Results 221 to 230 of about 137,192 (357)

Histone deacetylases and inhibitors in diabetes mellitus and its complications

Wang Li, Yuning Bai, Zhengmin Cao, Ziwei Guo, Yanjie Lian, Pan Liu, Yixian Zeng, Wenliang Lyu, Qiu Chen   +8 more
openalex   +1 more source

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, EarlyView.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

Exploring the potential of Gonolobus condurango as a histone deacetylase inhibitor in triple-negative breast cancer cell lines: in vitro study. [PDF]

BMC Complement Med Ther
Vajen B, Schäffer V, Eilers M, Schlegelberger B, Skawran B.   +4 more
europepmc   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Corrigendum to "Antitumor Action of a Novel Histone Deacetylase Inhibitor, YF479, in Breast Cancer" [Neoplasia. 2014 Aug;16(8):665-77]. [PDF]

Neoplasia
Zhang T, Chen Y, Li J, Yang F, Wu H, Dai F, Hu M, Lu X, Peng Y, Liu M, Zhao Y, Yi Z.   +11 more
europepmc   +1 more source

Histone Deacetylase Inhibitor (SAHA) Reduces Mortality in an Endotoxemia Mouse Model by Suppressing Glycolysis. [PDF]

Int J Mol Sci, 2023
Wu Y, He Y, Liu C, Ehle C, Iyer-Bierhoff A, Liu B, Heinzel T, Xing S.   +7 more
europepmc   +1 more source

Histone Deacetylase (HDAC) Inhibitors with a Novel Connecting Unit Linker Region Reveal a Selectivity Profile for HDAC4 and HDAC5 with Improved Activity against Chemoresistant Cancer Cells

, 2012
Linda Marek, Alexandra Hamacher, Finn K. Hansen, Krystina Kuna, Holger Gohlke, Matthias U. Kassack, Thomas Kurz   +6 more
openalex   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Brain-penetrant histone deacetylase inhibitor RG2833 improves spatial memory in females of an Alzheimer's disease rat model. [PDF]

J Alzheimers Dis
Ndukwe K, Serrano PA, Rockwell P, Xie L, Figueiredo-Pereira ME.   +4 more
europepmc   +1 more source

Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells

, 2006
Xudong Ma, Yuqiang Fang, A. Beklemisheva, Wei Dai, Fenghua Wang, Tauseef Ahmed, Delong Liu, Jen Wei Chiao   +7 more
openalex   +2 more sources