Results 61 to 70 of about 3,215 (191)
PLoS ONE, 2009 TR2 is an orphan nuclear receptor specifically expressed in early embryos (Wei and Hsu, 1994), and a transcription factor for transcriptional regulation of important genes in stem cells including the gate keeper Oct4 (Park et al. 2007). TR2 is known to function as an activator (Wei et al.
Pawan Gupta +4 more
openaire +4 more sources
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16
, 2018 It has been reported that class I histone deacetylase (HDAC) inhibition increases thermogenesis in fat, but adipocyte-specific Hdac3 deletions have presented inconsistent results.
Jun Wu +6 more
core +1 more source
eLife, 2019 CD4 and CD8 T cells are vital components of the immune system. We found that histone deacetylase 3 (HDAC3) is critical for the development of CD4 T cells, as HDAC3-deficient DP thymocytes generate only CD8SP thymocytes in mice.
Rachael Laura Philips +8 more
doaj +1 more source
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas [PDF]
, 2017 Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates the development of germinal center (GC)-derived lymphomas in mice.
Hatzi, Katerina +30 more
core +1 more source
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Advanced Science, EarlyView.Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley +1 more source
Cancer Cell International, 2022 Background Deacetylation of histones by histone deacetylase 3 (HDAC3) acts importantly in modulating apoptosis, DNA damage and cellular progression. Herein, we aimed to unravel the functional role of HDAC3 in a lethal disease, esophageal squamous cell ...
Yang Yang +8 more
doaj +1 more source
Advanced Science, EarlyView.In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei +18 more
wiley +1 more source
The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation [PDF]
Frontiers in Immunology, 2015 We previously reported the anti-allergic effect of high molecular weight form of hyaluronic acid (HMW-HA). In doing so, HA targets CD44 and inhibits FcεRI signaling and cross-talk between epidermal growth factor receptor (EGFR) and FcεRI. We previously reported the role of histone deacetylases (HDACs) in allergic inflammation and allergic inflammation ...
Kim, Youngmi +4 more
openaire +3 more sources
S424 Phosphorylation of HDAC3 promotes its binding with PGK1.
, 2015 (A) HDAC3 knockdown prevents the effect of insulin on changing PGK1 K220 acetylation and enzyme activity. HEK293T cells were transiently transfected with siRNAs against HDAC3.
Dan Ye (180080) +14 more
core +1 more source