Results 21 to 30 of about 3,215 (191)

HDAC3 at the Fulcrum of an Epithelial-Mesenchymal Balance [PDF]

Molecular Cell, 2011
In this issue of Molecular Cell, Wu et al. (2011) reveal an essential role for a chromatin modifier, histone deacetylase 3 (HDAC3), in hypoxia-induced epithelial-mesenchymal transition (EMT); HIF-activated HDAC3 integrates with WDR5 to impose chromatin modifications that culminate in EMT.
Mani, Sendurai A., Barton, Michelle Craig   +1 more
openaire   +2 more sources

Endocardial HDAC3 is required for myocardial trabeculation

Nature Communications, 2023
Abstract Failure of proper ventricular trabeculation is often associated with congenital heart disease. Support from endocardial cells, including the secretion of extracellular matrix and growth factors is critical for trabeculation.
Jihyun Jang, Mette Bentsen, Ye Jun Kim, Erick Kim, Vidu Garg, Chen-Leng Cai, Mario Looso, Deqiang Li   +7 more
openaire   +5 more sources

Characterization of a human RPD3 ortholog, HDAC3 [PDF]

Proceedings of the National Academy of Sciences, 1998
Histone acetylation levels in cells result from a dynamic equilibrium between competing histone acetylases and deacetylases. Changes in histone acetylation levels occur during both transcriptional activation and silencing. Cloning of the cDNA for a human histone deacetylase (HDAC1) has shown that it represents a human ortholog of ...
Emiliani, Serena, Fischle, W, Van Lint, Carine, Al-Abed, Y, Verdin, Eric   +4 more
openaire   +4 more sources

Differential effect of HDAC3 on cytoplasmic and nuclear huntingtin aggregates.

PLoS ONE, 2014
Histone deacetylases (HDACs) are potential therapeutic targets of polyglutamine (pQ) diseases including Huntington's disease (HD) that may function to correct aberrant transcriptional deactivation caused by mutant pQ proteins.
Tatsuo Mano, Takayoshi Suzuki, Shoji Tsuji, Atsushi Iwata   +3 more
doaj   +1 more source

Coordinated silencing of the Sp1-mediated long noncoding RNA MEG3 by EZH2 and HDAC3 as a prognostic factor in pancreatic ductal adenocarcinoma

Cancer Biology & Medicine, 2020
Objective: Pancreatic ductal adenocarcinoma (PDAC) is a disease with high mortality. Many so-called “junk” noncoding RNAs need to be discovered in PDAC.
Ting Han, Meng Zhuo, Cuncun Yuan, Xiuying Xiao, Jiujie Cui, Guangrong Qin, Liwei Wang, Feng Jiao   +7 more
doaj   +1 more source

Toxicity of overexpressed MeCP2 is independent of HDAC3 activity [PDF]

Genes & Development, 2018
Duplication of the X-linked MECP2 gene causes a severe neurological syndrome whose molecular basis is poorly understood. To determine the contribution of known functional domains to overexpression toxicity, we engineered a mouse model that expresses wild-type or mutated MeCP2 from the Mapt (Tau) locus in addition to the endogenous protein. Animals that
Koerner, Martha V., Fitzpatrick, Laura, Selfridge, Jim, Guy, Jacky, De Sousa, Dina, Tillotson, Rebekah, Kerr, Alastair, Sun, Zheng, Lazar, Mitchell A., Lyst, Matthew J., Bird, Adrian; id_orcid 0000-0002-8600-0372   +10 more
openaire   +5 more sources

HDAC3 is essential for DNA replication in hematopoietic progenitor cells [PDF]

, 2013
Histone deacetylase 3 (HDAC3) contributes to the regulation of gene expression, chromatin structure, and genomic stability. Because HDAC3 associates with oncoproteins that drive leukemia and lymphoma, we engineered a conditional deletion allele in mice ...
Christina E. Wells, Summers, Alyssa R, Fischer, Melissa A, Chen, Xi, Jonathan F. Kaiser, Srividya Bhaskara, Shilpa Sampathi, Hunt, Aubrey, Jessica W. Luzwick, Mary Ann Thompson, Scott W. Hiebert, Yue Zhao, Zhao, Yue, Kristy R. Stengel, Xi Chen, David Cortez, Wells, Christina E, Stengel, Kristy R, Kaiser, Jonathan F, Melissa A. Fischer, Luzwick, Jessica W, Sampathi, Shilpa, Hiebert, Scott W, Aubrey Hunt, Alyssa R. Summers, Cortez, David, Bhaskara, Srividya, Thompson, Mary Ann   +27 more
core   +1 more source

Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Histone deacetylase 3 (HDAC3) can acetylate histones, negatively regulating Neuronal Per-Arnt-Sim domain protein 4 (Npas4) and participating in various pathological processes of central nervous system lesions.
Haiping Gu, Yating Gong, Muyao Wu, Mengying Shi, Jiejie Yu, Hongfei Zhu, Ya-ming Sun, Baoqi Dang   +7 more
doaj   +1 more source

Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury

Journal of Neuroinflammation, 2022
Background Histone deacetylases (HDACs) are believed to exacerbate traumatic brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform responsible for the detrimental effects and the cell types involved remain unknown ...
Yongfang Zhao, Hongfeng Mu, Yichen Huang, Sicheng Li, Yangfan Wang, R. Anne Stetler, Michael V. L. Bennett, C. Edward Dixon, Jun Chen, Yejie Shi   +9 more
doaj   +1 more source

Downregulated HDAC3 or up-regulated microRNA-296-5p alleviates diabetic retinopathy in a mouse model

Regenerative Therapy, 2022
Objective: It has been demonstrated the efficacy of histone deacetylase 3 (HDAC3) in diabetes. Nevertheless, the function of HDAC3 in diabetic retinopathy (DR) remained largely obscure.
Songtian Che, Shuai Wu, Peng Yu
doaj   +1 more source