Results 91 to 100 of about 208,828 (307)

Snail regulation in fibroblast-like synoviocytes by a histone deacetylase or glycogen synthase kinase inhibitor affects cell proliferation and gene expression.

PLoS ONE, 2021
BackgroundSnail has been linked to the pathogenesis of rheumatoid arthritis (RA). We plan to investigate the regulation of Snail in response to TNF-α, histone acetylation, and glycogen synthase kinase-3 (GSK)-3 inhibition in fibroblast-like synoviocytes (
Po-Chuan Shen, Po-Chun Chang, Jeng-Long Hsieh   +2 more
doaj   +1 more source

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. [PDF]

, 2019
Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA polymerase II (Pol II) pauses before proceeding toward productive elongation.
Ablondi, Eileen, Adelman, Karen, Chang, Andrew, Choi, Jee-Eun, Etchegaray, Jean-Pierre, Ferrer, Christina, Goren, Alon, Henriques, Telmo, Ji, Fei, Li, Catherine, Mostoslavsky, Raul, Nakadai, Tomoyoshi, Nechaev, Sergei, Ramaswamy, Sridhar, Roeder, Robert G, Ross, Kenneth N, Sadreyev, Ruslan I, Samarakkody, Ann, Van Rechem, Capucine, Whetstine, Johnathan R, Zhong, Lei   +20 more
core   +1 more source

Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]

, 2017
Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana, Cippitelli, Marco, Fionda, Cinzia, Santoni, Angela, Soriani, Alessandra, Zingoni, Alessandra   +5 more
core   +1 more source

Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostat

Breast Cancer Research, 2012
Of the more than one million global cases of breast cancer diagnosed each year, approximately fifteen percent are characterized as triple-negative, lacking the estrogen, progesterone, and Her2/neu receptors.
C. Tate, L. Rhodes, Chris Segar, Jennifer L. Driver, N. Pounder, M. Burow, B. Collins-Burow   +6 more
semanticscholar   +1 more source

Supplementary Figure 2 from Histone Deacetylase Inhibitors Induce Cell Death Selectively in Cells That Harbor Activated kRasV12: The Role of Signal Transducers and Activators of Transcription 1 and p21 [PDF]

, 2023
Lidija Klampfer, Jie Huang, Senji Shirasawa, Takehiko Sasazuki, Leonard H. Augenlicht   +4 more
openalex   +1 more source

Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. [PDF]

PLoS ONE, 2009
Enzyme-catalyzed, post-translational modifications of core histones have been implicated in the complex changes in gene expression that drive early mammalian development.
Matthew D VerMilyea, Laura P O'Neill, Bryan M Turner   +2 more
doaj   +1 more source

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells [PDF]

, 2016
Cancer stem cells (CSCs) play an important role in tumor initiation, progression, therapeutic failure and tumor relapse. In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl ...
Buglioni, Simonetta, Carradori, Simone, DE LUCA, Teresa, De Maria, Ruggero, Del Bufalo, Donatella, Desideri, Marianna, DI MARTILE, Marta, Eramo, Adriana, Gabellini, Chiara, Mai, Antonello, Milella, MICHELE STANISLAW, Rotili, Dante, Secci, Daniela, Sette, Giovanni, Trisciuoglio, Daniela   +14 more
core   +4 more sources

Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP

Translational Oncology, 2016
Background: The current chemotherapeutic outcomes for hepatocellular carcinoma (HCC) are not encouraging, and long-term survival of this patient group remains poor.
Jing Liu, Guangming Li, Xiang Wang, Liang Wang, Rui Zhao, Juanxia Wang, Yin Kong, Jie Ding, Juan Li, Lingyi Zhang   +9 more
doaj   +1 more source

Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity [PDF]

, 2016
Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been
Andrade, Ricardo, Arluzea, Jon, Aréchaga, Juan, De Wever, Olivier, Díaz-Núñez, María, Díez-Torre, Alejandro, Silió, Margarita   +6 more
core   +4 more sources

Supplementary Fig. S1 from Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model [PDF]

, 2023
Akihiko Miyanaga, Akihiko Gemma, Rintaro Noro, Kiyoko Kataoka, Kuniko Matsuda, Michiya Nara, Tetsuya Okano, Masahiro Seike, Akinobu Yoshimura, Akiko Kawakami, Haruka Uesaka, Hiroki Nakae, Shoji Kudoh   +12 more
openalex   +1 more source