Results 31 to 40 of about 3,215 (191)

Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease

Translational Neuroscience, 2020
Amyloid-beta (Aβ) plaque deposits and neurofibrillary tangles containing tau proteins are the key pathognomonic manifestations of Alzheimer’s disease (AD). Lack of holistic drugs for AD has reinvigorated enthusiasm in the natural product-based therapies.
Li Zhengyu, Gan Li, Yan Si, Yan Yufang, Huang Wei   +4 more
doaj   +1 more source

Interactions among STAT3, HDAC3 and PP2A [PDF]

, 2009
Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors, and has been reported to be involved in the pathogenesis of various human ...
Ikeda, Osamu, Togi, Sumihito, Matsuda, Tadashi, Kawakami, Shiho, Muromoto, Ryuta, Kamitani, Shinya, Nanbo, Asuka   +6 more
core   +1 more source

The Nuclear Envelope Protein Emerin Binds Directly to Histone Deacetylase 3 (HDAC3) and Activates HDAC3 Activity [PDF]

Journal of Biological Chemistry, 2012
Organization of the genome is critical for maintaining cell-specific gene expression, ensuring proper cell function. It is well established that the nuclear lamina preferentially associates with repressed chromatin. However, the molecular mechanisms underlying repressive chromatin formation and maintenance at the nuclear lamina remain poorly understood.
Justin, Demmerle, Adam J, Koch, James M, Holaska   +2 more
openaire   +2 more sources

Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors [PDF]

Pharmaceuticals, 2014
Histone deacetylases (HDACs) enzymes, which affect the acetylation status of histones and other important cellular proteins, have been recognized as potentially useful therapeutic targets for a broad range of human disorders. Emerging studies have demonstrated that different types of HDAC inhibitors show beneficial effects in various experimental ...
openaire   +3 more sources

HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1 [PDF]

Journal of Biological Chemistry, 2010
HDAC3 is a member of the class I histone deacetylase family that regulates gene expression by deacetylation of histones and non-histone proteins. HDAC3 activity has been shown to be modulated by interaction with the co-repressors NCoR and SMRT. Here, we present evidence that the nuclear protein DBC1 is an endogenous inhibitor of HDAC3.
Claudia C S, Chini, Carlos, Escande, Veronica, Nin, Eduardo N, Chini   +3 more
openaire   +2 more sources

The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

Cell Death and Disease, 2021
Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and ...
Li Ning, Xiong Rui, Wang Bo, Geng Qing
doaj   +1 more source

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity [PDF]

, 2019
Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulating lipid metabolism in the intestinal epithelium is unknown.
Yoganantharaja, P, P Yoganantharaja (13522528), Mariadason, JM, Sylvia Gong (9477659), Hina Kalra (293466), Montgomery, MK, P Ioannidis (12552856), Tögel, L, Lesmana, A, Cameron Scott (9489575), Irvin Ng (9497120), H Anderton (13441347), Al-Obaidi, S, Mathivanan, S, Watt, MJ, Keerthikumar, S, John Mariadason (9487703), Lars Togel (15008484), Scott, CM, K Bell-Anderson (13522531), Reehorst, CM, Hiebert, S, Scott, AM, Analia Lesmana (15003030), Suresh Mathivanan (9487679), David Williams (9477638), Angela Rigopoulos (9491939), Ioannidis, P, Rebecca Nightingale (9498848), S Al-Obaidi (13425828), Shivakumar Keerthikumar (9484178), Dávalos-Salas, M, Y Gibert (13309161), Mercedes Davalos Salas (15474461), Ng, I, Rigopoulos, A, Gong, SJ, Gibert, Y, Camilla Marstrander Reehorst (9486830), MJ Watt (14471454), S Hiebert (13522534), Andrew Scott (9483443), Nightingale, R, Williams, DS, Anderton, H, Kalra, H, Bell-Anderson, K, MK Montgomery (14471433)   +47 more
core   +2 more sources

20191109 LC3 HDAC3 manuscript_sup.ppt

, 2020
the potential role of LC3B and HDAC3 in hepatic lipid accumulation in both in vivo and in vitro ...
Yuan-Xiang Pan (8025575)
core   +1 more source

Hdac3 deletion in myeloid progenitor cells enhances bone healing in females and limits osteoclast fusion via Pmepa1

Scientific Reports, 2020
Previous studies examining the role of the histone deacetylase Hdac3 within myeloid cells demonstrated that Hdac3 promotes M2 activation and tissue healing in inflammatory conditions. Since myeloid lineage cells are required for proper bone formation and
David H. H. Molstad, Elizabeth Zars, Andrew Norton, Kim C. Mansky, Jennifer J. Westendorf, Elizabeth W. Bradley   +5 more
doaj   +1 more source

Dynamic monitoring of cognitive impairment and prognostic recurrence risk in patients with stroke by serum HDAC3 and FOXO1: A potential diagnostic approach [PDF]

Journal of Medical Biochemistry
Background: To evaluate the clinical value of dynamically monitoring serum histone deacetylase 3 (HDAC3) and forkhead box protein O1 (FOXO1) levels in evaluating cognitive impairment (CI) in cerebral stroke (CS) patients, to enable early identification ...
Liu Xintong, Wang Lulu, Xiao Bin, Liu Zhengkun, Dou Yue   +4 more
doaj   +1 more source