, 2017
Histone deacetylases (HDACs) have been shown to deacetylate numerous cellular substrates that govern a wide array of biological processes. HDAC3, a member of the Class I HDACs, is a highly conserved and ubiquitously expressed protein.
Haichao Wang, Bo Xiong, Longsen Han, Xiaohui Liu, Danhong Qiu, Ling Gu, Min Gao, Xiaoyan Li, Shao-Chen Sun, Honglin Liu   +9 more
core   +1 more source