Results 101 to 110 of about 18,122 (224)

Dichotomous Engagement of HDAC3 Catalytic Activity Governs Inflammatory Responses [PDF]

, 2020
Mammalian gene expression is activated by histone acetylation, which is reversed by histone deacetylases (HDACs) whose enzymatic functions are pharmaceutically targeted by HDAC inhibitors for cancer treatment and many other diseases.
Bui Nguyen, Hoang Chuong, Nguyen, Hoang C. B   +1 more
core  

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

EMBO Molecular Medicine, 2018
AKT‐mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other.
Yuqian Yan, Jian An, Yinhui Yang, Di Wu, Yang Bai, William Cao, Linlin Ma, Junhui Chen, Zhendong Yu, Yundong He, Xin Jin, Yunqian Pan, Tao Ma, Shangqian Wang, Xiaonan Hou, Saravut John Weroha, R Jeffrey Karnes, Jun Zhang, Jennifer J Westendorf, Liguo Wang, Yu Chen, Wanhai Xu, Runzhi Zhu, Dejie Wang, Haojie Huang   +24 more
doaj   +1 more source

Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination

Cell Reports, 2018
Summary: Primordial germ cells (PGCs) are fate determined from pluripotent epiblasts. Signaling pathways and transcriptional regulators involved in PGC formation have been identified, but detailed molecular mechanisms of PGC fate determination remains ...
Kentaro Mochizuki, Yohei Hayashi, Tamotsu Sekinaka, Kei Otsuka, Yumi Ito-Matsuoka, Hisato Kobayashi, Shinya Oki, Asuka Takehara, Tomohiro Kono, Noriko Osumi, Yasuhisa Matsui   +10 more
doaj   +1 more source

Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria

Cancer Science, EarlyView.
Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng   +11 more
wiley   +1 more source

Histone Deacetylase 3 (HDAC3) Activity is Regulated by Interaction with Protein Serine/Threonine Phosphatase 4

, 2010
[[abstract]]Histone deacetylase 3 (HDAC3) is one of four members of the human class I HDACs that regulates gene expression by deacetylation of histones and nonhistone proteins.
Zhang X; Ozawa Y; Lee H; Wen YD; Tan TH; Wadzinski BE; Seto E
core  

Role of HDAC3 in the epithelial-mesenchymal transition of retinal pigment epithelium cells: Implications for proliferative vitreoretinopathy

Heliyon
Proliferative vitreoretinopathy(PVR) is a type of fibrotic eye disease with a poor clinical prognosis. Increasing evidence has shown that the primary pathological mechanism of PVR is the epithelial-mesenchymal transition(EMT) of retinal pigment ...
Weikang Zou, Chunling Huang, Yuting Chen, Jing Tang, Qiqi Li, Qi Fang, Yulin Ma, Wei Wu, Songfu Feng   +8 more
doaj   +1 more source

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

EMBO Molecular Medicine, 2014
Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management.
Marten A Hoeksema, Marion JJ Gijbels, Jan Van den Bossche, Saskia van der Velden, Ayestha Sijm, Annette E Neele, Tom Seijkens, J Lauran Stöger, Svenja Meiler, Marieke CS Boshuizen, Geesje M Dallinga‐Thie, Johannes HM Levels, Louis Boon, Shannon E Mullican, Nathanael J Spann, Jack P Cleutjens, Chris K Glass, Mitchell A Lazar, Carlie JM de Vries, Erik AL Biessen, Mat JAP Daemen, Esther Lutgens, Menno PJ de Winther   +22 more
doaj   +1 more source

HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

Journal of Neuroinflammation, 2019
Background Type 2 diabetes mellitus (T2DM) is a chronic metabolic dysfunction characterized by progressive insulin resistance and hyperglycaemia. Increased blood-brain barrier (BBB) permeability is a critical neurovascular complication of T2DM that ...
Qiuchen Zhao, Fang Zhang, Zhanyang Yu, Shuzhen Guo, Ning Liu, Yinghua Jiang, Eng H. Lo, Yun Xu, Xiaoying Wang   +8 more
doaj   +1 more source

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source