Results 31 to 40 of about 18,122 (224)

HDAC3

, 2023
The histone deacetylase HDAC3 is associated with the NCoR/SMRT co-repressor complex, and its canonical function is in transcriptional repression, but it can also activate transcription.
Lei Xu, Sergey Belikov, Wu, Hongmei, Xuewen Liu, Magda Bienko, Bienko, Magda, Shilkova, Olga,, Mattias Mannervik, Olga Shilkova, Tang, Min,, Liu, Xuewen, Belikov, Sergey,, Xu, Lei, Mannervik, Mattias,, Regadas, Isabel,, Hongmei Wu, Min Tang, Isabel Regadas, Erik Wernersson, Wernersson, Erik   +19 more
core   +1 more source

HDAC3 and the molecular brake pad hypothesis [PDF]

Neurobiology of Learning and Memory, 2011
Successful transcription of specific genes required for long-term memory processes involves the orchestrated effort of not only transcription factors, but also very specific enzymatic protein complexes that modify chromatin structure. Chromatin modification has been identified as a pivotal molecular mechanism underlying certain forms of synaptic ...
Susan C, McQuown, Marcelo A, Wood
openaire   +2 more sources

HDAC3 at the Fulcrum of an Epithelial-Mesenchymal Balance [PDF]

Molecular Cell, 2011
In this issue of Molecular Cell, Wu et al. (2011) reveal an essential role for a chromatin modifier, histone deacetylase 3 (HDAC3), in hypoxia-induced epithelial-mesenchymal transition (EMT); HIF-activated HDAC3 integrates with WDR5 to impose chromatin modifications that culminate in EMT.
Mani, Sendurai A., Barton, Michelle Craig   +1 more
openaire   +2 more sources

Endocardial HDAC3 is required for myocardial trabeculation

Nature Communications, 2023
Abstract Failure of proper ventricular trabeculation is often associated with congenital heart disease. Support from endocardial cells, including the secretion of extracellular matrix and growth factors is critical for trabeculation.
Jihyun Jang, Mette Bentsen, Ye Jun Kim, Erick Kim, Vidu Garg, Chen-Leng Cai, Mario Looso, Deqiang Li   +7 more
openaire   +5 more sources

Characterization of a human RPD3 ortholog, HDAC3 [PDF]

Proceedings of the National Academy of Sciences, 1998
Histone acetylation levels in cells result from a dynamic equilibrium between competing histone acetylases and deacetylases. Changes in histone acetylation levels occur during both transcriptional activation and silencing. Cloning of the cDNA for a human histone deacetylase (HDAC1) has shown that it represents a human ortholog of ...
Emiliani, Serena, Fischle, W, Van Lint, Carine, Al-Abed, Y, Verdin, Eric   +4 more
openaire   +4 more sources

Cardiac HDAC3 Disruption Contributes to HDAC Inhibitor-Induced QT Prolongation. [PDF]

Cells
Histone deacetylase (HDAC) inhibitors are approved for cancer treatment and are being investigated for a wide range of other diseases. Despite their therapeutic promise, clinical studies have reported cardiac side effects, particularly electrocardiogram (
Lu J, Ward C, Qian S, Zhang L, Chang J, Sun Z.   +5 more
europepmc   +2 more sources

Hdac3 suppresses apoptosis through deacetylating and stabilizing the antiapoptotic protein Diap1. [PDF]

Sci Adv
Apoptosis is a highly conserved process that eliminates unwanted or damaged cells in both physiological and pathological conditions.
Zhou D, Liu B, Ding Y, Wang Y, Sun Y, Xu S, Li H, Wang X, Zhao Y, Liu Q, Zhou Z.   +10 more
europepmc   +2 more sources

HDAC3 promotes macrophage pyroptosis via regulating histone deacetylation in acute lung injury

iScience, 2023
Summary: Activated inflammation and pyroptosis in macrophage are closely associated with acute lung injury (ALI). Histone deacetylase 3 (HDAC3) serves as an important enzyme that could repress gene expression by mediating chromatin remodeling.
Ning Li, Bohao Liu, Ruyuan He, Guorui Li, Rui Xiong, Tinglv Fu, Donghang Li, Chenzhen Xu, Bo Wang, Qing Geng   +9 more
doaj   +1 more source

Toxicity of overexpressed MeCP2 is independent of HDAC3 activity [PDF]

Genes & Development, 2018
Duplication of the X-linked MECP2 gene causes a severe neurological syndrome whose molecular basis is poorly understood. To determine the contribution of known functional domains to overexpression toxicity, we engineered a mouse model that expresses wild-type or mutated MeCP2 from the Mapt (Tau) locus in addition to the endogenous protein. Animals that
Koerner, Martha V., Fitzpatrick, Laura, Selfridge, Jim, Guy, Jacky, De Sousa, Dina, Tillotson, Rebekah, Kerr, Alastair, Sun, Zheng, Lazar, Mitchell A., Lyst, Matthew J., Bird, Adrian; id_orcid 0000-0002-8600-0372   +10 more
openaire   +5 more sources

Downregulated HDAC3 or up-regulated microRNA-296-5p alleviates diabetic retinopathy in a mouse model

Regenerative Therapy, 2022
Objective: It has been demonstrated the efficacy of histone deacetylase 3 (HDAC3) in diabetes. Nevertheless, the function of HDAC3 in diabetic retinopathy (DR) remained largely obscure.
Songtian Che, Shuai Wu, Peng Yu
doaj   +1 more source