Results 61 to 70 of about 18,122 (224)
Cell & Bioscience, 2022 Background As important enzymes regulating acetylation, histone deacetylases (HDACs) participate in a series of cell physiological process. However, the mechanisms responsible for individual HDAC family members in regulating innate immunity remained to ...
Liping Yang +10 more
doaj +1 more source
Romanian Journal of Laboratory MedicineAtopic dermatitis (AD) is a chronic immune and inflammatory dermatologic disease. Preclinical and clinical studies have indicated that stem cell transplantation is considered an alternative treatment option for ameliorating the symptoms of AD.
Wu ZhengPing +9 more
doaj +1 more source
PLoS ONE, 2010 Histone deacetylase (Hdac)3 is a nuclear enzyme that contributes to epigenetic programming and is required for embryonic development. To determine the role of Hdac3 in bone formation, we crossed mice harboring loxP sites around exon 7 of Hdac3 with mice ...
David F Razidlo +9 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
NudC associates with HDAC3 in mitosis and a loss of HDAC3 increases NudC acetylation.
, 2013 (A) Cell cycle synchronization schematic. (B) Whole cell lysates (10 µg) from S, G2, early mitosis (prometaphase-like; P), late mitosis (anaphase and telophase; A), and G1 cell cycle phases are blotted with antibodies as indicated.
David H. Hawke (460602) +4 more
core +1 more source
Microbiota-derived metabolite promotes HDAC3 activity in the gut [PDF]
Nature, 2020 The coevolution of mammalian hosts and their beneficial commensal microbes has led to development of symbiotic host-microbiota relationships1. Epigenetic machinery permits mammalian cells to integrate environmental signals2; however, how these pathways are fine-tuned by diverse cues from commensal bacteria is not well understood.
Shu-en Wu +9 more
openaire +2 more sources
Drug Design, Development and Therapy, 2020 Xinying Yu, 1 Fan Yang, 2 Hong Jiang, 3 Ling Fan 1 1Second Pediatric Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China; 2Third Neonatal Ward, Shengjing Hospital of ...
Yu X, Yang F, Jiang H, Fan L
doaj
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Hdac3 mRNA and protein expression in Hdac3+/− heterozygous mouse brain.
, 2012 (A) Hdac3 mRNA expression levels in 15 week old mouse cortex, cerebellum and striatum are shown as a relative expression ratio to the WT level. Hdac3+/− (red) and Dbl (purple) mice express the mRNA at 50% of the WT (blue) and R6/2 (green) levels in all ...
Gillian P. Bates (135712) +4 more
core +1 more source
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate [PDF]
Nature, 2012 Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate gene expression by removing acetyl groups from lysine residues in histone tails, resulting in chromatin condensation. The enzymatic activity of most class I HDACs requires recruitment into multi-subunit co-repressor complexes, which are in turn recruited to chromatin by
Watson, PJ +3 more
openaire +3 more sources