Results 21 to 30 of about 18,122 (224)

Microglial HDAC3 inhibits the migration of CD8-positive T cell in the development of EAE by restraining the expression of CCL5 [PDF]

Cell & Bioscience
Background Multiple sclerosis (MS) is a central nervous system disease caused by auto-immune reaction induced demyelination, however, the molecular mechanism of MS remains unclear. Previous study revealed that histone deacetylase 3 (HDAC3) is upregulated
Na Che, Yang Zhang, Bo Wang, Hongxing Wu, Zhiqiong Mao, Zengqiang Yuan, Xiangxi Kong, Yajin Liao   +7 more
doaj   +2 more sources

HDAC3 and HDAC8 are required for cilia assembly and elongation

Biology Open, 2019
Cilia are extended from mother centrioles in quiescent G0/G1 cells and retracted in dividing cells. Diverse post-translational modifications play roles in the assembly and disassembly of the cilium.
Park, Seon-ah, Yoo, Hyunjeong, Rhee, Kunsoo, Seol, Jae Hong   +3 more
core   +4 more sources

HDAC3 Preserves the primordial follicle reserve by epigenetically suppressing ferroptosis in pregranulosa cells [PDF]

Cellular and Molecular Life Sciences
The non-renewable primordial follicle (PF) pool underlies female reproductive longevity, yet PF numbers decline sharply before puberty for reasons that remain unclear.
Ziqi Chen, Jiantao Guo, Meng Gao, Huarong Wang, Han Cai, Qingfeng Yang, Xinyu Yang, Yi Lin, Zijian Zhu, Shaogang Qin, Yibing Bao, Ting Zhao, Longping Liu, Tengteng Wang, Bo Zhou, Hua Zhang, Jianbin Wang, Hua Guo, Guoliang Xia, Chao Wang   +19 more
doaj   +2 more sources

Phytic acid (InsP6) activates HDAC3 epigenetic axis to maintain intestinal barrier function [PDF]

Nature Communications
HDAC inhibition shows promise in cancer treatment but pan-HDAC inhibitors cause gastrointestinal issues in 48% of patients. Understanding HDAC activation mechanisms is crucial to treating diverse diseases beyond cancer.
Sujan Chatterjee, Zachary Sin, Nguyen Tran, Loretta Vierra, Anuj Shukla, Tam Tran, George Koshkaryan, Kevin Ritter, Xue Bessie Su, Saharat Jolak Ragsac, Seungman Park, Qian Liu, Richard Van, Katherine Huang, Kayci Huff-Hardy, Richard Rood, Anas Gremida, Martin Gregory, Chien-Huan Chen, Mira V. Han, Parakkal Deepak, Adolfo Saiardi, Henning J. Jessen, Prasun Guha   +23 more
doaj   +2 more sources

Designing potential HDAC3 inhibitors to improve memory and learning

Journal of Biomolecular Structure and Dynamics, 2019
The work presented here explores the structural and physicochemical features important for benzamide-based HDAC3 inhibitors to get an idea about the design aspect of potential inhibitors.
Nilanjan Adhikari (3825796), Sk. Abdul Amin (3825802), Tarun Jha (632366), Balaram Ghosh (129360)   +3 more
core   +3 more sources

Inositol hexaphosphate promotes intestinal adaptation in short bowel syndrome via an HDAC3-mediated epigenetic pathway

Food & Nutrition Research, 2023
Background: Short bowel syndrome (SBS) has high morbidity and mortality rates, and promoting intestinal adaptation of the residual intestine is a critical treatment.
Weipeng Wang, Ying Wang, Ying Lu, Xinbei Tian, Shanshan Chen, Bo Wu, Jun Du, Yongtao Xiao, Wei Cai   +8 more
doaj   +1 more source

Histone deacetylase 3 regulates microglial function through histone deacetylation

Epigenetics, 2023
As the primary innate immune cells of the brain, microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules.
Laura Meleady, Morgan Towriss, Jennifer Kim, Vince Bacarac, Vivien Dang, Megan E. Rowland, Annie Vogel Ciernia   +6 more
doaj   +1 more source

Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Clinical Epigenetics, 2023
Background Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates protein stability by modulating the ...
Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu, Zhaoyu Hu, Bo Hao, Ning Li, Qing Geng   +7 more
doaj   +1 more source

HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control

Redox Biology, 2023
Sepsis is one common cause of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which is closely associated with high mortality in intensive care units (ICU). Histone deacetylase 3 (HDAC3) serves as an important epigenetic modifying
Ning Li, Bohao Liu, Rui Xiong, Guorui Li, Bo Wang, Qing Geng   +5 more
doaj   +1 more source

Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2

BMC Cancer, 2023
Background Hepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens and higher circumstantial levels of interleukin-6 (IL-6) produced by resident hepatic macrophages. Methods
Yahong Xu, Yongjie Zhu, Zhenru Wu, Shengfu Li, Mingyang Shao, Qing Tao, Qing Xu, Yuwei Chen, Yuke Shu, Menglin Chen, Yongjie Zhou, Yujun Shi   +11 more
doaj   +1 more source