Results 111 to 120 of about 137,192 (357)

Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition

Molecules, 2018
We designed and synthesized carbamates of the clinically-approved HDAC (histone deacetylase) inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) in order to validate our previously-proposed hypothesis that these carbamates might serve as ...
Kristina King, Alexander-Thomas Hauser, Jelena Melesina, Wolfgang Sippl, Manfred Jung   +4 more
doaj   +1 more source

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Supplementary Fig. S1 from Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model [PDF]

, 2023
Akihiko Miyanaga, Akihiko Gemma, Rintaro Noro, Kiyoko Kataoka, Kuniko Matsuda, Michiya Nara, Tetsuya Okano, Masahiro Seike, Akinobu Yoshimura, Akiko Kawakami, Haruka Uesaka, Hiroki Nakae, Shoji Kudoh   +12 more
openalex   +1 more source

Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression [PDF]

, 2010
Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, emphysema and irreversible airflow limitation. These changes are thought to be due to oxidative stress and an imbalance of proteases and antiproteases ...
A Babusyte, A Kode, A Papi, A Sebastian, A Sydbom, AP Rogerio, AW Boots, C Kandaswami, C Tabak, CJ Vlahos, D Nowak, DC Newcomb, EH Walker, G Agullo, GA Finlay, GW Peet, HJ Park, HS Deshmukh, HS Deshmukh, I Rahman, IC Walda, IK Demedts, J Robak, JA Conquer, JC Chen, JD Hasday, JH Vernooy, JW Hwang, K Ito, K Minamoto, K Ohnishi, KF Chung, KK Meja, L Biasutto, L Larsson, L Segura-Valdez, M Comalada, M Harwood, M Ichinose, M Kasielski, M Suzuki, MK Hwang, MM Mu, N Louhelainen, O Michel, P Maestrelli, P Santus, PC Hollman, PF Mercer, PJ Jagielo, R Mahadeva, S Nanua, S Rajendrasozhan, S Shishodia, SK Biswas, SP Davies, SV Culpitt, T Shinohara, T Zheng, U Sajjan, W MacNee, Y Kaneko, Y Nakamaru, Y-T Huang   +63 more
core   +6 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]

, 2018
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang, Lau, Bonnie, Lau, Wayne Bond, Tang, Kexin, Wang, Hongjing, Wang, Wei, Wang, Xin, Wei, Yuquan, Xu, Lian, Yang, Qilian, Yang, Yuqing, Yang, Zhengnan, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Nianxin, Zhou, Shengtao   +16 more
core   +2 more sources

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. [PDF]

, 2019
Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA polymerase II (Pol II) pauses before proceeding toward productive elongation.
Ablondi, Eileen, Adelman, Karen, Chang, Andrew, Choi, Jee-Eun, Etchegaray, Jean-Pierre, Ferrer, Christina, Goren, Alon, Henriques, Telmo, Ji, Fei, Li, Catherine, Mostoslavsky, Raul, Nakadai, Tomoyoshi, Nechaev, Sergei, Ramaswamy, Sridhar, Roeder, Robert G, Ross, Kenneth N, Sadreyev, Ruslan I, Samarakkody, Ann, Van Rechem, Capucine, Whetstine, Johnathan R, Zhong, Lei   +20 more
core   +1 more source

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]

, 2008
The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
Atmaca, Akin, Batran, Salah-Eddin al-, Blaheta, Roman A., Hudak, Lukasz, Jonas, Dietger, Jüngel, Eva, Soldato, Piero Del, Sparatore, Anna, Wedel, Steffen Alexander   +8 more
core   +1 more source