Results 21 to 30 of about 24,258 (228)

Differential effect of HDAC3 on cytoplasmic and nuclear huntingtin aggregates.

PLoS ONE, 2014
Histone deacetylases (HDACs) are potential therapeutic targets of polyglutamine (pQ) diseases including Huntington's disease (HD) that may function to correct aberrant transcriptional deactivation caused by mutant pQ proteins.
Tatsuo Mano, Takayoshi Suzuki, Shoji Tsuji, Atsushi Iwata   +3 more
doaj   +1 more source

The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo [PDF]

, 2008
Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical ...
Atmaca, Ausra Mickuckyte, Bacon, Beecken, Biffi, Blaheta, Blaheta, Cinatl, Cinatl, Dietger Jonas, Eva Juengel, Gao, Greenblatt, Hedberg, Hedberg, Jacobsohn, Jon Jones, Kaneko, Kuefer, Kuljaca, Langner, Levidou, Lucero Gritti, Lukasz Hudak, Michaelis, Motzer, Munster, Okamoto, Olshavsky, Pertia, Qian, Rojas, Roman A. Blaheta, Rubagotti, Shabbeer, Steffen Wedel, Tan, Tsutsumida, Valentini, Wolfrom, Xia, Yamamoto-Yamaguchi, Yang   +42 more
core   +1 more source

Dissecting HDAC3-mediated tumor progression [PDF]

Cancer Biology & Therapy, 2008
Commentary to:HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signalingCassandra A. Godman, Rashmi Joshi, Brendan R. Tierney, Emily Greenspan, Theodore P. Rasmussen, Hsin-wei Wang, Dong-Guk Shin, Daniel W.
openaire   +2 more sources

EGFR–c-Src-Mediated HDAC3 Phosphorylation Exacerbates Invasion of Breast Cancer Cells

Cells, 2019
Breast cancer is one of the leading causes of morbidity and mortality among women. Epidermal growth factor receptor (EGFR) and proto-oncogene tyrosine-protein kinase Src (c-Src) are critical components of the signaling pathways that are associated with ...
Sung-Min Kwak, Jaesung Seo, Jin-Taek Hwang, Gi-Jun Sung, Ji-Hye Song, Ji-Hoon Jeong, Seung-Hyun Lee, Ho-Geun Yoon, Hyo-Kyoung Choi, Kyung-Chul Choi   +9 more
doaj   +1 more source

Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease

Translational Neuroscience, 2020
Amyloid-beta (Aβ) plaque deposits and neurofibrillary tangles containing tau proteins are the key pathognomonic manifestations of Alzheimer’s disease (AD). Lack of holistic drugs for AD has reinvigorated enthusiasm in the natural product-based therapies.
Li Zhengyu, Gan Li, Yan Si, Yan Yufang, Huang Wei   +4 more
doaj   +1 more source

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer [PDF]

, 2016
Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer ...
A Hayashi, A Mai, A Saito, A Vannini, A Villar-Garea, AA Lane, AJ Dembo, AJ Wilson, Albandri Alfraidi, AM Abukhdeir, Aun Muhammad, AW Kurian, B Sorbe, BA Goff, BD Strahl, BH Huang, BY Karlan, C Aghajanian, C Bosetti, C Campas-Moya, C Gomez-Raposo, CJ Dunton, CM Grozinger, CS Marcus, CT Lin, D Khabele, D Matei, D Mottet, D Strumberg, D Waltregny, DC Drummond, DD Bowtell, DE Marsden, DK Armstrong, DM Dinulescu, Dmitri Pchejetski, DO Bauerschlag, E Hu, E Smolle, E Verdin, G Piperno, G Tortolero-Luna, H Naora, HA Risch, Heba Alshaker, HL Cheng, I Cetin, IK Kolasa, J Boyd, J Morrison, J Permuth-Wey, J Plisiecka-Halasa, J Prat, J Sonnemann, J Zhang, JA Rauh-Hain, JE Bolden, JE Palmer, JF Stratton, JH Choi, JJ Hwang, JL Benedet, JL MacDonald, JL Walker, JM Piek, JP Secrist, JR Graff, JR Ribeiro, K Kudoh, K Ozaki, K Sawada, K Struhl, KA Lowe, KB Glaser, Keith Sacco, KF McGonigle, KR Cho, L Dai, Leonardo Monzon, M Booth, M Fung-Kee-Fung, M Kartalou, M Markman, M Ohmichi, M Schuijer, MF Fathalla, MJ Piccart, MJ Scanlan, MK Tuxen, ML Friedlander, MM Leitao, MS Finnin, MS Kim, N Einhorn, N Einhorn, N Takai, N Takai, N Takai, NC Hait, NG Gavalas, NS Bese, P Marks, P Zhu, PH Wang, R Furumai, RA Burger, RA Burger, RC Bast Jr, RF Ozols, RL Coleman, RP Warrell Jr, RP Wernyj, S Gregoire, S Rinaldi, S Senese, S Spiegel, SA Cannistra, SA Gayther, SA Gayther, SC Modesitt, SR Wedge, T Meyer, TJ Herzog, TJ Perren, TL Klug, V Auner, V Conteduca, W Fischle, W Weichert, X Qian, YV Shebzukhov   +130 more
core   +1 more source

The Nuclear Envelope Protein Emerin Binds Directly to Histone Deacetylase 3 (HDAC3) and Activates HDAC3 Activity [PDF]

Journal of Biological Chemistry, 2012
Organization of the genome is critical for maintaining cell-specific gene expression, ensuring proper cell function. It is well established that the nuclear lamina preferentially associates with repressed chromatin. However, the molecular mechanisms underlying repressive chromatin formation and maintenance at the nuclear lamina remain poorly understood.
Justin, Demmerle, Adam J, Koch, James M, Holaska   +2 more
openaire   +2 more sources

Downregulated HDAC3 or up-regulated microRNA-296-5p alleviates diabetic retinopathy in a mouse model

Regenerative Therapy, 2022
Objective: It has been demonstrated the efficacy of histone deacetylase 3 (HDAC3) in diabetes. Nevertheless, the function of HDAC3 in diabetic retinopathy (DR) remained largely obscure.
Songtian Che, Shuai Wu, Peng Yu
doaj   +1 more source

Transducin beta-like gene FTL1 is essential for pathogenesis in Fusarium graminearum [PDF]

, 2009
Fusarium head blight caused by Fusarium graminearum is an important disease of wheat and barley. In a previous study, we identified several mutants with reduced virulence by insertional mutagenesis. A transducin beta-like gene named FTL1 was disrupted in
Ding, S.L., Mehrabi, R., Koten, C., Kang, Z.S., Wei, Y.D., Seong, K., Corby Kistler, H., Xu, J.R.   +7 more
core   +2 more sources

HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis [PDF]

Journal of Dental Research, 2019
Histone deacetylases (HDACs) are important regulators of gene expression that are aberrantly regulated in several inflammatory and infectious diseases. HDAC inhibitors (HDACi) suppress inflammatory activation of various cell types through epigenetic and non-epigenetic mechanisms, and ameliorate pathology in a mouse model of periodontitis.
K.B. Lagosz, A. Bysiek, J.M. Macina, G.P. Bereta, M. Kantorowicz, W. Lipska, M. Sochalska, K. Gawron, T. Kaczmarzyk, M. Chomyszyn-Gajewska, G. Fossati, J. Potempa, A.M. Grabiec   +12 more
openaire   +3 more sources