Results 81 to 90 of about 208,828 (307)

Inhibiting Histone Deacetylase 2 (HDAC2) Promotes Functional Recovery From Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundStroke is a leading cause of long‐term disability worldwide. However, current therapies that promote functional recovery from stroke are limited to physical rehabilitation. No pharmacological therapy is available.
Ying Tang, Yu‐Hui Lin, Huan‐Yu Ni, Jian Dong, Hong‐Jin Yuan, Yu Zhang, Hai‐Ying Liang, Meng‐Cheng Yao, Qi‐Gang Zhou, Hai‐Yin Wu, Lei Chang, Chun‐Xia Luo, Dong‐Ya Zhu   +12 more
doaj   +1 more source

New insights into the epigenetic control of satellite cells [PDF]

, 2015
Epigenetics finely tunes gene expression at a functional level without modifying the DNA sequence, thereby contributing to the complexity of genomic regulation.
Adamo, Sergio, Marroncelli, Nicoletta, Moresi, Viviana   +2 more
core   +1 more source

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor [PDF]

, 2023
Canrong Li, Yingyi Ouyang, Chuxin Lu, Feng-Zhi Chen, Yuguo Yi, Shujun Peng, Yifan Wang, Xinyu Chen, Xiao Yan, Shuiming Li, Lin Feng, Xiaoduo Xie   +11 more
openalex   +1 more source

Enhanced autophagic clearance of amyloid-β via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer’s disease in vitro and in vivo

Neural Regeneration Research
Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-β in neurons, which is a key step in senile plaque formation.
Zhimin Long, Chuanhua Ge, Yueyang Zhao, Yuanjie Liu, Qinghua Zeng, Qing Tang, Zhifang Dong, Guiqiong He   +7 more
doaj   +1 more source

Histone Deacetylase Inhibitors: Synthesis of Tetrapeptide Analogue SAHA/TPX

E-Journal of Chemistry, 2011
The inhibition of HDAC (histone deacetylase) activity by specific inhibitors induces growth arrest, differentiation and apoptosis of transformed or several cancer cells. Some of these inhibitors are in clinical trial at phase I or phase II. The discovery
Lynda Ekou, Tchirioua Ekou, Isabelle Opalinski, Jean Pierre Gesson   +3 more
doaj   +1 more source

Syntheses and Biological Activity of the HDAC Class I Inhibitor Largazole

CHIMIA, 2009
Histone deacetylase inhibitors are an emerging class of antiproliferative agents that have the potential to combat cancer on an epigenetic level.
Tobias Seiser, Nicolai Cramer
doaj   +1 more source

HDAC inhibition potentiates immunotherapy in triple negative breast cancer. [PDF]

, 2017
Triple-negative breast cancer (TNBC) represents a more aggressive and difficult subtype of breast cancer where responses to chemotherapy occur, but toxicity is significant and resistance often follows. Immunotherapy has shown promising results in various
Ali, Niwa, Budillon, Alfredo, Krings, Gregor, Munster, Pamela N, Park, Jeenah, Pawlowska, Nela, Rosenblum, Michael D, Terranova-Barberio, Manuela, Thomas, Scott   +8 more
core   +1 more source

Tumour-targeted interleukin-12 and entinostat combination therapy improves cancer survival by reprogramming the tumour immune cell landscape

Nature Communications, 2021
The immunocytokine NHS-IL12 is targeted to necrotic tumour areas to prompt an immune response. Authors show here in mouse colon and breast models that the combination of histone deacetylase inhibitor, Entinostat, and NHS-IL12 generates a tumour ...
Kristin C. Hicks, Paul L. Chariou, Yohei Ozawa, Christine M. Minnar, Karin M. Knudson, Thomas J. Meyer, Jing Bian, Margaret Cam, Jeffrey Schlom, Sofia R. Gameiro   +9 more
doaj   +1 more source

The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo [PDF]

, 2008
Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical ...
Atmaca, Ausra Mickuckyte, Bacon, Beecken, Biffi, Blaheta, Blaheta, Cinatl, Cinatl, Dietger Jonas, Eva Juengel, Gao, Greenblatt, Hedberg, Hedberg, Jacobsohn, Jon Jones, Kaneko, Kuefer, Kuljaca, Langner, Levidou, Lucero Gritti, Lukasz Hudak, Michaelis, Motzer, Munster, Okamoto, Olshavsky, Pertia, Qian, Rojas, Roman A. Blaheta, Rubagotti, Shabbeer, Steffen Wedel, Tan, Tsutsumida, Valentini, Wolfrom, Xia, Yamamoto-Yamaguchi, Yang   +42 more
core   +1 more source

Histone Deacetylases and Their Inhibitors in Cancer Epigenetics [PDF]

Diseases, 2019
Histone deacetylases (HDAC) and histone deacetylase inhibitors (HDACi) have greatly impacted the war on cancer. Their role in epigenetics has significantly altered the development of anticancer drugs used to treat the most rare, persistent forms of cancer.
openaire   +3 more sources